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Byoung-Kwon Chun

University of Georgia

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Publication

Featured researches published by Byoung-Kwon Chun.

Nucleosides, Nucleotides & Nucleic Acids | 2005

N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus.

Jinfa Du; Laurent Hollecker; Junxing Shi; Byoung-Kwon Chun; Kyoichi A. Watanabe; Raymond F. Schinazi; Tammy Nachman; Stefania Lostia; Lieven Stuyver; Michael Otto

Novel racemic, d- and l-β-dioxolane N 4-hydroxycytosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity.

Nucleosides, Nucleotides & Nucleic Acids | 2005

Ring-expanded analogues of natural oxetanocin : (+) and (-) hydroxymethyl isodideoxyadenosine

Byoung-Kwon Chun; Jean John Vadakkan; Vasu Nair

New enantiomeric isonucleoside analogues related to natural oxetanocin have been synthesized from D-glucosamine and D-glucose. The structures of the target compounds were confirmed by NMR, HRMS, UV, single crystal X-ray, and optical rotation data. Stability studies with respect to purine nucleoside phosphorylase and adenosine deaminase show that these compounds are not substrates. Antiviral results are discussed.

Nucleosides, Nucleotides & Nucleic Acids | 2005

Unusual olefin formation by PhSe-F trans-elimination

Jinfa Du; Junxing Shi; Byoung-Kwon Chun; Ann Hobbs; Laurent Hollecker; Kyoichi A. Watanabe

A new approach to the synthesis of 2′,3′-didehydro-2′,3′-dideoxynucleosides was described in excellent yield through unusual olefin formation by PhSe-F trans-elimination.

Archive | 2009

Synthesis of purine nucleosides

Byoung-Kwon Chun; Jinfa Du; Suguna Rachakonda; Bruce S. Ross; Michael J. Sofia; Ganapati Reddy Pamulapati; Wonsuk Chang; Hai-Ren Zhang; Dhanapalan Nagarathnam

Archive | 2005

Preparation of 2'-fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives

Byoung-Kwon Chun; Peiyuan Wang; Jinfa Du; Suguna Rachakonda

ACS Medicinal Chemistry Letters | 2011

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection.

Wonsuk Chang; Donghui Bao; Byoung-Kwon Chun; Devan Naduthambi; Dhanapalan Nagarathnam; Suguna Rachakonda; P. Ganapati Reddy; Bruce S. Ross; Hai-Ren Zhang; Shalini Bansal; Christine Espiritu; Meg Keilman; Angela M. Lam; Congrong Niu; Holly M. Micolochick Steuer; Phillip A. Furman; Michael Otto; Michael J. Sofia

Journal of Medicinal Chemistry | 2014

Use of 2'-spirocyclic ethers in HCV nucleoside design.

Jinfa Du; Byoung-Kwon Chun; Ralph T. Mosley; Shalini Bansal; Haiying Bao; Christine Espiritu; Angela M. Lam; Eisuke Murakami; Congrong Niu; Holly M. Micolochick Steuer; Phillip A. Furman; Michael J. Sofia

Archive | 2010

And process for the preparation of n-[(2'r)-2'-deoxy-2'-fluoro-2'-methyl-p-phenyl-5'-uridylyl]-l-alanine 1-methylethyl ester

Bruce S. Ross; Michael J. Sofia; Ganapati Reddy Pamulapati; Suguna Rachakonda; Hai-Ren Zhang; Byoung-Kwon Chun; Peiyuan Wang

Archive | 2017

Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate

Bruce S. Ross; Michael J. Sofia; Ganapati Reddy Pamulapati; Suguna Rachakonda; Hai-Ren Zhang; Byoung-Kwon Chun; Peiyuan Wang

Archive | 2017

N- [ (2 R) -2 -DEOXY-2 -FLUORO-2 -METHYL-P-PHENYL-5 -URIDYLYL] - L-ALANINE 1-METHYLETHYL ESTER AND PROCESS FOR ITS PRODUCTION N-[(2R)-2--2--2--P--5-]-L- 1-

Bruce S Ross S; Michael J. Sofia; Ganapati Reddy Pamulapati; Suguna Rachakonda; Hai-Ren Zhang; Byoung-Kwon Chun; Peiyuan Wang

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Suguna Rachakonda

Princeton University

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Bruce S. Ross

Isis Pharmaceuticals

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Michael J. Sofia

Princeton University

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Hai-Ren Zhang

Princeton University

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Peiyuan Wang

University of Georgia

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Jinfa Du

Princeton University

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Dhanapalan Nagarathnam

Princeton University

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Wonsuk Chang

Johns Hopkins University

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Jiang Zhu

Hoffmann-La Roche

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Justin Vitale

Hoffmann-La Roche

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