C. K. Lin
University of Hong Kong
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Featured researches published by C. K. Lin.
Vox Sanguinis | 2002
Ck Lee; Pak-Leung Ho; N.K. Chan; A. Mak; J. Hong; C. K. Lin
Background and Objectives Despite improved methods for detecting bacterial contamination of blood products, bacterial sepsis remains a significant risk in blood transfusion. This study was undertaken to investigate whether adopting a different skin disinfection protocol could reduce the rate of bacterial contamination of platelet concentrates.
The Journal of Infectious Diseases | 2012
Herman Tse; Jessie Y.J. Bao; Mark R. Davies; Peter G. Maamary; Hoi-Wah Tsoi; Amy Hin Yan Tong; Tom Cc Ho; C. K. Lin; Christine M. Gillen; Timothy C. Barnett; Jonathan H. K. Chen; Mianne Lee; Wing-Cheong Yam; Chi-Kin Wong; Cheryl-lynn Y. Ong; Yee-Wai Chan; Cheng-Wei Wu; Tony Ng; Wilina Lim; Thomas Tsang; Cindy W. S. Tse; Gordon Dougan; Mark J. Walker; Si Lok; Kwok-Yung Yuen
A scarlet fever outbreak occurred in Hong Kong in 2011. The majority of cases resulted in the isolation of Streptococcus pyogenes emm12 with multiple antibiotic resistances. Phylogenetic analysis of 22 emm12 scarlet fever outbreak isolates, 7 temporally and geographically matched emm12 non-scarlet fever isolates, and 18 emm12 strains isolated during 2005-2010 indicated the outbreak was multiclonal. Genome sequencing of 2 nonclonal scarlet fever isolates (HKU16 and HKU30), coupled with diagnostic polymerase chain reaction assays, identified 2 mobile genetic elements distributed across the major lineages: a 64.9-kb integrative and conjugative element encoding tetracycline and macrolide resistance and a 46.4-kb prophage encoding superantigens SSA and SpeC and the DNase Spd1. Phenotypic comparison of HKU16 and HKU30 with the S. pyogenes M1T1 strain 5448 revealed that HKU16 displays increased adherence to HEp-2 human epithelial cells, whereas HKU16, HKU30, and 5448 exhibit equivalent resistance to neutrophils and virulence in a humanized plasminogen murine model. However, in contrast to M1T1, the virulence of HKU16 and HKU30 was not associated with covRS mutation. The multiclonal nature of the emm12 scarlet fever isolates suggests that factors such as mobile genetic elements, environmental factors, and host immune status may have contributed to the 2011 scarlet fever outbreak.
Transfusion | 2003
Ck Lee; Pak-Leung Ho; K.Y. Lee; W.W. Cheng; N.K. Chan; W.C. Tsoi; C. K. Lin
BACKGROUND: The use of bacterial culture to prevent bacterial contamination of blood components has renewed interest for extending the shelf life of PLT concentrates to 7 days after collection.
Vox Sanguinis | 2007
Philip L. H. Yu; K. H. Chung; C. K. Lin; Jennifer S. K. Chan; C. K. Lee
Background and Objectives Adequate blood supply is crucial to the health‐care system. To maintain a stable donor pool, donation‐promotion strategies should not only be targeted in recruitment but also focus on retaining donors to give blood regularly. A study using statistical modelling is conducted to understand the first 4‐year donation patterns for drop‐out and committed first‐time blood donors and to build model for the donor‐type identification based on their first 1·5‐year donation patterns.
Transfusion | 2013
Ck Lee; H.M.H. Chan; Pak-Leung Ho; H.K. Wong; J. N. S. Leung; W.C. Tsoi; C. K. Lin
Risk of transfusion‐transmitted bacterial sepsis has been substantially reduced by a bacterial surveillance program (BST). However, new problems emerge as asymptomatic bacteremia is detected in blood donors. Streptococcus bovis bacteremia, which is known to associate with infective endocarditis and colonic carcinoma, is an example.
Transfusion | 2013
Ck Lee; H.K. Wong; J. Hong; J. N. S. Leung; W.C. Tsoi; C. K. Lin
BACKGROUND: Predonation hemoglobin (PDH) is used to safeguard donors’ welfare, and low hemoglobin (Hb) is known to be the most frequent reason for donor deferral. A study was initiated to assess the PDH and iron status of blood donors in Hong Kong.
Transfusion Medicine | 2012
Ck Lee; H.K. Wong; Pak-Leung Ho; W.C. Tsoi; K.Y. Lee; G.T.F. Tsui; E. Chua; J. N. S. Leung; C. K. Lin
Significant efforts have been made towards bacterial risk minimization by limiting the chance of bacteria entering into collected blood, detecting its presence and eliminating them by pathogen reduction technology. Improved skin disinfection and the use of diversion pouch are effective upstream measures to reduce the risk of bacterial sepsis. Here we report on our experience with the use of blood bags with diversion pouch.
Transfusion Medicine | 2012
H.K. Wong; Ck Lee; J. N. S. Leung; W.C. Tsoi; C. K. Lin
Background: Hepatitis C virus (HCV) infection can result in serious hepatic complications and hence potentially significant burden to the society. Despite advances in technology, transfusion‐transmitted HCV infection still exists. To further minimise the risk, a review on the epidemiology of HCV infection among Chinese blood donors in Hong Kong was conducted.
Transfusion | 2013
H.K. Wong; Ck Lee; J. N. S. Leung; I.Y. Lee; C. K. Lin
There is a paucity of studies on the magnitude of reduction of vasovagal reaction by reduced collection volume. This study was thus conducted to determine the difference in reaction rates between two collection volumes among the young first‐time donors who are at particular risk of reaction.
Vox Sanguinis | 2014
B. K. L. So; C. C. Y. Chu; Pak-Leung Ho; K. H. Chow; J. N. S. Leung; I. Y. M. Lee; C. K. Lin; Ck Lee
Source reduction is important in minimizing bacterial‐contaminated risk of blood products, but previous evaluation of chlorhexidine (CHX) was confounded by inability of Tween and lecithin to neutralize CHX. The study aims to address this limitation and also evaluates the effectiveness of two CHX–alcohol‐based skin disinfectants in blood donation setting.