C. Martin Bailey

Pediatric tracheal homograft reconstruction: A novel approach to complex tracheal stenoses in children

PURPOSE Tracheal stenosis can be a life-threatening problem in children. Long-segment tracheal stenosis and recurrent tracheal stenosis are especially problematic. Tracheal homograft reconstruction represents a novel therapeutic modality for these patients. METHODS Cadaveric trachea is harvested, fixed in formalin, washed in thimerosal (Methiolate), and stored in acetone. The stenosed tracheal segment is opened to widely patent segments proximally and distally. The anterior cartilage is excised and the posterior trachealis muscle or tracheal wall remains. A temporary silicone rubber intraluminal stent is placed and absorbable sutures secure the homograft. Regular postoperative bronchoscopic treatment clears granulation tissue. The stent is removed endoscopically after epithelialization over the homograft. Twenty-four children with severe tracheal stenosis (age 5 months to 18 years, mean +/- standard error of the mean = 8.18 +/- 1.21 years) underwent tracheal homograft reconstruction. All but one had had previous unsuccessful reconstructive attempts. Ten lesions were congenital, nine were posttraumatic, and five were due to prolonged intubation. RESULTS Follow-up ranged from 5 months to 10 years (3.79 +/- 0.70 years). Twenty patients survive (20/24 = 83%), 16 without any airway problems. Four patients are still undergoing treatment. One patient requiring emergency extracorporeal membrane oxygenator support before the operation died 10 days after tracheal homograft reconstruction. Another patient with severe preoperative mediastinal sepsis died 3.5 months after tracheal homograft reconstruction. Two patients with functional airways died late of unrelated problems. CONCLUSIONS Tracheal homograft reconstruction demonstrates encouraging short-term to medium-term results for children with severe recurrent tracheal stenosis. Postoperative bronchoscopic and histologic studies provide evidence of epithelialization and support the expectation of good long-term results.

The changing indications for paediatric tracheostomy

OBJECTIVE To investigate whether the incidence and indications for paediatric tracheostomy in this unit have changed over recent years. METHODS All paediatric tracheostomies performed between 1993 and 2001 were identified from our departmental database. The indications for these were ascertained by retrospective case note review. RESULTS Over the 9-year period studied 362 tracheostomies were performed, the number increased slightly between the first and second half of the period, with peaks in 1997 and 1999. The commonest indication was prolonged ventilation due to neuromuscular or respiratory problems. CONCLUSIONS This large series shows that the increase in frequency of paediatric tracheostomy performed in this unit over the past decade has been due to conditions such as subglottic and tracheal stenosis, respiratory papillomatosis, caustic alkali ingestion and craniofacial syndromes. Conditions in which tracheostomy are now less common are subglottic haemangioma and laryngeal clefts. Prolonged ventilation remains the commonest indication overall.

Surgical Experience With Bone-Anchored Hearing Aids In Children†

Titanium osseointegrated implants for boneanchored hearing aids (BAHAs) have been in use since 1977. A series of 32 children who received implantation since 1990 is reported. The report focuses on the surgical aspects of BAHAs, predisposing factors, and prevention of complications in an unusual pediatric population. The records of 32 children who had undergone two‐stage implantation of a BAHA were retrospectively reviewed. The majority of the patients had craniofacial abnormalities. Of the 32 implantees, 29 use their BAHA at present. Five children failed to achieve osseointe‐gration, and eight patients have had revision surgery for lost abutments, trauma, or chronic skin problems. There were no differences between preimplantation and postimplantation bone or air conduction thresholds. The pediatric BAHA carries with it a unique set of challenges and problems but can be successfully implanted and maintained.

Pediatric airway reconstruction at Great Ormond Street: a ten-year review. I. Laryngotracheoplasty and laryngotracheal reconstruction.

One hundred eight consecutive patients with pediatric laryngotracheal stenosis requiring airway reconstruction over a 10-year period were reviewed. One hundred forty-nine operations consisting of 75 laryngotracheoplasties and 74 laryngotracheal reconstructions with costal cartilage grafting were performed. The Cotton grading scheme of preoperative stenosis was useful in predicting likelihood of decannulation. In all, 90 patients (83%) were decannulated.

Tuberculous laryngitis: a series of 37 patients.

A series of 37 cases of tuberculous laryngitis is reviewed to assess the diagnostic features of the disease.

Current management of choanal atresia

Recent advances in the management of choanal atresia are outlined in the context of our experience at the Hospital for Sick Children, Great Ormond Street, London. Fifty cases were treated over the 6-year period 1982-1988. There was a 72% incidence of other associated congenital anomalies and 30% of patients had the CHARGE association. The advantages and pitfalls of pre-operative computerised axial tomography are illustrated. The surgical results and complications following the trans-nasal approach are discussed. Eighty-four percent of patients had their atresias successfully corrected, 12% restenosed to some extent, and 4% obliterated. The most significant complications were palatal fistulae (8%) and columella ulceration from the Portex tube stents (8%).

