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Dive into the research topics where Bruce D. Hilton is active.

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Featured researches published by Bruce D. Hilton.


Polycyclic Aromatic Compounds | 1994

DNA Adducts Formed by syn Dihydrodiol Epoxides of Polycyclic Aromatic Hydrocarbons

Jan Szeliga; Bruce D. Hilton; Hongmee Lee; Ronald G. Harvey; Anthony Dipple

Abstract A brief review of the literature on syn dihydrodiol epoxide DNA adducts is presented. NMR studies indicate that bay region substituents influence the conformation of the partially saturated ring in such adducts. However, only substitutions that lead to distortion from planarity are associated with reactivity towards deoxyadenosine residues in DNA and with greater tumorigenicity. This is similar to the situation that obtains for anti dihydrodiol epoxides.


Chemical Research in Toxicology | 1989

DNA adducts from carcinogenic and noncarcinogenic enantiomers of benzo[a]pyrene dihydrodiol epoxide.

Shee Chau Cheng; Bruce D. Hilton; John M. Roman; Anthony Dipple


Journal of the American Chemical Society | 1987

Chemical characterization of DNA adducts derived from the configurationnally isomeric benzo[c]phenanthrene-3,4-diol 1,2-epoxides

Shiv K. Agarwal; Jane M. Sayer; Herman J. C. Yeh; Lewis K. Pannell; Bruce D. Hilton; Margaret A. Pigott; Anthony Dipple; Haruhiko Yagi; Donald M. Jerina


Carcinogenesis | 1988

A metabolite of the carcinogen 7,12-dimethylbenz[ a ]anthracene that reacts predominantly with adenine residues in DNA

S.C. Cheng; A.S. Prakash; M.A. Pigott; Bruce D. Hilton; Hongmee Lee; Ronald G. Harvey; Anthony Dipple


Chemical Research in Toxicology | 1995

Characterization of DNA adducts formed by anti-benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxide.

Jan Szeliga; John E. Page; Bruce D. Hilton; Alexander S. Kiselyov; Ronald G. Harvey; Yuriy M. Dunayevskiy; Paul Vouros; Anthony Dipple


Chemical Research in Toxicology | 1988

Characterization of 7,12-dimethylbenz[a]anthracene-adenine nucleoside adducts.

Shee Chau Cheng; Prakash As; Pigott Ma; Bruce D. Hilton; John M. Roman; Hongmee Lee; Ronald G. Harvey; Anthony Dipple


Carcinogenesis | 1987

Characterization of 5-methylchrysene-1,2-dihydrodiol-3,4-epoxide—DNA adducts

Dean B. Reardon; A.S. Prakash; Bruce D. Hilton; John M. Roman; John Pataki; Ronald G. Harvey; Anthony Dipple


Chemical Research in Toxicology | 1994

Reaction with DNA and Mutagenic Specificity of syn-Benzo[g]chrysene 11,12-Dihydrodiol 13,14-Epoxide

Jan Szeliga; Hongmee Lee; Ronald G. Harvey; John E. Page; Helen L. Ross; Michael N. Routledge; Bruce D. Hilton; Anthony Dipple


Journal of Organic Chemistry | 1992

Bryostatins revisited: a new bryostatin 3 and the use of NMR to determine stereochemistry in the C-20-C-23 area

Gwendolyn N. Chmurny; Mary P. Koleck; Bruce D. Hilton


Journal of Organic Chemistry | 1991

Effect of bay region methyl group on reactions of anti-benz[a]anthracene 3,4-dihydrodiol 1,2-epoxides with DNA

Kimmo Peltonen; Shee Chau Cheng; Bruce D. Hilton; Hongmee Lee; Cecilia Cortez; Ronald G. Harvey; Anthony Dipple

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Anthony Dipple

National Institutes of Health

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Jan Szeliga

National Institutes of Health

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John E. Page

National Institutes of Health

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Donald M. Jerina

National Institutes of Health

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Haruhiko Yagi

National Institutes of Health

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