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Dive into the research topics where C. Guarner is active.

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Featured researches published by C. Guarner.


Gastroenterology | 2009

Acute Hemodynamic Response to β-Blockers and Prediction of Long-term Outcome in Primary Prophylaxis of Variceal Bleeding

Càndid Villanueva; Carles Aracil; Alan Colomo; Virginia Hernández–Gea; Josep M. López–Balaguer; Cristina Alvarez–Urturi; Xavier Torras; Joaquim Balanzó; C. Guarner

BACKGROUND & AIMS Studies of variceal bleeding have shown that a hemodynamic response to treatment of portal hypertension is appropriate when the hepatic venous pressure gradient (HVPG) decreases below 12 mmHg or by > 20% from baseline. However, in primary prophylaxis, many nonresponders do not bleed and 2 invasive procedures are needed to assess response. We investigated the long-term prognostic value of an acute response to beta-blockers and whether the target reduction in HVPG can be improved in primary prophylaxis. METHODS An initial hemodynamic study was performed in patients with large varices and without previous bleeding. After baseline measurements were made, propranolol was administered intravenously and measurements were repeated 20 minutes later. Patients were given nadolol daily and a second hemodynamic study was performed. RESULTS Of 105 patients, 15% had variceal bleeding. Using receiver operating characteristic curve analysis, a decrease of HVPG > or = 10% was the best value to predict bleeding. In the initial study, 75 patients (71%) were responders (HVPG decreased to < or = 12 mmHg or by > or = 10%) and had a lower probability of first bleeding than nonresponders (4% vs 46% at 24 months; P < .001). Acute responders also had a lower risk of developing ascites (P = .001). Chronic responders had a lower probability of bleeding than nonresponders (P < .001). There was a correlation between acute and chronic changes in HVPG (r = 0.62; P = .01). CONCLUSION The acute hemodynamic response to beta-blockers can be used to predict the long-term risk of first bleeding. An HVPG reduction > 10% from baseline is the best target to define response in primary prophylaxis.


Journal of Hepatology | 2010

Secondary bacterial peritonitis in cirrhosis: A retrospective study of clinical and analytical characteristics, diagnosis and management

Germán Soriano; Jose Castellote; Cristina Alvarez; A. Girbau; Jordi Gordillo; Carme Baliellas; Meritxell Casas; Carles Pons; Eva María Román; Sandra Maisterra; Xavier Xiol; C. Guarner

BACKGROUND & AIMS Secondary bacterial peritonitis in cirrhotic patients is an uncommon entity that has been little reported. Our aim is to analyse the frequency, clinical characteristics, treatment and prognosis of patients with secondary peritonitis in comparison to those of patients with spontaneous bacterial peritonitis (SBP). METHODS Retrospective analysis of 24 cirrhotic patients with secondary peritonitis compared with 106 SBP episodes. RESULTS Secondary peritonitis represented 4.5% of all peritonitis in cirrhotic patients. Patients with secondary peritonitis showed a significantly more severe local inflammatory response than patients with SBP. Considering diagnosis of secondary peritonitis, the sensitivity of Runyons criteria was 66.6% and specificity 89.7%, Runyons criteria and/or polymicrobial ascitic fluid culture were present in 95.6%, and abdominal computed tomography was diagnostic in 85% of patients in whom diagnosis was confirmed by surgery or autopsy. Mortality during hospitalization was higher in patients with secondary peritonitis than in those with SBP (16/24, 66.6% vs. 28/106, 26.4%) (p<0.001). There was a trend to lower mortality in secondary peritonitis patients who underwent surgery (7/13, 53.8%) than in those who received medical treatment only (9/11, 81.8%) (p=0.21). Considering surgically treated patients, the time between diagnostic paracentesis and surgery was shorter in survivors than in non-survivors (3.2+/-2.4 vs. 7.2+/-6.1 days, p=0.31). CONCLUSIONS Secondary peritonitis is an infrequent complication in cirrhotic patients but mortality is high. A low threshold of suspicion on the basis of Runyons criteria and microbiological data, together with an aggressive approach that includes prompt abdominal computed tomography and early surgical evaluation, could improve prognosis in these patients.