A review of the current management of infantile subglottic haemangioma, including a comparison of CO2 laser therapy versus tracheostomy

OBJECTIVES We reassessed the current practice and treatment options used in the management of subglottic haemangiomas (SGHs), including the place for open submucosal surgical excision, and have compared the results of different therapeutic modalities used for SGHs. METHODS The two studies were conducted as separate exercises; (1) a retrospective review of 36 patients collected over a recent 8-year period to assess the current practice and treatment options in use; (2) a retrospective comparative study of a previous cohort of 51 patients with SGHs treated in one of four groups: (a) tracheostomy alone, (b) tracheostomy and CO(2) laser, (c) systemic steroids and CO(2) laser (no tracheostomy) and (d) intralesional steroid injection, CO(2) laser therapy, or both, followed by intubation. RESULTS Systemic steroids were the most commonly used modality of treatment. Resolution of the SGH was achieved in 89% of cases at a mean follow up duration of 34 months. However, tracheostomy was required in 58% of cases, with a mean time from diagnosis to decannulation of 30 months. The time to resolution of SGHs does not appear to be reduced by laser therapy compared with treatment by tracheostomy alone. Intralesional steroid injection or laser therapy together with intubation was associated with avoidance of a tracheostomy in 66% of cases. Single-stage open surgical excision in two cases resulted in successful resolution of the SGH and discharge after a mean follow up period of 3 months. CONCLUSIONS Despite the more widespread use of steroids and other treatment modalities, the requirement for tracheostomy has remained unchanged over the last 20 years. The use of laser therapy does not appear to confer any additional therapeutic benefit over and above tracheostomy alone in bringing about resolution of SGHs. Systemic steroids may reduce the size of the haemangioma but are associated with multiple adverse effects. The decision to use the above techniques must, therefore, be made in the light of these observations. Our early experience of single-stage excision suggests that this technique represents an exciting and promising surgical alternative, and its more widespread adoption may be the only way of further improving the outcome of patients with SGHs.

Fatal and non-fatal food injuries among children (aged 0–14 years)

OBJECTIVE To identify and characterize food items with high risk of airway obstruction in children younger than 15 years. METHODS This retrospective study collected injury data from 1989 to 1998 for 26 pediatric hospitals in the United States and Canada. Aspiration, choking, ingestion, and insertion injuries due to food items were analyzed. The data included 1429 infants and children. Results were compared with fatality data published by the American Association of Pediatrics in 1984. RESULTS The 10 food objects with the highest frequency for both injuries and fatalities were identified. Peanuts caused the highest frequency of injury, and hot dogs were most often associated with fatal outcomes. The severity of respiratory distress prior to hospital evaluation varied for different foods. Age younger than 3 years was the highest-risk factor. Key characteristics such as bite size, shape, and texture were analyzed and found to demonstrate relationships with severity of clinical outcomes. CONCLUSIONS Children younger than 3 years remain at greatest risk of food injury and death. We found that hard, round foods with high elasticity or lubricity properties, or both, pose a significant level of risk. Consideration of the key characteristics of the most hazardous foods may greatly decrease airway obstruction injuries. Food safety education can help pediatricians and parents select, process, and supervise appropriate foods for children younger than 3 years to make them safer for this highest-risk population.

Removal of inhaled foreign bodies—Middle of the night or the next morning?

OBJECTIVE Foreign body inhalation is a potentially life-threatening emergency and is the commonest cause of accidental death in children under one year old. There is varying opinion regarding the urgency for removal of inhaled foreign bodies; most centres in the United Kingdom will take the patient to theatre as soon as can be arranged, regardless of the time of day. At Great Ormond Street Hospital for children it has been standard practice to perform rigid bronchoscopy and removal of an inhaled foreign body on the next available daytime operating list, providing the patient is clinically stable, even if this incurs a delay until the following day. We aimed to identify if any additional morbidity resulted from delaying removal of the foreign body. METHODS Retrospective case note review of all cases of foreign body inhalation seen at our institution over an 11-year period between July 1996 and July 2007. RESULTS 165 patients were referred to our institution with a suspected inhaled foreign body in the study period. 14 patients were managed conservatively due to low clinical suspicion and 57 patients underwent a negative bronchoscopy: these groups were excluded from our analysis. Of the remaining 94 patients, only 7 were taken to theatre outside a scheduled daytime operating list. All of these patients had signs of severe respiratory distress and were operated upon within 4h of their arrival. Of the remaining patients, 41 were taken to theatre on the day of presentation and 46 on the day after presentation; all within normal daytime working hours. No additional post-operative morbidity was identified as a result of our policy to delay bronchoscopy until the next available daytime operating list. CONCLUSIONS It is our perception that delaying removal of suspected inhaled foreign bodies to allow optimal circumstances for manipulation of the paediatric airway is a safe practice at our institution. We have not identified any adverse outcomes related to delaying bronchoscopy to the next available daytime operating list in the clinically stable patient. This remains our preferred method of practice.

The effect of aryepiglottoplasty for laryngomalacia on gastro-oesophageal reflux

OBJECTIVE to investigate whether relief of airway obstruction in laryngomalacia by aryepiglottoplasty affects gastro-oesophageal reflux. METHODS a prospective study of consecutive infants and children with suspected laryngomalacia. Gastro-oesophageal reflux was measured before and after diagnostic microlaryngobronchoscopy and aryepiglottoplasty. RESULTS of the six cases who underwent aryepiglottoplasty and completed the study, three had significant pre-operative reflux according to age. In this group the reflux improved significantly after aryepiglottoplasty. In the other three cases, reflux was not age-significant pre-operatively nor did it change significantly post-operatively. CONCLUSIONS when partial airway obstruction due to laryngomalacia co-exists with gastro-oesophageal reflux, treatment of the airway problem improves respiratory symptoms in all cases and reduces gastro-oesophageal reflux in patients with age-significant reflux. This suggests that there are two clinical groups, those with severe, age-significant reflux, possibly caused by airway obstruction, whose gastro-oesophageal reflux benefits from aryepiglottoplasty; and those whose reflux is physiological and not influenced by aryepiglottoplasty. Therefore aryepiglottoplasty can be expected to reduce gastro-oesophageal reflux in those infants with laryngomalacia who have age-significant reflux.