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Dive into the research topics where C Croia is active.

Publication


Featured researches published by C Croia.


Annals of the New York Academy of Sciences | 2010

Pathophysiology of fibromyalgia: a comparison with the tension-type headache, a localized pain syndrome.

Cristina Iannuccelli; M. Di Franco; Cristiano Alessandri; Maria Paola Guzzo; C Croia; F. Di Sabato; M. Foti; Guido Valesini

Fibromyalgia (FM) is thought to occur because of the combination of interactions among neurotransmitters, such as neuropeptide Y (NPY), stressors, hormones, cytokines, and both the immune and sympathetic nervous systems. The aim of this study was to evaluate serum concentrations of cytokines, antipolymer antibodies (APA), and NPY in 51 patients with FM, 25 with tension‐type headache (TTH), and 15 healthy controls. Serum concentrations of eight different cytokines, APA and NPY, were measured. Interleukin (IL)‐1RA, IL‐6, IL‐10, and tumor necrosis factor‐alpha were higher in serum of FM patients compared with TTH patients and a significant correlation between IL‐10 and Fibromyalgia Impact Questionnaire score was observed. There was a significant difference between FM and TTH versus controls in NPY levels, but not in APA levels. Cytokines and NPY take part in pain modulation and even if they are altered in FM they cannot be considered as measurable biomarkers of disease.


Archive | 2010

Pathophysiology of fibromyalgia: A comparison with the tension-type headache, a localized pain syndrome: Annals of the New York Academy of Sciences

Cristina Iannuccelli; M. Di Franco; Cristiano Alessandri; Maria Paola Guzzo; C Croia; F. Di Sabato; M. Foti; Guido Valesini

Fibromyalgia (FM) is thought to occur because of the combination of interactions among neurotransmitters, such as neuropeptide Y (NPY), stressors, hormones, cytokines, and both the immune and sympathetic nervous systems. The aim of this study was to evaluate serum concentrations of cytokines, antipolymer antibodies (APA), and NPY in 51 patients with FM, 25 with tension‐type headache (TTH), and 15 healthy controls. Serum concentrations of eight different cytokines, APA and NPY, were measured. Interleukin (IL)‐1RA, IL‐6, IL‐10, and tumor necrosis factor‐alpha were higher in serum of FM patients compared with TTH patients and a significant correlation between IL‐10 and Fibromyalgia Impact Questionnaire score was observed. There was a significant difference between FM and TTH versus controls in NPY levels, but not in APA levels. Cytokines and NPY take part in pain modulation and even if they are altered in FM they cannot be considered as measurable biomarkers of disease.


Annals of the Rheumatic Diseases | 2009

Nucleosome accumulation and reduction of C-reactive protein are associated with the generation of anti-nuclear antibodies in patients with rheumatoid arthritis treated with adalimumab, but not with etanercept

Roberta Priori; Cristiano Alessandri; L. Magrini; Emanuele Cassarà; Fulvia Ceccarelli; Mariagrazia Modesti; C Croia; Michele Bombardieri; G. Valesini

During the last decade, three tumour necrosis factor (TNF)α antagonists have been approved for the treatment of moderate to severe rheumatoid arthritis (RA).1 These new drugs, while extremely powerful, can induce puzzling biological phenomena such as the production of autoantibodies whose extent seems to vary accordingly to the drug used.2,3 A dysregulation of apoptosis with exposition of nuclear antigens and consequent rapid (within hours) accumulation of nucleosomes has been evoked to explain autoantibody occurrence in patients treated with infliximab.4 In addition (or in alternative) to an increased release of nuclear antigens, a defect in clearance mechanisms can play a role in the generation of autoantibodies.5 We studied autoantibody profiles (anti-nuclear antibody (ANA), anti-double stranded …


Clinical and Experimental Rheumatology | 2012

The role of eight polymorphisms in three candidate genes in determining the susceptibility, phenotype, and response to anti-TNF therapy in patients with rheumatoid arthritis.

Fulvia Ceccarelli; S D'Alfonso; Carlo Perricone; Y Carlomagno; Cristiano Alessandri; C Croia; N Barizzone; Carlomaurizio Montecucco; Mauro Galeazzi; Gd Sebastiani; G. Minisola; Ugo Fiocco; Guido Valesini


Clinical and Experimental Rheumatology | 2010

Exploratory data analysis on the effects of non pharmacological treatment for knee osteoarthritis

Fulvia Ceccarelli; Carlo Perricone; Cristiano Alessandri; Mariagrazia Modesti; Annamaria Iagnocco; C Croia; Manuela Di Franco; Guido Valesini


Rheumatology | 2009

Nailfold capillaroscopy abnormalities are associated with the presence of anti-endothelial cell antibodies in Sjogren's syndrome

Valeria Riccieri; I. Sciarra; Fulvia Ceccarelli; Cristiano Alessandri; C Croia; M. Vasile; Maria Grazia Modesti; Roberta Priori; Guido Valesini


Rheumatology | 2011

Rheumatoid arthritis - aetiopathogenesis and animal models 87. Do We Need to Redefine Seropositivity in RA?

Rizwan Rajak; Nicholas Amos; Jeremy Camilleri; Peter Charles; Darren Plant; Muslima Chowdhury; Jane Worthington; P J Venables; Alessandra Marrelli; Michele Bombardieri; Steven Kelly; Paola Cipriani; Roberto Giacomelli; Costantino Pitzalis; C Croia; Barbara Serafini; Stephen Kelly; Eliana M. Coccia; Martina Severa; Aloisi Francesca; Grainne Murphy; Arun H. S. Kumar; Fergus Shanahan; Sinead Harney; Michael G. Molloy; Noel M. Caplice


XLV congresso Nazionale della Società Italiana di Reumatologia | 2008

anticorpi anti-cellule endoteliali nella cardiopatia reumatica

Cristiano Alessandri; Guido Valesini; H Abuhadi; V Scalzi; C Croia; Aal ansi


Archive | 2008

livelli sierici di citochine nella fibromialgia: confronto con la cefalea tensiva (sindrome dolorosa localizzata)

Cristiano Alessandri; Guido Valesini; Manuela Di Franco; sabato F Di; Cristina Iannuccelli; Maria Paola Guzzo; C Croia; M. Foti


Archive | 2008

Il reumatismo articolare acuto negli anni 2000

Cristiano Alessandri; Guido Valesini; V Scalzi; C Croia

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Fulvia Ceccarelli

Sapienza University of Rome

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M. Foti

Sapienza University of Rome

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Maria Paola Guzzo

Sapienza University of Rome

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Carlo Perricone

Sapienza University of Rome

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F. Di Sabato

Sapienza University of Rome

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M. Di Franco

Sapienza University of Rome

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Manuela Di Franco

Sapienza University of Rome

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