C. Emily Durbin

Temperamental emotionality in preschoolers and parental mood disorders.

A number of models developed in the adult psychopathology literature (i.e., L. A. Clark & D. Watson, 1991) have asserted that low levels of positive emotionality (PE) are predisposing factors or precursors for depression and represent a form of temperamental risk for depression. Further support for this claim would derive from evidence linking low PE to known indicators of risk for depression. The authors examined the association between temperamental emotionality in young children and parental mood disorders. One hundred unselected preschool-aged children completed a battery of emotion-eliciting tasks tapping aspects of PE, negative emotionality (NE), and behavioral inhibition (BI). Parental psychopathology was assessed with semistructured diagnostic interviews. Low PE in children was associated with maternal, but not paternal, mood disorder. The low PE-maternal depression link was relatively specific, as there were few associations between low PE and other forms of parental psychopathology or between NE and BI and parental mood disorders.

Stability of laboratory-assessed temperamental emotionality traits from ages 3 to 7

A key component of temperament models is the presumed temporal stability of temperament traits. Although a substantial literature using parent report measures has addressed this claim, very few investigations have examined the stability of temperament using alternative measurement strategies, particularly those that involve direct assessment of emotional expressions. This study reports on the relative stability and heterotypic continuity of temperament traits measured via laboratory tasks and maternal report in a sample of children assessed at ages 3, 5, and 7, focusing on Positive Emotionality and Negative Emotionality. Relative stability of Positive Emotionality and Negative Emotionality traits ranged from moderate to high for laboratory and maternal report measures. Measures of emotional expressions exhibited levels of stability comparable to or higher than traits defined by other behavioral patterns (e.g., sociability and engagement).

Temperamental Emotionality in Preschool-Aged Children and Depressive Disorders in Parents: Associations in a Large Community Sample

Researchers and clinicians have long hypothesized that there are temperamental vulnerabilities to depressive disorders. Despite the fact that individual differences in temperament should be evident in early childhood, most studies have focused on older youth and adults. We hypothesized that if early childhood temperament is a risk factor for depressive disorders, it should be associated with better established risk markers, such parental depression. Hence, we examined the associations of laboratory-assessed positive emotionality (PE), negative emotionality (NE), and behavioral inhibition (BI) with semistructured interview-based diagnoses of parental depressive disorders in a community sample of 536 3-year old children. Children with higher levels of NE and BI had higher probabilities of having a depressed parent. However, both main effects were qualified by interactions with child PE. At high and moderate (but not low) levels of child PE, greater NE and BI were associated with higher rates of parental depression. Conversely, at low (but not high and moderate) levels of child NE, low PE was associated with higher rates of parental depression. Child temperament was not associated with parental anxiety and substance use disorders. These findings indicate that laboratory-assessed temperament in young children is associated with parental depressive disorders; however, the relations are complex, and it is important to consider interactions between temperament dimensions rather than focusing exclusively on main effects.

Positive emotionality at age 3 predicts cognitive styles in 7-year-old children

This study examined associations between temperament at age 3 and depressotypic cognitive styles at age 7 in a community sample of children. Sixty-four preschool aged children were assessed for positive emotionality (PE) and negative emotionality (NE) using a standardized battery of laboratory tasks and naturalistic home observations. At follow-up 4 years later, the children completed laboratory tasks designed to tap helplessness in social and problem-solving situations, positive and negative information-processing biases, and self-reports of attributional style. Lower PE at age 3 predicted greater helplessness in the interpersonal task and decreased positive schematic processing. There was little evidence for a relationship between NE and depressotypic cognitive styles. Our findings are consistent with the hypothesis that some portion of cognitive vulnerability to depression may stem from early-emerging differences in the expression of positive emotions.

Preschoolers’ Observed Temperament and Psychiatric Disorders Assessed with a Parent Diagnostic Interview

Evidence supports the role of temperament in the origins of psychiatric disorders. However, there are few data on associations between temperament and psychiatric disorders in early childhood. A community sample of 541 three-year-old preschoolers participated in a laboratory temperament assessment, and caregivers were administered a structured diagnostic interview on preschool psychopathology. In bivariate analyses, temperamental dysphoria and low exuberance were associated with depression; fear, low exuberance, and low sociability were associated with anxiety disorders; and disinhibition and dysphoria were associated with oppositional defiant disorder. Although there were no bivariate associations between temperament and attention-deficit/hyperactivity disorder, disinhibition emerged as a unique predictor in multivariate analyses. Findings indicate that the pattern of relations between temperament and psychopathology in older youth and adults is evident as early as age 3.

