C. Bombonato

Dermoscopic "signature" pattern of pigmented and nonpigmented facial actinic keratoses

Skin A IR M Fund Conf CLINICAL PRESENTATION An 86-year-old man with skin phototype I/II presented with multiple flat, scaly, nonpigmented actinic keratoses (AKs) on the face and scalp (Fig 1, A). A clinically inconspicuous 2-mm scaly pink papule was also noted on the left nasal sidewall (Fig 1, A, inset). The second patient, a 74-year-old man with skin phototype II/III presented with numerous flat, scaly, pigmented facial AKs (Fig 1, B).

Association between dermoscopic and reflectance confocal microscopy features of cutaneous melanoma with BRAF mutational status

Melanomas harbouring common genetic mutations might share certain morphological features detectable with dermoscopy and reflectance confocal microscopy. BRAF mutational status is crucial for the management of metastatic melanoma.

Trichoblastoma: is a clinical or dermoscopic diagnosis possible?

Trichoblastoma is a rare benign skin tumour that must be differentiated from basal cell carcinoma for its benign course and favourable outcome.

In vivo dermoscopic and confocal microscopy multistep algorithm to detect in situ melanomas

Although several dermoscopic features of in situ melanoma have been identified, data on confocal features of in situ melanoma are still lacking.

Pigmented eccrine poroma: dermoscopic and confocal features.

Eccrine poroma is a rare benign adnexal tumor of epithelial cells originating from the terminal ductal portion of the sweat glands that is typically located on palms and soles, although other cutaneous sites can be affected [1]. It is usually nonpigmented even if there is a pigmented variant that corresponds to 17% of cases and it is usually underdiagnosed, since it is mistakenly confused with other pigmented tumors [2,3]. Dermoscopy and reflectance confocal microscopy (RCM) may assist in the correct diagnosis of this tumor. Herein, we report one case of pigmented eccrine poroma (PEP) that simulated clinically a cutaneous melanoma or a basal cell carcinoma. Dermoscopy and RCM excluded the possibilities of those two diagnoses; the overall confocal findings were suggestive for a benign epithelial tumor. Histology was fundamental to diagnose this lesion as a pigmented eccrine poroma. Even if the diagnosis of eccrine poroma remains histopathological still, as in this case report, noninvasive tools such as dermoscopy and RCM examinations can be of help to rule out the diagnosis of melanoma. Larger studies on this rare pigmented variant of eccrine poroma could shed new light on the identification of specific diagnostic dermoscopic and confocal features.

Tracking actinic keratosis of face and scalp treated with 0.015% ingenol mebutate to identify clinical and dermoscopic predictors of treatment response

Ingenol mebutate (IngMeb) 0.015% gel is an approved field treatment option for non‐hyperkeratotic non‐hypertrophic actinic keratosis (AK) of face and scalp. Efficacy of IngMeb has been assessed only on a clinical ground, in the majority of studies. Dermoscopy is a pivotal tool for the diagnosis of AK, while its role in evaluating the response to non‐surgical therapies for AK has not been fully defined.

Baldness and scalp melanoma

Nearly 20% of melanomas occur on the head and neck area1 but only 2-5% arise on the scalp.2 Several studies reported a worse prognosis of scalp melanoma compared to other body sites, being unclear the reason for this phenomenon.3 Melanoma and non-melanoma skin cancer of the scalp are most frequent in bald men older than 65 years. This article is protected by copyright. All rights reserved.

Basal cell carcinoma: the utility of in vivo and ex vivo confocal microscopy

The use of confocal microscopy is possible using two different modalities: first, at patients bedside for a rapid in vivo diagnosis of basal cell carcinoma and second, in the operating room directly on freshly excised specimen for a fast ex vivo margin‐controlled surgery. In the current review, we report the main application of confocal microscopy for basal cell carcinoma diagnosis and management in both modalities.

Sclerosing nevus with pseudomelanomatous features: Dermoscopic and confocal aspects

Sclerosing nevus with pseudomelanomatous features (SNPFs) is a clinical and pathologic entity that mimics melanoma both clinically and histologically.

Integration of dermoscopy and reflectance confocal microscopy for distinguishing melanomas from nevi of the breast area

Nevi of special sites encompass a class of benign lesions characterized by the presence of atypical clinical and histopathological features that can be difficult to distinguish from melanoma. Dermoscopy and reflectance confocal microscopy may improve the clinical assessment of melanocytic lesions to avoid unnecessary excisions.