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Featured researches published by C. Tonda-Turo.


Biomedical Materials | 2015

Chitosan membranes for tissue engineering: comparison of different crosslinkers.

Francesca Ruini; C. Tonda-Turo; Valeria Chiono; Gianluca Ciardelli

Chitosan (CS), a derivative of the naturally occurring biopolymer chitin, is an attractive material for biomedical applications thanks to its biocompatibility, biodegradability, antibacterial properties and ability to enhance cell adhesion and growth compared to other biopolymers. However, the physical and mechanical stability of CS based materials in aqueous solutions is limited and crosslinking agents are required to increase CS performances in a biological environment. In this work, the effect of three highly-biocompatible crosslinkers as genipin (GP), γ-glycidoxypropyltrimethoxysilane (GPTMS), dibasic sodium phosphate (DSP) and a combination of GPTMS and DSP (GPTMS_DSP) on CS physicochemical, thermal, morphological, mechanical properties, swelling and degradation behavior was investigated. Infrared spectroscopy and thermogravimetric analyses confirmed the chemical reaction between CS and the different crosslinkers. CS wettability was enhanced when CS was DSP ionically crosslinked showing contact angle values of about 65° and exhibiting a higher swelling behavior compared to covalently crosslinked films. Moreover, all the crosslinking methods analyzed improved the stability of CS in aqueous media, showed model molecule permeation in time and increased the mechanical properties when compared with non-crosslinked films. The possibility to tailor the final properties of CS scaffolds through crosslinking is a key strategy in applying CS in different biomedical and tissue engineering applications. The obtained results reveal that the optimization of the crosslinking mechanism provides CS membrane properties required in different biomedical applications.


Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology | 2018

Combined Influence of Gelatin Fibre Topography and Growth Factors on Cultured Dorsal Root Ganglia Neurons: EFFECTS OF SUBSTRATE AND DRUGS ON DRG NEURONS

Sara Gnavi; Michela Morano; Benedetta Elena Fornasari; Claudio Riccobono; C. Tonda-Turo; Marco Zanetti; Gianluca Ciardelli; Giovanna Gambarotta; Isabelle Perroteau; Stefano Geuna; Stefania Raimondo

Nerve guidance channels facilitate nerve regeneration and represent an attractive alternative to nerve graft. Actually, nano‐ and microstructured biomaterials for nerve reconstruction have gained much attention, thanks to recent discoveries about topography effects on cell behavior and morphology. Electrospun fibres have been proposed as filler or structural component for nerve guidance channels, principally due to their similarity with extracellular matrices which facilitate nerve regeneration. Among several tested biomaterials, gelatin has been used to prepare fibres able to support Schwann cell migration and neurite outgrowth. In this work, the effects of gelatin fibre size on axon elongation and Schwann cell migration have been tested using dorsal root ganglia cultures. Moreover, we analyzed how fibres might affect the expression of specific neuronal subtype markers in sensory neuron cultures and how the combined effect of substrate and biological cues affects neurite growth and gene expression. Data show that fibre topography differentially affects both neurite outgrowth and gene expression and suggest that fibre size and topography associated to specific growth factor exposure might be used to select neuron subpopulations and favor the axonal growth of specific neurons. Anat Rec, 301:1668–1677, 2018.


Archive | 2009

Artificial Scaffolds For Peripheral Nerve Reconstruction

Valeria Chiono; C. Tonda-Turo; Gianluca Ciardelli


6th International Conference Textile and Polymer Biotechnology | 2009

Nanofibrous Scaffolds For Tissue Engineering

C. Tonda-Turo; Valeria Chiono; C. Audisio; Francesca Boccafoschi; Stefano Geuna; Marco Zanetti; Gianluca Ciardelli


Congresso Società Italiana Biomateriali (SIB) | 2016

Nanotechnology-based strategies to treat chronic wounds

C. Tonda-Turo; Monica Boffito; Francesca Ruini; Stefano Calzone; P. Robino; P. Nebbia; Gianluca Ciardelli


Cambridge Clinical Neurosciences Spring School RESTORING FUNCTION; Regeneration, Plasticity, Replacement, Prostheses. | 2016

Natural and synthetic hydrogels in the treatment of neurodegenerative diseases

Valeria Chiono; C. Tonda-Turo; Jack Brelstaff; Monica Boffito; Stefano Calzone; Francesca Ruini; Clara Mattu; Susanna Sartori; Maria Grazia Spillantini; Gianluca Ciardelli


Biomedical Science and Engineering | 2016

Nerve guidance conduits based on bi-layer chitosan membranes for peripheral nerve regeneration

Francesca Ruini; C. Tonda-Turo; Stefania Raimondo; Pierluigi Tos; Pierfrancesco Pugliese; Stefano Geuna; Gianluca Ciardelli


Spring School on Neuroinflammation | 2015

Innovative drug delivery systems for localized release of anti-inflammatory drugs

C. Tonda-Turo; Monica Boffito; Emilia Gioffredi; Valeria Chiono; Stefano Calzone; Susanna Sartori; Gianluca Ciardelli


Congresso di Microchirurgia | 2015

Design of biomimetic nerve guidance channels in peripheral nerve tissue engineering

C. Tonda-Turo; Francesca Ruini; Valeria Chiono; Gianluca Ciardelli


Archive | 2014

Hydrogels as carries for drug delivery

Valeria Chiono; C. Tonda-Turo; Monica Boffito; Susanna Sartori; Emilia Gioffredi; Clara Mattu; Gianluca Ciardelli

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Gianluca Ciardelli

Instituto Politécnico Nacional

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Francesca Boccafoschi

University of Eastern Piedmont

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