Canan Gündüz

Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database: Obstructive sleep apnoea and dyslipidaemia

Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort.

Prevalence of overlap syndrome in chronic obstructive pulmonary disease patients without sleep apnea symptoms

The co‐existence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is a common phenomenon referred to as overlap syndrome (OS). In this study, we evaluated the prevalence of OS in mild hypoxemic COPD patients without OSA symptoms and compared characteristics of OS and COPD patients.

Factors affecting treatment success in community-acquired pneumonia.

BACKGROUND/AIM Treatment failure in hospitalized patients with community-acquired pneumonia is a major cause of mortality. The aim of this study was to evaluate the factors affecting treatment success in community-acquired pneumonia. MATERIALS AND METHODS A total of 537 patients (mean age: 66.1 ± 15.8 years, 365 males) registered to the Turkish Thoracic Society Pneumonia Database were analyzed. Of these, clinical improvement or cure, defined as treatment success, was achieved in 477, whereas 60 patients had treatment failure and/or died. RESULTS Lower numbers of neutrophils (5989.9 ± 6237.3 vs. 8495.6 ± 7279.5/mm3), higher blood urea levels (66.1 ± 42.1 vs. 51.2 ± 38.2 mg/dL), higher Pneumonia Severity Index (PSI) scores (123.3 ± 42.6 vs. 96.3 ± 32.9), higher CURB-65 scores (2.7 ± 1.2 vs. 2.2 ± 0.9), lower PaO2/FiO2 ratios (216.3 ± 86.8 vs. 269.9 ± 65.6), and the presence of multilobar (33.3% vs. 16.4%) and bilateral (41.7% vs. 18.9%) radiologic infiltrates were related to treatment failure. The PSI score and PaO2/FiO2 ratio were independent parameters affecting treatment results in multivariate linear regression analysis (P < 0.001). CONCLUSION The risk of treatment failure is high in patients with severe pneumonia and with respiratory failure. Effective treatment and close monitoring are required for these cases.

Serum procalcitonin and C-reactive protein kinetics as indicators of treatmentoutcome in hospitalized patients with community-acquired pneumonia.

BACKGROUND/AIM There has been growing interest in the use of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with community-acquired pneumonia (CAP). The aim of this study was to investigate whether an assessment of fever, leukocyte count, and serum CRP and PCT levels on admission and during follow-up (day 3) provides any information about the clinical outcome in hospitalized patients with CAP. MATERIALS AND METHODS Patients with a diagnosis of CAP who were admitted to and followed at four university hospitals were evaluated retrospectively using the Turkish Thoracic Society Pneumonia Database. RESULTS A total of 103 hospitalized CAP patients (57 males, mean age: 61.5 ± 16.7 years) were enrolled in the study. Treatment failure (TF) was observed in 20 patients (19.4%). Pneumonia Severity Index scores, serum CRP levels, and PCT levels on admission were significantly higher in the TF group. There were significant decreases in CRP and PCT levels between admission day and day 3 in the treatment success group. CONCLUSION In patients with CAP, the body temperature and leukocyte count on admission do not predict outcome. Monitoring levels of CRP and PCT may be useful as a predictor of treatment outcome.

The prevalence of influenza vaccination among elderly attending to a chest disease outpatient clinic and associated factors with vaccination

Influenza has such a huge impact that it is estimated to be the infectious cause with the greatest morbidity and mortality in the world. Elderly are more vulnerable individuals for increased influenza-related complications and deaths. Vaccination prevents pneumonia, hospitalization and reduces deaths from influenza, pneumonia and all causes.Although vaccination is recommended for elderly, prevalance is low in Turkey. The prevalance in a community-based study group is reported 15 %, where as the prevalances in clinic- based studies in COPD patients are reported as 34-37 %. Female elderly vaccination prevalence is higher than males in healthy groups while it is lower in COPD patients. Primary objective is to determine the prevalance of influenza vaccination in elderly. Secondary objectives includes determining the factors associated with vaccination in elderly such as sociodemographic factors (age, gender, education level), comorbidities smoking history and vaccine recommendation by healthcare professional. Our study has begun in December 2015. By June 2016, 616 patient is planning to be included. our pilot study includes 141 patients. 62,4 % (n=88) was male. Median age was 72,75 (65-91).75,2% of the patients were informed about the vaccine before and 19.1% of the patients had the vaccine. Main reason for not getting vaccinated was not heard of vaccine before (26.2%) , don9t need vaccination (18.4%) , forgot the time period for vaccination (8.5%). Only 29.1% of healthcare professional recommended seasonal flu vaccine.