Camila Maria Beder Ribeiro

Human papillomavirus coinfection in the oral cavity of HIV-infected children.

Aim To identify the early presence of human papillomavirus (HPV) DNA in the oral cavity of HIV-infected children. Methods The study group comprised 50 HIV-infected children and 50 healthy aged paired controls. Oral mucosa samples were collected by swab, and a 450 bp HPV DNA fragment was amplified by PCR, using degenerate consensus primers directed to the L1 gene. HPV typing was performed using specifics primers for types 6/16 and 11/18. Results All HPV co-infected children had vertical transmission of HIV. HPV DNA was detected in 6/50 (12.0%) of HIV children and three control group individuals 3/50 (6.0%) (p>0.01). In the HIV group, one had type 11, in the control group one had co-infection of types 11/16, and the others had type 16 and 18. Conclusions Based upon the results, it is concluded that HPV DNA may be present in HIV disease, but no association with immunosuppression, delivery, or medical records (CD4 cell count, viral load and use of highly active antiretroviral therapy) was observed, and no differences could be observed between the groups either.

Dysphagia due to macroglossia in a patient with amyloidosis associated with multiple myeloma: A case report

Amyloidosis is a group of heterogeneous conditions characterized by the deposition of extracellular proteinaceous substances called amyloids. The diagnosis is usually confirmed after a particular body organ has been affected. However, oral manifestations have been identified in 39% of affected patients. Systemic amyloidosis may be primary or in association with multiple myeloma and typically affecting elder adults. The diagnosis of amyloidosis is usually associated with clinical features with histopathological findings, which reveal the presence of acellular eosinophilic deposits. The aim of this report is to describe a clinical case of an elderly patient with dysphagia related to macroglossia and enlargement caused by primary amyloidosis associated with multiple myeloma.

Actinic cheilitis: case report

1 Acadêmica do Curso de Odontologia no Centro Universitário Cesmac. Maceió, ALBrasil. 2 Acadêmica do Curso de Odontologia no Centro Universitário Cesmac. Maceió, ALBrasil. 3 Cirurgiã-Dentista. Doutora em Ciências. Professora titular do Centro Universitário Cesmac. Maceió, ALBrasil. 4 Cirurgiã-Dentista. Mestra em Ensino na Saúde. Professora titular do Centro Universitário Cesmac. Maceió, ALBrasil. 5 Cirurgiã-Dentista. Doutora em Estomatopatologia. Professora titular do Centro Universitário Cesmac. Maceió, ALBrasil.

Caracterização do atraso no diagnóstico do câncer de boca e orofaringe em dois centros de referência

Objectives To analyze the chronology of diagnosis and determine whether clinical and epidemiological variables have an influence on diagnostic delay at two referral centers. Methods The medical records of all patients older than 18 years diagnosed with oral/oropharyngeal cancer from June 2005 to June 2013 were analyzed using SPSS® 20. The association between epidemiological and clinical variables with patient and professional delay was performed using ANOVA, Student’s t-test, and Kruskal-Wallis test. Results In total, 121 medical records were included in the study. Patients were predominantly brown, male, illiterate, living in country towns, smokers, and heavy drinkers (mean age 64.3 years, SD=12.94). The majority (85.1%) of patients were diagnosed at advanced stages of their disease. The greatest delay was patient-related, mean 197.8 days (SD=323.9). Delay in establishing the medical diagnosis averaged 20 days (SD=25.9), and health care system-related delay was 71.1 days (SD=71.7). There was no association of clinical and epidemiological variables with delayed diagnosis (patient and professional). Conclusion Data from the present study suggest that clinical and epidemiological variables do not influence diagnostic delay.