C.C. Okoye
Case Western Reserve University
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Featured researches published by C.C. Okoye.
Cancers | 2015
Kylie H. Kang; C.C. Okoye; Ravi Patel; Shankar Siva; Tithi Biswas; Min Yao; Mitchell Machtay; Simon S. Lo
Stereotactic body radiotherapy (SBRT) has become a standard treatment option for early stage, node negative non-small cell lung cancer (NSCLC) in patients who are either medically inoperable or refuse surgical resection. SBRT has high local control rates and a favorable toxicity profile relative to other surgical and non-surgical approaches. Given the excellent tumor control rates and increasing utilization of SBRT, recent efforts have focused on limiting toxicity while expanding treatment to increasingly complex patients. We review toxicities from SBRT for lung cancer, including central airway, esophageal, vascular (e.g., aorta), lung parenchyma (e.g., radiation pneumonitis), and chest wall toxicities, as well as radiation-induced neuropathies (e.g., brachial plexus, vagus nerve and recurrent laryngeal nerve). We summarize patient-related, tumor-related, dosimetric characteristics of these toxicities, review published dose constraints, and propose strategies to reduce such complications.
Technology in Cancer Research & Treatment | 2016
C.C. Okoye; Ravi Patel; Shaakir Hasan; Tarun Kanti Podder; Anton Khouri; Jeffrey Fabien; Y. Zhang; Donald Dobbins; Jason W. Sohn; Jiankui Yuan; Min Yao; Mitchell Machtay; Andrew E. Sloan; Jonathan P. Miller; Simon S. Lo
Stereotactic body radiation therapy (SBRT) is an emerging technology for the treatment of spinal metastases, although the dosimetric impact of the calculation method on spinal dose distribution is unknown. This study attempts to determine whether CyberKnife (CK)-based SBRT using a Ray Tracing (RyTc) algorithm is comparable dosimetrically to that of Monte Carlo (MC) for thoracic spinal lesions. Our institutional CK-based SBRT database for thoracic spinal lesions was queried and a cohort was generated. Patients were planned using RyTc and MC algorithms using the same beam angles and monitor units. Dose–volume histograms of the planning target volume (PTV), spinal cord, esophagus, and skin were generated, and dosimetric parameters were compared. There were 37 patients in the cohort. The average percentage volume of PTV covered by the prescribed dose with RyTc and MC algorithms was 91.1% and 80.4%, respectively (P < .001). The difference in average maximum spinal cord dose between RyTc and MC plans was significant (1126 vs 1084 cGy, P = .004), with the MC dose ranging from 18.7% below to 13.8% above the corresponding RyTc dose. A small reduction in maximum skin dose was also noted (P = .017), although no difference was seen in maximum esophageal dose (P = .15). Only PTVs smaller than 27 cm3 were found to correlate with large (>10%) changes in dose to 90% of the volume (P = .014), while no correlates with the average percentage volume of PTV covered by the prescribed dose were demonstrated. For thoracic spinal CK-based SBRT, RyTc computation may overestimate the MC calculated average percentage volume of PTV covered by the prescribed dose and have unpredictable effects on doses to organs at risk, particularly the spinal cord. In this setting, use of RyTc optimization should be limited and always verified with MC.
Head and Neck-journal for The Sciences and Specialties of The Head and Neck | 2017
C.C. Okoye; Jessica Bucher; Curtis Tatsuoka; Sahil A. Parikh; Guilherme H. Oliveira; Michael K. Gibson; Mitchell Machtay; Min Yao; Chad A. Zender; J.A. Dorth
The underlying contributors to cardiovascular disease (CVD) in patients with head and neck squamous cell carcinoma (HNSCC) are poorly characterized.
Neurosurgery | 2018
C.C. Okoye; Ravi Patel; Arjun Sahgal; Eric L. Chang; Simon S. Lo
∗St. Bernards Medical Group, Jonesboro, Arkansas; ‡Department of Human Oncology, University of Wisconsin, Madison, Wisconsin; §Department of Radiation Oncology, Sunnybrook Health Science Centre, University of Toronto, Toronto, Canada; ¶Department of Radiation Oncology, University of Southern California, Los Angeles, California; ||Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington
World Neurosurgery | 2015
Shaakir Hasan; Michael Young; Trevine Albert; Ashish H. Shah; C.C. Okoye; Amade Bregy; Simon S. Lo; Fazilat Ishkanian; Ricardo J. Komotar
Journal of Clinical Oncology | 2017
C.C. Okoye; Jessica Bucher; Guiherme Oliveira; Sahil A. Parikh; Min Yao; Mitchell Machtay; J.A. Dorth
International Journal of Radiation Oncology Biology Physics | 2016
C.C. Okoye; Yiran Zheng; R.F. Muzic; Min Yao; J.A. Dorth
Archive | 2015
Shaakir Hasan; C.C. Okoye; Rutulkumar Patel; Tithi Biswas; Min Yao; Mitchell Machtay; Simon S. Lo
International Journal of Radiation Oncology Biology Physics | 2014
C.C. Okoye; Guilherme H. Oliveira; Sahil A. Parikh; J.A. Dorth
International Journal of Radiation Oncology Biology Physics | 2014
Rutulkumar Patel; C.C. Okoye; H. Lindsay; Tithi Biswas