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Dive into the research topics where Burkhard Mielke is active.

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Featured researches published by Burkhard Mielke.


Bioorganic & Medicinal Chemistry Letters | 1997

New hetero-oligomeric peptide nucleic acids with improved binding properties to complementary DNA

Stephan Jordan; Christoph Schwemler; Winfried Dr Kosch; Axel Kretschmer; Udo Stropp; Eckhardt Schwenner; Burkhard Mielke

Abstract Hetero-oligomeric PNAs consisting of new monomeric building blocks and various amounts of N-(2-aminoethyl) glycine have been synthesized by solid-phase chemistry. Some of these new compounds show stronger binding to complementary DNA than the original PNAs, and are consequently very interesting candidates as antisense compounds for applications in therapy and in diagnostics.


Bioorganic & Medicinal Chemistry Letters | 1997

Synthesis of new building blocks for peptide nucleic acids containing monomers with variations in the backbone

Stephan Jordan; Christoph Schwemler; Winfried Dr Kosch; Axel Kretschmer; Eckhardt Schwenner; Udo Stropp; Burkhard Mielke

Abstract New PNA monomers containing aminoprolines or pyrrolidines as backbones have been synthesized. Oligomerisation was carried out on a solid support. Resistance to enzymatic degradation was tested.


Archive | 1994

Nucleic acid-binding oligomers possessing N-branching for therapy and diagnostics

Antonius L obberding; Burkhard Mielke; Christoph Schwemler; Eckhard Schwenner; Udo Stropp; Wolfgang Springer; Axel Kretschmer; Thorsten P otter


Archive | 1998

Gel formulations containing insecticide

Dietmar Kalder; Rolf Jung; Burkhard Mielke


Archive | 1994

Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik

Axel Kretschmer; Antonius Dr. Löbberding; Burkhard Mielke; Thorsten Pötter; Christoph Schwemler; Eckhard Schwenner; Wolfgang Springer; Udo Stropp


Archive | 1994

Nucleic acid binding oligomers having C-branches for therapy and diagnosis

Antonius Dr. Löbberding; Burkhard Mielke; Christoph Schwemler; Eckhard Schwenner; Udo Stropp; Wolfgang Springer; Axel Kretschmer; Thorsten Pötter


Archive | 1993

Antibacterial 7-isoindolinyl-quinolone- and naphthyridone derivatives

Thomas Philipps; Stephan Bartel; Andreas Krebs; Uwe Petersen; Thomas Schenke; Klaus-Dieter Bremm; Rainer Endermann; Karl Georg Metzger; Burkhard Mielke


Archive | 1995

Pyrido[3,2,1-i,j][3,1]benzoxazine derivatives

Werner Hallenbach; Thomas Himmler; Thomas Jaetsch; Burkhard Mielke; Klaus Dieter Bremm; Rainer Endermann; Franz Pirro; Michael Stegemann; Heinz-Georg Wetzstein


Archive | 1992

Antisense oligonucleotides with phosphoramidate internucleotide linkage throughout

Antonius Dr. Löbberding; Burkhard Mielke; Wolfgang Springer; Udo Stropp; Jörg Baumgarten; Helga Rübsamen-Waigmann; Lothar Biesert; Haryadi Suhartono


Archive | 1994

HIV antisense expression vectors

Axel Kretschmer; Horst-Peter Antonicek; Jörg Baumgarten; Antonius Dr Loebberding; Burkhard Mielke; Wolfgang Springer; Udo Stropp; Mark-Michael Dr. Struck; Lothar Biesert; Helga Rübsamen-Waigmann; Hary Suhartono; Thomas-Peter Hausner

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