C. P. Rhoads

Conversion of 1,2,5,6-Dibenzanthracene by Rabbits, Rats, and Mice. Significance in Carcinogenesis of this Conversion

Summary From the extracts of excreta of rabbits, rats, and mice injected with 1,2,5,6-dibenzanthracene, substances of a phenolic nature were isolated which are considered to be conversion products of dibenzanthracene. The substance isolated from injected rabbits was non-carcinogenic and gave absorption bands different from those of the substance obtained from injected rats and mice. This fact suggests that different species metabolize dibenzanthracene differently. The absorption bands of unchanged dibenzanthracene were present in the fraction containing neutral compounds of feces of injected rats, mice, and rarely of rabbits.

Metabolism of Leucocytes in Ringer-Phosphate and in Serum

Summary The rates of respiration and aerobic glycolysis of exudate leucocytes reported by Fleischmann and Kubowitz have been confirmed. A method of measuring the respiration of leucocytes in serum is described. The respiratory rate of leucocytes in serum is greater than the rate in Ringer-phosphate solution.†

Effect of Diet on Susceptibility of Canine Hematopoietic System to Damage by Amidopyrine

Summary and Conclusions The daily administration of 0.5 gm. of amidopyrine causes anemia in dogs fed a diet which causes canine black-tongue. No anemia results when a normal diet is fed. The anemia is associated with a suppression of maturation of hemato-poietic bone marrow cells and it may be prevented and cured by supplementing the diet with autolyzed yeast.

Hemolysin in the Urine in Aplastic Anemia

Summary and Conclusions 1. The urine of patients with aplastic anemia contains no lysin for erythrocytes when tested directly. 2. Lysin appears after hydrolysis at pH 1 and 100°C for 1 hour. 3. Such hydrolysis does not result in the production of lysin in urines which are non-lytic normally.

Effect of Indol on Hematopoiesis in Dogs Fed Deficient Diets

Summary and Conclusion Orally administered indol is causative of anemia in dogs fed a diet which is causative of black tongue. The same amount of indol does not cause considerable anemia in dogs fed a normal diet. Liver extract is preventive and curative of the anemia.