Candan Cengiz

Plasma interleukin-1α, interleukin-1β and interleukin-1 receptor antagonist levels in pre-eclampsia

Abstract The values of plasma interleukin-1α (IL-1α), interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1ra) levels were evaluated as the markers of pre-eclampsia in 35 serial plasma samples from ten pregnant women who subsequently developed pre-eclampsia and in 74 plasma samples from 20 uncomplicated pregnancies, retrospectively. No correlation was found between plasma IL-1α, IL-1β and IL-1ra levels, liver and renal function tests. thrombocyte and white blood cell counts, proteinuria, systolic and diastolic blood pressures and gestational weeks. Almost equal levels of IL-1α and IL-1β were measured in all corresponding groups, but these were too few in number to statistically analyze. IL-1ra values were higher in the pre-eclampsia group than in the uncomplicated pregnancy group, at 20–25 and 31–35 gestational weeks significantly and 26–30 gestational weeks insignificantly and showed an increase during labor in both groups. It was found to have 58% positive predictivity, 100% negative predictivity, 50% specificity and 100% sensitivity at gestational weeks 20–25. According to these results, IL-1ra seems to be considered for its high negative predictivity in the exclusion of the probability of pre-eclampsia development during antenatal visits, but its plasma level is not correlated with the severity of the disease.

Plasma anti-oxidant status and lipid profile in non-gravida women with a history of pre-eclampsia

Objective:  To investigate the total plasma anti‐oxidant status, the plasma lipid profile and the uterine artery Doppler velocity waveform in formerly pre‐eclamptic women.

The role of plasma renin activity in distinguishing patients with polycystic ovary syndrome (PCOS) from oligomenorrheic patients without PCOS

All the components of the renin-angiotensin system have been identified in the human ovary. Renin plays a major role in folliculogenesis, and possibly in follicular atresia. Polycystic ovary syndrome (PCOS) is characterized by early follicular atresia. We studied whether assessment of plasma renin activity would be useful for diagnosing PCOS and distinguishing PCOS and non-PCOS in oligomenorrheic patients. Patients were divided into three groups: PCOS group (group 1, n = 40), non-PCOS oligomenorrheic group (group 2, n = 30) and ovulatory control group (group 3, n = 30). Plasma renin activity was determined in the early follicular phase of the menstrual cycle. Baseline serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, insulin, aldosterone and androgens (total testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate and 17α hydroxyprogesterone) were determined in all groups. The mean LH level was lower (4.94 ± 4.65 mIU/ml) in control patients than in PCOS patients (12.9 ± 1.75 mIU/ml) and non-PCOS oligomenorrheic patients (10.8 ± 1.65 mIU/ml). There was no statistically significant difference between the groups regarding FSH levels. The mean plasma renin activity was 3.47 ± 0.29 ng/ml in the PCOS group. The mean plasma renin activity was 1.59 ± 0.21 ng/ml the non-PCOS oligomenorrheic group (statistically significiant differrence). There was no statistically significant difference between the non-PCOS oligomenorrheic (1.59 ± 0.21 ng/ml) and control groups (1.2 ± 0.16 ng/ml). Use of plasma renin activity alone as a diagnostic marker in PCOS is not useful, because the clinical findings of PCOS are heterogeneous and the pathogenesis is unclear. However, it can be used together with other variables to diagnose women with PCOS and to distinguish non-PCOS oligomenorrheic women from those with PCOS.

Anticardiolipin antibodies in pregnancy induced hypertension

It was suggested that anticardiolipin antibodies (ACA) were found positive in some obstetrical problems such as recurrent foetal losses, intrauterine growth retardation, etc. The aim of this study was to determine ACA levels in pregnancy induced hypertension (PIH) cases. ACA IgG and IgM levels were measured by the ELISA method in 65 PIH cases and 23 control pregnancies. We could not find any difference between the PIH and the control groups. There was not any statistically significant difference between the subtypes of PIH. According to these results, we say that ACA IgG and IgM levels have no diagnostic and prognostic value in PIH.

Androgens and sexual dysfunction in naturally and surgically menopausal women

Aim:  To evaluate the influence of surgical versus natural menopause on sexual dysfunction, and the role of androgens in that context.

Fetal İntrakraniyal Teratomun Erken Prenatal Tanısı ve Fetal İntrakraniyal Kitlelere Yaklaşım

OZET Konjenital intrakraniyal tumorler, oldukca nadir gorulen cocukluk cagi santral sinir sistemi tumorleridir. Bu tumorlerin onemli bir kismini teratomlar olusturmaktadir. Intrakraniyal teratomlarin prognozlari kotudur. Prenatal tani konulabilen olgularin sag kalim ve canli dogum oranlari oldukca dusuktur. Obstetrik ultrasonografi oncelikli tani yontemidir; bununla birlikte secilmis vakalarda, manyetik rezonans goruntuleme (MRG) taniya yardimci olabilir. MRG, tumorun fetal beyinde yol actigi hasarin ortaya konmasinda ve gebeligin prognozunun belirlenmesinde faydali olabilir. Bu yazida, 22. gebelik haftasinda tanisi konulan fetal beyin teratomu vakasi sunulmustur. Bilgimize gore, bu olgu, literaturde yayinlanan 14. gebelik haftasinda tani almis olan intrakraniyal teratom olgusundan sonra en erken tani alan ikinci intrakraniyal teratom olgusudur. Ultrasonografi ile fetal kraniyum icerisinde, heterojen eko sergileyen, duzgun sinirli, yer kaplayan kitle ile birlikte sekonder obstruktif hidrosefali saptanmistir. Olgunun MRG ile elde edilen bulgulari bu acidan ultrasonografik bulgular ile benzerlik gostermistir. Gebelik ailenin de onayi alinarak termine edilmistir. Sunulan olguda MRG taniya ve olgunun yonetimine ek katki saglayamamistir. Bu sunumda, olgunun sonografi ve MRG bulgulari ile birlikte bu vakalara obstetrik yaklasim tartisilmaktadir.