Bruce E. Dunn
University of Colorado Denver
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Featured researches published by Bruce E. Dunn.
Microbiology | 1990
Richard T. Ellison; F. M. LaForce; Theodore J. Giehl; Dorothy S. Boose; Bruce E. Dunn
Lactoferrin and transferrin have antimicrobial activity against selected Gram-negative bacteria, but the mechanism of action has not been defined. We studied the ability of lactoferrin and transferrin to damage the Gram-negative outer membrane. Lipopolysaccharide release by the proteins could be blocked by concurrent addition of Ca2+ and Mg2+. Addition of Ca2+ also blocked the ability of lactoferrin to increase the susceptibility of Escherichia coli to rifampicin. Transferrin, but not lactoferrin, increased susceptibility of Gram-negative bacteria to deoxycholate, with reversal of sensitivity occurring with exposure to Ca2+ or Mg2+. In transmission electron microscopy studies polymyxin B caused finger-like membrane projections, but no morphological alterations were seen in cells exposed to EDTA, lactoferrin or transferrin. These data provide further evidence that lactoferrin and transferrin act as membrane-active agents with the effects modulated by Ca2+ and Mg2+.
Infection and Immunity | 1996
Suhas H. Phadnis; Mary H. Parlow; Marilyn A. Levy; Dag Ilver; Casey M. Caulkins; James B. Connors; Bruce E. Dunn
Journal of Biological Chemistry | 1990
Bruce E. Dunn; G P Campbell; Guillermo I. Perez-Perez; Martin J. Blaser
The Journal of Infectious Diseases | 1990
Guillermo I. Perez-Perez; David N. Taylor; Ladaporn Bodhidatta; Jirasak Wongsrichanalai; Wallace B. Baze; Bruce E. Dunn; Peter Echeverria; Martin J. Blaser
Infection and Immunity | 1992
Bruce E. Dunn; R M Roop; C C Sung; S. A. Sharma; Guillermo I. Perez-Perez; M. J. Blaser
Yale Journal of Biology and Medicine | 1998
Bruce E. Dunn; Suhas H. Phadnis
Clinical and Vaccine Immunology | 1994
Guillermo I. Perez-Perez; W R Brown; Timothy L. Cover; Bruce E. Dunn; Ping Cao; M. J. Blaser
Infection and Immunity | 1989
Bruce E. Dunn; Guillermo I. Perez-Perez; Martin J. Blaser
Infection and Immunity | 1987
Bruce E. Dunn; Martin J. Blaser; Edward L. Snyder
Journal of Bacteriology | 1999
Partha Krishnamurthy; Mary H. Parlow; John Schneider; Stephanie Burroughs; Catherine Wickland; Nimish Vakil; Bruce E. Dunn; Suhas H. Phadnis