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Bruce A. Kowalczyk

Hoffmann-La Roche

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Featured researches published by Bruce A. Kowalczyk.

Synthetic Communications | 1996

IMPROVED PREPARATION OF (R) AND (S)-3-AMINOQUINUCLIDINE DIHYDROCHLORIDE

Bruce A. Kowalczyk; John C. Rohloff; Charles Alois Dvorak; John O. Gardner

Abstract An improved procedure for the synthesis of either (R) or (S)-3-aminoquinuclidine was developed. Key intermediate imine 2 was made in a one pot process using lithium oxide as the base and molecular sieves.

Journal of Organic Chemistry | 1998

Synthesis of the Spatane Nucleus (cis-anti-cis-tricyclo[5.3.0.02,6]decane) using the Pauson−Khand Reaction with a Remarkable Reversal in Regioselectivity

Bruce A. Kowalczyk; Timothy C. Smith; William G. Dauben

Archive | 2003

2-(substituted-phenyl)amino-imidazoline derivatives

Keith R. Bley; Robin D. Clark; Alam Jahangir; Bruce A. Kowalczyk; Francisco Javier Lopez-Tapia; Alexander Victor Muehldorf; Counde O'yang; Thomas Weitao Sun

Archive | 1994

Process for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one

James M. A. Robinson; John C. Rohloff; Bruce A. Kowalczyk

Archive | 1998

2-(Arylphenyl)amino-imidazoline derivatives

Keith R. Bley; Robin Douglas Clark; Alam Jahangir; Bruce A. Kowalczyk; Francisco Javier Lopez-Tapala; Alexander Victor Muehldorf; Counde O'yang; Thomas Weitao Sun

Archive | 1994

Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein

Bruce A. Kowalczyk; Charles Alois Dvorak

Synthesis | 1997

SYNTHESIS OF DIHALOPHENYLACETIC ACIDS USING AROMATIC NUCLEOPHILIC SUBSTITUTION STRATEGY

Bruce A. Kowalczyk

Synthesis | 2000

Total Synthesis of RS-42358 and Analogs Using Lateral Lithiation

Bruce A. Kowalczyk

Archive | 1995

Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1h-benz(de)isoquinolin-1-one and intermediate product

Charles Alois Dvorak; Bruce A. Kowalczyk

Organic Process Research & Development | 1997

Scale-Up of the Nitration of 1-Acetyl-3,4-dichloro-1,2-(ethylenedioxy)benzene Using Nitric Acid/Trifluoroacetic Acid

Bruce A. Kowalczyk; Philip N. Roberts; and Gerald K. McEwen; James Robinson

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Alam Jahangir

Hoffmann-La Roche

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Alexander Victor Muehldorf

Hoffmann-La Roche

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Charles Alois Dvorak

Hoffmann-La Roche

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Counde O'yang

University of Chicago

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Keith R. Bley

Hoffmann-La Roche

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Thomas Weitao Sun

Hoffmann-La Roche

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John C. Rohloff

University of California

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Francisco Javier Lopez-Tapala

Hoffmann-La Roche

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Francisco Javier Lopez-Tapia

University of Hawaii at Manoa

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John O. Gardner

University at Buffalo

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