Liver International | 2014

Drugs plus ligation to prevent rebleeding in cirrhosis: an updated systematic review.

Ángela Puente; Virginia Hernández-Gea; Isabel Graupera; Marta Roque; Alan Colomo; Maria Poca; Carles Aracil; Ignasi Gich; C. Guarner; Càndid Villanueva

Combined therapy with endoscopic variceal ligation (EVL) and β‐blockers ± isosorbide mononitrate (ISMN) is currently recommended to prevent variceal rebleeding. However, the role of this combined therapy has been challenged by some studies. We performed a systematic review to assess the value of combined therapy with EVL and β‐blockers ± ISMN as compared with each treatment alone to prevent rebleeding.


Alimentary Pharmacology & Therapeutics | 2009

Clinical trial: a randomized controlled study on prevention of variceal rebleeding comparing nadolol + ligation vs. hepatic venous pressure gradient-guided pharmacological therapy

Càndid Villanueva; Carles Aracil; Alan Colomo; J. M. Lopez-Balaguer; M. Piqueras; B. Gonzalez; Xavier Torras; C. Guarner; Joaquim Balanzó

Background  Hepatic venous pressure gradient (HVPG) monitoring of therapy to prevent variceal rebleeding provides strong prognostic information. Treatment of nonresponders to β‐blockers ± nitrates has not been clarified.


Alimentary Pharmacology & Therapeutics | 2010

Toll-like receptor 4 D299G polymorphism and the incidence of infections in cirrhotic patients.

C. Guarner-Argente; E. Sánchez; S. Vidal; Eva Román; Mar Concepción; Maria A. Poca; D. Sánchez; C. Juárez; Germán Soriano; C. Guarner

Aliment Pharmacol Ther 31, 1192–1199


Gastroenterology | 1998

Final results of a prospective and randomized trial evaluating endoscopic hemoclip for bleeding peptic ulcer

M. Sâbat; Cándido Villanueva; Jordi Ortiz; Germán Soriano; Sergio Sainz; Xavier Torras; Xavier Cussó; C. Guarner; J. Balanzó


Journal of Hepatology | 2007

[220] INTRAVENOUS ALBUMIN IS NOT NECESSARY IN CIRRHOTIC PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS AND LOW-RISK OF MORTALITY

Meritxell Casas; Germán Soriano; E. Ayala; C. Guarner-Argente; I. Ordas; J. Merce; J. Balanzó; C. Guarner


Journal of Hepatology | 2009

104 RENAL FAILURE AND MORTALITY IN CIRRHOTIC PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS AND LOW RISK OF MORTALITY NON-TREATED WITH ALBUMIN

Maria A. Poca; M. Concepción; Meritxell Casas; Cristina Alvarez; Jordi Gordillo; C. Guarner-Argente; P. Gonçalves; V. Hernandez; Germán Soriano; C. Guarner


Journal of Hepatology | 2000

Outpatient large volume paracentesis in cirrhotic patients with tenseascites: Safety and cost compared with an inpatient schedule

M. Planella; X. Torras; L. Kolle; X. Cussó; Josep M. Dedeu; Josep Miñana; Cristina Gómez; Germán Soriano; C. Guarner; J. Balanzó


Journal of Hepatology | 1998

A randomized trial comparing endoscopic ligation with nadolol plus isosorbide-5-mononitrate for the prevention of variceal rebleeding, preliminary results

Adolfo Gallego; Càndid Villanueva; Jordi Ortiz; Josep Miñana; Germán Soriano; Elena Ricart; X. Torras; Sergio Sainz; L. Kolle; C. Guarner; J. Balanzó

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Germán Soriano

Instituto de Salud Carlos III

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J. Balanzó

Autonomous University of Barcelona

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Sergio Sainz

Autonomous University of Barcelona

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E. Román

Instituto de Salud Carlos III

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J.C. Nieto

Autonomous University of Barcelona

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Maria A. Poca

Autonomous University of Barcelona

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Elisabet Sánchez

Instituto de Salud Carlos III

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Jordi Gordillo

Autonomous University of Barcelona

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Meritxell Casas

Autonomous University of Barcelona

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