Bruno de Oliveira Rocha

Psoriasis and uveitis: a literature review

Psoriasis is a systemic, chronic, immunologically mediated disease, with significant genetic and environmental influences. It affects from 1 to 3% of the world population. Recently, the relation between psoriasis and different comorbidities, particularly metabolic syndrome, has become extremely relevant. Uveitis is characterized by a process of intraocular inflammation resulting from various causes. Considering psoriasis and uveitis as immune-mediated diseases, this study aims to evaluate the possible association of psoriasis and/or psoriatic arthritis with uveitis and its subtypes. Few studies have evaluated the association of uveitis and psoriasis without joint involvement. It seems that psoriasis without arthropathy is not a risk factor for the development of uveitis. Uveitis tends to develop more frequently in patients with arthropathy or pustular psoriasis than in patients with other forms of psoriasis. Ophthalmic examination should be performed periodically in patients with psoriasis and uveitis. If ophthalmopathy is diagnosed, the patient should receive adequate treatment with anti-inflammatory drugs or immunomodulators to prevent vision loss.

Clinical, dermoscopic and histopathological features of melanocytic nevi in dystrophic epidermolysis bullosa.

Epidermolysis bullosa (EB) nevi are acquired pigmented melanocytic lesions which may have clinical and dermoscopic features quite similar to those found in melanoma. More detailed information on this phenomenon is still lacking.

Inherited epidermolysis bullosa: clinical and therapeutic aspects

Inherited epidermolysis bullosa (EB) is a heterogeneous group of genetic disorders that present with skin and, in some cases, mucosal fragility, predisposing patients to the development of blisters and/or erosions after minimal trauma or friction. Children with a recurrent history of these kinds of lesions or neonates that present them in the absence of another reasonable explanation should be investigated. Diagnosis must be based on clinical and histopathological findings. To date, management of inherited EB basically consists in avoiding traumas that trigger lesions, as well as preventing infection and facilitating healing of the wounds with the systematic use of bandages.

Is there any association between Hashimoto’s thyroiditis and thyroid cancer? A retrospective data analysis

Objective To evaluate the association between Hashimotos thyroiditis (HT) and papillary thyroid carcinoma (PTC). Materials and Methods The patients were evaluated by ultrasonography-guided fine needle aspiration cytology. Typical cytopathological aspects and/or classical histopathological findings were taken into consideration in the diagnosis of HT, and only histopathological results were considered in the diagnosis of PTC. Results Among 1,049 patients with multi- or uninodular goiter (903 women and 146 men), 173 (16.5%) had cytopathological features of thyroiditis. Thirty-three (67.4%) out of the 49 operated patients had PTC, 9 (27.3%) of them with histopathological features of HT. Five (31.3%) out of the 16 patients with non-malignant disease also had HT. In the groups with HT, PTC, and PCT+HT, the female prevalence rate was 100%, 91.6%, and 77.8%, respectively. Mean age was 41.5, 43.3, and 48.5 years, respectively. No association was observed between the two diseases in the present study where HT occurred in 31.1% of the benign cases and in 27.3% of malignant cases (p = 0.8). Conclusion In spite of the absence of association between HT and PCT, the possibility of malignancy in HT should always be considered because of the coexistence of the two diseases already reported in the literature.

Piezogenic Pedal Papules

These grouped, white to flesh-colored papules on the plantar aspect of a 28-year-old womans heels appeared during weight bearing and disappeared in non–weight-bearing positions. The patient, a nurse whose work required standing for hours, noticed the lesions about a year earlier. Her medical history was unremarkable, and she was taking no medications. Her sister had similar lesions on her heels.

Multiple erythematous, shiny papules in a child.

A 9-year-old boy presented with a 1-year history of lesions on the abdomen. Initially, there was only one lesion, which was excised, and after three months, a large number of lesions appeared, scattered around the original. There was no history of local trauma. Physical examination revealed bright erythematous, violaceous papule nodules distributed around a central cicatricial lesion on the abdomen (Fig. 1a,b). Histopathologic examination showed lobules of dilated and congested capillaries in an edematous stroma covered by an epithelial collarette (Fig. 2a–c). Immunohistochemistry was positive for CD31 and CD34 (Fig. 2d,e) and negative for GLUT-1. Complete blood count, urinalysis, and abdominal ultrasonography were normal. Serology for hepatitis viruses and retroviruses were negative.

Erythematous, yellowish plaque on the face of a child

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