Camanni F

[Chromatographic picture of urinary 17-ketosteroids in various forms of hemolymphopathy].

A study on steroid hormone metabolism in 24 cases of blood dyscrasias has been performed through chemical determination of urinary 17-ketosteroids and 17-hydroxycorticosteroids and chromatographic analysis of the former.Corticoids appeared to be preferentially decreased in acute leukemia, chronic myelogenous leukemia and polycythemia, while in chronic lymphatic leukemia and in Waldenstroms disease 17-ketosteroids were affected as well.The chromatographic analysis of 17-ketosteroids showed that fractions IV and V, corresponding to androsterone and etiocholanolone, are decreased in almost all cases. High and bifid peaks III are constantly found in polycythemia and haemophilia; changes of peak III of a minor importance are occasionally found in all types of leukemia.The significance of the data observed is discussed from the point of view of steroid metabolism and a hypothesis is presented to explain the mechanism of the changes occurring in pattern of the various chromatographic fractions of 17-ketosteroids.A study on steroid hormone metabolism in 24 cases of blood dyscrasias has been performed through chemical determination of urinary 17-ketosteroids and 17-hydroxycorticosteroids and chromatographic analysis of the former. Corticoids appeared to be preferentially decreased in acute leukemia, chronic myelogenous leukemia and polycythemia, while in chronic lymphatic leukemia and in Waldenstroms disease 17-ketosteroids were affected as well. The chromat1>graphic analysis 1>f 17-ketosteroids shi>wed that fractfons IV and V, corresponding to androsterone and etiocholanolone, are decreased in almost all cases. High and bifid peaks III are constantly found in polycythemia and haemophilia; changes of peak III of a minor importance are occasionally found in all types of leukemia. The significance of the data observed is discussed from the point of view of steroid metabolism and a hypothesis is presented to explain the mechanism of the changes occurring in pattern of the various chromatographic fractions of 17-ketosteroids.