Camila Downey

Progression of drug exanthemas to serious drug eruptions: A retrospective review identifying early determinants.

Maculo‐papular drug exanthema (MPE) is the most common type of cutaneous adverse drug reaction (CAR). Exanthematous macules and papules may also be the initial presentation of severe CAR (SCAR). We aimed to identify characteristics associated with the diagnosis of SCAR in CAR‐hospitalised patients.

Multifocal spindle cell hemangioma: Report of two cases

In conclusion, our case emphasizes that linear and whorled nevoid hypermelanosis may be dermoscopically heterogeneous, displaying some individual variations. It also confirms that dermoscopy might be useful in differentiating this disorder from its prime differential diagnosis, namely, incontinentia pigmenti, which is characterized by blue-gray dots histologically corresponding to pigmentary incontinence.[3]

Experiencia en loxoscelismo cutáneo y cutáneo visceral de manejo hospitalario: clínica, evolución y propuesta terapéutica

BACKGROUND Loxoscelism is a common pathology in our environment with a broad spectrum of differential diagnoses and presentations, with potentially serious complications, even to the point of death. To date, there is no standard treatment for these patients. AIM To describe the clinical manifestations, main complications, therapeutic management, and evolution of loxoscelism in an inpatient setting from a tertiary hospital in Chile. METHODS All patients consulting and hospitalized in the hospital of the Pontificia Universidad Católica de Chile with diagnosis of loxoscelism between 2014 to 2017 and evaluated by dermatologist were included. Review of clinical files, including symptoms, images, laboratory parameters and treatment. RESULTS We evaluated seventeen inpatient with loxoscelism, whose presentation responds to the national epidemiological pattern. Most cases were managed with antibiotics, systemic corticosteroids, antihistamines, and dapsone. From these, 11.8% corresponded to viscerocutaneous loxoscelism, successfully managed with supportive measures, systemic corticosteroids and antihistamines. Fifty-nine percent healed their cutaneous lesions after one month of treatment, with slight residual scarring or post inflammatory hyperpigmentation, without associated mortality in our series. DISCUSSION Most cases of cutaneous loxoscelism presented excellent response and rapid resolution of the disease after combined therapy with systemic corticosteroids, antibiotics and dapsone, suggesting that the use of these therapies could stop the progression of cutaneous necrosis and prevent complications associated with loxoscelism.

Unusual targetoid nodule on the back.

A 28‐year‐old woman presented with an asymptomatic recurrent nodule on her back for 6 months. The lesion was increasing in size and the patient noted variations in the nodule’s color from pink to light brown. On examination, a non‐tender, red to violaceous nodule with a thin pale brown margin and a peripheral ecchymotic ring measuring 1.6 cm × 1 cm was seen on the right posterior shoulder [Figure 1]. The remainder of the dermatological examination was unremarkable.

[Urticaria pigmentosa: clinical and therapeutic aspects for the paediatrician].

Urticaria pigmentosa, also known as maculopapular mastocytosis, is the most common type of paediatric mastocytosis. It presents with yellow to brown macules or papules, usually located on trunk and extremities. Regarding its diagnostic and therapeutic implications, the objective of this article is to serve as an update for the paediatrician on the most relevant aspects of this pathology.

Tuberculosis en patrón esporotricoide: una presentación inusual de tuberculosis cutánea en un paciente inmunocompetente

Resumen En la actualidad, la tuberculosis sigue siendo un proble -ma de salud publica en el mundo. El compromiso cutaneo es una manifestacion poco frecuente de la infeccion por Mycobacterium tuberculosis . El patron esporotricoide se refiere a la disposicion lineal de los nodulos cutaneos siguiendo el trayecto de los vasos linfaticos, forma de presentacion caracteristica de la esporotricosis, de ahi su nombre. Muy pocos casos han sido reportados sobre tuberculosis cutanea con patron esporotricoide. Se pre-senta el caso clinico de una mujer de 84 anos con nodulos ulcerativos de disposicion lineal en miembro superior causados por Mycobacterium tuberculosis , destacando la importancia de incluir a la tuberculosis cutanea en el diag-nostico diferencial de lesiones con patron esporotricoide. Referencias bibliograficas 1.- World Health Organization. Global Tuberculosis Report 2013. Disponible en: http://apps.who.int/iris/bitstream/10665/91355/1/9789241564656_eng.pd0f. (accedido: 18 de julio de 2014).2.- Ministerio de Salud, Chile. Tuberculosis: Informe de situacion en Chile 2012. Disponible en: http://web.minsal.cl/sites/default/files/files/tuberculosisInforme2012.pdf (accedido: 18 de julio de 2014).3.- Lai-Cheong J E, Perez A, Tang V, Martinez A, Hill V, Menage Hdu P. Cutaneous manifestations of tuberculosis. Clin Exp Dermatol 2007; 32: 461-6.4.- Pau W S, AlSaffar H, Weinstein M, Kitai I. Sporotrichoid-like tuberculosis. Pediatr Infect Dis J 2009; 28: 1135-6.5.- Pandhi D, Reddy B S, Chowdhary S, Khurana N. Cutaneous tuberculosis in Indian children: the importance of screening for involvement of internal organs. J Eur Acad Dermatol Venereol 2004; 18: 546-51.Tuberculosis remains a major global health problem. Cutaneous involvement is a rare manifestation of tuberculosis infection. Sporotrichoid clinical pattern consists of a linear arrangement of nodules along the lymphatic vessels. It is often seen in sporotrichosis. Few cases have been reported of cutaneous tuberculosis presenting as a sporotrichoid clinical pattern. We describe a 84-year-old female with ulcerative nodules on upper extremity caused by Mycobacterium tuberculosis, emphasizing the importance of considering cutaneous tuberculosis in the differential diagnosis of sporotrichoid lesions.