Camilla Pungetti

Current concepts in the biopsy of musculoskeletal tumors: AAOS exhibit selection.

BACKGROUND A musculoskeletal tumor biopsy can involve fine needle aspiration, core needle biopsy, or incisional biopsy. Controversy regarding the diagnostic yield of these biopsy techniques continues. The purpose of this article is to summarize the current concepts in the biopsy of musculoskeletal tumors. METHODS We performed a literature review of clinical articles reporting on the biopsy of bone and soft-tissue primary tumors. Clinical articles were excluded on the basis on abstract content if they represented case reports, review or opinion articles, or technique descriptions. Eighteen of the thirty-nine articles that remained were excluded because the results did not indicate the diagnostic accuracy of the various biopsy techniques. Thus, twenty-one articles with diagnostic data on the biopsy of bone and soft-tissue tumors were included in this review. RESULTS Core needle biopsy appeared to be more accurate than fine needle aspiration, and incisional biopsy appeared to be more accurate than both of these techniques, but the differences did not reach significance. Incisional biopsy was more expensive than the percutaneous biopsy methods. In deep musculoskeletal tumors, incorporation of ultrasonography or computed tomography for guidance is easy and safe and can be useful for increasing the accuracy of the biopsy. Advantages of a percutaneous technique compared with an incisional one are the low risk of contamination and the minimally invasive nature. Certain anatomic locations and histologic types were associated with diagnostic difficulty. Vertebral tumors had the lowest diagnostic accuracy regardless of the biopsy technique. Myxoid, infection, and round cell histologies were associated with the lowest diagnostic accuracy. CONCLUSIONS The current literature has not clarified the optimal biopsy technique for the diagnosis of bone and soft-tissue tumors. However, core needle biopsy is usually preferable to incisional biopsy because of the low risk of contamination and the low cost. In addition, the use of imaging guidance increases the diagnostic accuracy of musculoskeletal biopsies and reduces the risk of complications. If the result of a percutaneous biopsy is nondiagnostic, a small incisional biopsy should be performed. LEVEL OF EVIDENCE Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Surgical Treatment of Cavus Foot in Charcot-Marie-Tooth Disease: A Review of Twenty-four Cases

Charcot-Marie-Tooth disease is the single most common diagnosis associated with cavus foot. The imbalance involving intrinsic and extrinsic muscles has been suggested as the main pathogenetic cause of cavus foot in this disease. The goal of surgical treatment is to correct the deformity to obtain a plantigrade foot. In the presence of a flexible deformity and the absence of degenerative arthritis, preserving as much as possible of the overall range of motion of the foot and ankle is advisable. Twenty-four cavus feet in twelve patients with Charcot-Marie-Tooth disease were included in the study. Clinical evaluation was summarized with the Maryland Foot Score. Radiographic evaluation assessed calcaneal pitch, Meary angle, Hibb angle, and absence of degenerative joint changes. Only patients who had a flexible deformity, with varus of the heel reducible in the Coleman-Andreasi test, and did not have degenerative joint arthritis were included in this study. Surgical treatment consisted in plantar fasciotomy, midtarsal osteotomy, extensor hallucis longus tendon transfer to the first metatarsal (Jones procedure), and dorsiflexion osteotomy of the first metatarsal. Mean follow-up was six years (range, two to thirteen years). The mean Maryland Foot Score was 72 preoperatively and 86 postoperatively. The postoperative result was rated as excellent in twelve feet (50%), good in ten (42%), and fair in two (8%). Mean calcaneal pitch was 34° preoperatively and 24° at the time of the latest follow-up, the mean Hibb angle was 121° preoperatively and 136° postoperatively, and the mean Meary angle was 25° preoperatively and 2° postoperatively. Plantar fasciotomy, midtarsal osteotomy, the Jones procedure, and dorsiflexion osteotomy of the first metatarsal yielded adequate correction of flexible cavus feet in patients with Charcot-Marie-Tooth disease in the absence of fixed hindfoot deformity. The fact that the improvement in the outcome score was only modest may be attributable to the lack of motor balance.

Proximal humeral fractures in elderly patients

Proximal humeral fractures are common in the setting of osteoporosis and they represent a problem not only for increased mortality risk factors, but also in terms of costs and management. Their increased incidence has resulted in an evolution of treatment options, but currently there is no scientific evidence that defines the best treatment to choose. The choice of treatment depends on a variety of factors, such as fracture dislocation, fracture classification, bone quality, patient’s age, functional requirements and general medical conditions. The debate about the treatment is still open, both for the decision between surgical and conservative treatment, and between different types of surgical techniques; nowadays it remains unclear whether surgery will produce better outcomes in function and quality of life in elderly osteoporotic patients.

Ankle and foot: Chronic instability

Ankle sprain is a common sports-related injury that predominantly occurs in skeletally mature patients with a lower incidence in children and adolescents. Recurrence of acute twisting episodes may lead to chronic ankle instability, which is distinguished into mechanical and functional. Mechanical ankle instability (MAI) is characterized by an abnormal ankle mobility, assessed clinically using manual stress application via the anterior drawer and the talar tilt tests. Functional ankle instability (FAI) was firstly described as a subjective feeling of the ankle giving way during either physical activity or during common activities of daily living. More than 80 different surgical procedures have been described in literature for managing chronic ankle instability. Anatomic reconstruction should be the primary choice for the surgical treatment of chronic ankle instability in young patient and more widely in athletes. Some studies are available addressing non-anatomic reconstruction in youngers and reporting satisfactory results, even if the need of bony tunnels in a growing epiphysis, alteration in ankle biomechanics and the high frequency of restricted subtalar motion are major drawbacks of non-anatomic reconstruction.