C. W. Venables
Newcastle University
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Featured researches published by C. W. Venables.
The Lancet | 1970
Wheldon Ej; C. W. Venables; I. D. A. Johnston
Abstract 255 patients were investigated more than fifteen years after vagotomy and gastroenterostomy. Weight-loss of more than 6 kg. was observed in 32.5% of men and 60% of women. Haemoglobin levels below 90% were found in 43.5% men, and below 80% in 84% women; this anaemia was iron deficient. Metabolic complications seemed to be more common in the women than the men. No radiological evidence of bone disease was seen. 4% had a calcium level below 8.5 mg. per 100 ml. and 6.3% had a raised alkaline-phosphatase level. Pulmonary tuberculosis was found in 7% of patients.
BMJ | 1973
Jack Collin; David Tweedle; C. W. Venables; F. L. Constable; Ivan D. A. Johnston
The Millipore filter unit has been advocated as a means of reducing the chance of bacteria entering the circulation during intravenous infusion. In a prospective study no significant reduction was obtained in the incidence of thrombophlebitis or in the bacterial contamination of cannulae. The unit was inconvenient to use and in-vitro and in-vivo studies showed reduced flow rates and frequent episodes of filter blockage. Its use was further restricted by the fact that blood and fat emulsions would not pass through it.
Digestive Diseases and Sciences | 1975
E L Blair; E R Grund; I. T. Miller; J. D. Reed; D. J. Sanders; M. H. Thompson; C. W. Venables
The histamine H2-receptor antagonist metiamide is an inhibitor of endogenous and stimulated gastric-acid secretion. It appears to have therapeutic possibilities in duodenal-ulcer disease. Three patients exhibiting the Zollinger-Ellison syndrome have been treated with this drug for six months or more. Rapid symptomatic improvement occurred in each case, followed by ulcer healing. There were also reductions in gastric secretion and consistent changes in the fasting serum-gastrin concentration. One patient relapsed temporarily during therapy. There have been no side effects. It is concluded that, in the short term, metiamide is of benefit in the Zollinger-Ellison syndrome.
The Lancet | 1986
S.A Raimes; Wheldon Ej; V Smirniotis; C. W. Venables; I. D. A. Johnston
Truncal vagotomy and drainage is still the commonest operation for duodenal ulcer in the United Kingdom, despite its known association with diarrhoea. The frequency and severity of diarrhoea were compared in 102 randomly selected men 10 or more years after truncal vagotomy and pyloroplasty (TVP) and a control group of 62 men taking long-term maintenance cimetidine treatment 2 or more years after healing of duodenal ulcer. 53% of the TVP group still had diarrhoea attacks compared with only 7% of the cimetidine group (p less than 0.001). Of the TVP patients, 11% had continuous diarrhoea and a further 22% at least one attack a week. 24% were displeased with the change in bowel function, and 8% complained that diarrhoea still seriously affected their lives. This side-effect is unacceptable and truncal vagotomy should now be avoided whenever possible.
Digestive Diseases and Sciences | 1975
M. H. Thompson; J. D. Reed; G. Dale; C. W. Venables
The clinical, endoscopic, and biochemical effects of metiamide, a histamine H2-receptor antagonist, in therapeutic dosage have been studied in a 28-day open trial in patients with duodenal ulcer disease. A good symptomatic response, combined with a 72% ulcer healing rate was observed. There were small but significant rises in plasma creatinine, serum glutamic oxaloacetic transaminase, and serum lactate dehydrogenase during treatment. Small quantities of amino acids appeared in the urine, and the heart size increased slightly. It is concluded that histamine H2-receptor antagonism may be an important therapeutic approach to duodenal ulcer disease.
Digestive Diseases and Sciences | 1976
M. H. Thompson; J. D. Reed; G. Dale; C. W. Venables
To The Editor: It is not surprising that Drs. Butler and Gersh (1) should fail to find any effect of 2 hourly antacids on the healing of gastric ulcers of inpatients. Twenty years ago, Doll and his colleagues (2) had shown that even continuous intragastric neutralization with alkalinized milk drip for 4 weeks had no effect on the rate of healing of gastric ulcers. J.H. BARON, DM, FRCP Department of Surgery Royal Postgraduate Medical School Hammersmith Hospital London W12, England
British Journal of Surgery | 1992
G. L. Carlson; M. Rhodes; S. Stock; R. Lendrum; M. I. Lavelle; C. W. Venables
British Journal of Surgery | 1988
N. R. Parrott; R. M. R. Taylor; C. W. Venables; Christopher O. Record
The Lancet | 1975
M. H. Thompson; C. W. Venables; Miller It; J.D. Reed; Sanders Dj; Grund Er; E.L. Blair
British Journal of Surgery | 1980
M. Slooff; R. Baker; M. I. Lavelle; R. Lendrum; C. W. Venables