The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene–environment correlation and gene–environment interaction

Objectives Research implicates the A1 allele of the dopamine D2 receptor gene (DRD2) Taq1A polymorphism in the development of depression and anxiety. Furthermore, recent papers suggest that children with A1 allele of this gene may receive less positive parenting, and that the effects of this gene on child symptoms may be moderated by parenting. We sought to replicate and extend these findings using behavioral measures in a nonclinical sample of young children. Methods In a sample of 473 preschool-aged children and their mothers, structured clinical interview measures and maternal reports of child symptoms were collected, and standardized observations of parent–child interactions were conducted. Results An association was detected between the DRD2 A1 allele and symptoms of depression and anxiety indexed using interview and parent report methods. As found in previous reports, children with the DRD2 A1 allele received less supportive parenting and displayed higher levels of negative emotionality during parent–child interactions. Tests of mediation and moderation were conducted. Conclusion We found associations between the DRD2 A1 allele and early-emerging anxious and depressive symptoms in a community sample of preschool-aged children, and evidence of a gene–environment correlation and moderation of the main effect of child genotype on child symptoms by parenting.

Ten-year stability of personality disorders among outpatients with mood disorders.

One of the core propositions in most clinical and descriptive models of personality disorders (PDs) is that these conditions are stable over time. However, the available empirical literature suggests that PDs are far less stable than these models imply. The present study examines the 10-year stability of PDs in a sample of depressed outpatients who were assessed for the full range of Axis II conditions across 5 assessments. Three primary issues are addressed: (a) the stability of categorical PD diagnoses, (b) the relative stability of dimensional PD traits, and (c) the absolute stability of PD traits. The stability of PD diagnoses was poor to fair, and the stability of dimensional PD traits was fair to moderate. Growth curve analyses revealed complex patterns of change in absolute scores for PD traits across the 10-year interval. Stability of PDs was generally comparable to that of anxiety disorder diagnoses and normal personality traits.

Low positive emotionality in young children: Association with EEG asymmetry

Low positive emotionality (PE; e.g., listlessness, anhedonia, and lack of enthusiasm) has been hypothesized to be a temperamental precursor or risk factor for depression. The present study sought to evaluate the validity of this hypothesis by testing whether low PE children have similar external correlates as individuals with depression. This paper focused on the external correlate of EEG asymmetry. Previous studies have reported that individuals at risk for depression exhibited a frontal EEG asymmetry (greater right than left activity). Others have reported an association with posterior asymmetries (greater left than right activity). In the present study, children classified as having low PE at age 3 exhibited an overall asymmetry at age 5-6 with less relative activity in the right hemisphere. This asymmetry appeared to be largely due to a difference in the posterior region because children with low PE exhibited decreased right posterior activity whereas high PE children exhibited no posterior asymmetry. These findings support the construct validity of the hypothesis that low PE may be a temperamental precursor or risk factor for depression.

Reconceptualizing antisocial deviance in neurobehavioral terms

We propose that neuroscientific understanding of antisocial behavior can be advanced by focusing programmatic efforts on neurobehavioral trait constructs, that is, individual difference constructs with direct referents in neurobiology as well as behavior. As specific examples, we highlight inhibitory control and defensive reactivity as two such constructs with clear relevance for understanding antisocial behavior in the context of development. Variations in inhibitory control are theorized to reflect individual differences in the functioning of brain systems that operate to guide and inhibit behavior and regulate emotional response in the service of nonimmediate goals. Variations in defensive reactivity are posited to reflect individual differences in the sensitivity of the brains aversive motivational (fear) system. We describe how these constructs have been conceptualized in the adult and child literatures and review work pertaining to traditional psychometric (rating and behaviorally based) assessment of these constructs and their known physiological correlates at differing ages as well as evidence linking these constructs to antisocial behavior problems in children and adults. We outline a psychoneurometric approach, which entails systematic development of neurobiological measures of target trait constructs through reference to psychological phenotypes, as a paradigm for linking clinical disorders to neurobiological systems. We provide a concrete illustration of this approach in the domain of externalizing proneness and discuss its broader implications for research on conduct disorder, antisocial personality, and psychopathy.

Personality and Psychopathology: A Stagnant Field in Need of Development

A dominant paradigm in psychopathology research proposes that individual differences in personality are centrally involved in the origins and manifestations of psychopathology, and structural models of personality and psychopathology have been extremely useful in helping to organize associations among many traits and disorders. However, these models merely describe patterns of covariation; they do not explain the processes by which these patterns emerge. We argue that the field is stagnated, as it is overly focused on the demonstration of concurrent associations and on confirming a spectrum model that proposes traits and disorders are manifestations of the same underlying constructs. We contend that if the field is to move towards an understanding of causal processes, it must integrate knowledge and principles of personality development and developmental psychopathology. To begin this integration, we review (i) normative trends in personality change, (ii) age–related changes in the prevalence of disorders, and (iii) the impact of onset and chronicity on the severity of disorders. We propose several developmental processes that may contribute to the co–development of personality and psychopathology. We then present novel empirical findings to illustrate how a developmental perspective on traits and disorders can inform new hypotheses and propose principles and hypotheses that should guide future research. Copyright