Candido Gude
Merck & Co.
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Publication
Featured researches published by Candido Gude.
Bioorganic & Medicinal Chemistry Letters | 2014
Timothy A. Blizzard; Helen Chen; Seongkon Kim; Jane Y. Wu; Rena Bodner; Candido Gude; Jason E. Imbriglio; Katherine Young; Young-Whan Park; Aimie M. Ogawa; Susan L. Raghoobar; Nichelle Hairston; Ronald E. Painter; Doug Wisniewski; Giovanna Scapin; Paula M. D. Fitzgerald; Nandini Sharma; Jun Lu; Sookhee Ha; Jeff Hermes; Milton L. Hammond
β-Lactamase inhibitors with a bicyclic urea core and a variety of heterocyclic side chains were prepared and evaluated as potential partners for combination with imipenem to overcome class A and C β-lactamase mediated antibiotic resistance. The piperidine analog 3 (MK-7655) inhibited both class A and C β-lactamases in vitro. It effectively restored imipenems activity against imipenem-resistant Pseudomonas and Klebsiella strains at clinically achievable concentrations. A combination of MK-7655 and Primaxin® is currently in phase II clinical trials for the treatment of Gram-negative bacterial infections.
Giornale italiano di chemioterapia | 2014
Timothy A. Blizzard; Helen Chen; Candido Gude; Jeffrey D. Hermes; Jason E. Imbriglio; Seongkon Kim; Jane Y. Wu; Sookhee Ha; Christopher J. Mortko; Ian Mangion; Nelo R. Rivera; Rebecca T. Ruck; Michael Shevlin
Bioorganic & Medicinal Chemistry Letters | 2004
Timothy A. Blizzard; Frank P. DiNinno; Jerry D. Morgan; Helen Chen; Jane Y. Wu; Candido Gude; Seongkon Kim; Wanda Chan; Elizabeth T. Birzin; Yi Tien Yang; Lee-Yuh Pai; Zhoupeng Zhang; Edward C. Hayes; Carolyn DaSilva; Wei Tang; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond
Bioorganic & Medicinal Chemistry Letters | 2006
Timothy A. Blizzard; Candido Gude; Jerry D. Morgan; Wanda Chan; Elizabeth T. Birzin; Marina Mojena; Consuelo Tudela; Fang Chen; Kristin Knecht; Qin Su; Bryan Kraker; Ralph T. Mosley; Mark A. Holmes; Nandini Sharma; Paula M. D. Fitzgerald; Susan P. Rohrer; Milton L. Hammond
Bioorganic & Medicinal Chemistry Letters | 2007
Timothy A. Blizzard; Candido Gude; Wanda Chan; Elizabeth T. Birzin; Marina Mojena; Consuelo Tudela; Fang Chen; Kristin Knecht; Qin Su; Bryan Kraker; Mark A. Holmes; Susan P. Rohrer; Milton L. Hammond
Bioorganic & Medicinal Chemistry Letters | 2007
Timothy A. Blizzard; Candido Gude; Jerry D. Morgan; Wanda Chan; Elizabeth T. Birzin; Marina Mojena; Consuelo Tudela; Fang Chen; Kristin Knecht; Qin Su; Bryan Kraker; Ralph T. Mosley; Mark A. Holmes; Susan P. Rohrer; Milton L. Hammond
Archive | 2009
Timothy A. Blizzard; Helen Chen; Candido Gude; Jeffrey D. Hermes; Jason E. Imbriglio; Seongkon Kim; Jane Y. Wu; Christopher J. Mortko; Ian Mangion; Nelo R. Rivera; Rebecca T. Ruck; Michael Shevlin
Archive | 2017
Alexander Pasternak; Barbara Pio; Candido Gude; Dooseop Kim; Fa-Xiang Ding; Haifeng Tang; Harry R. Chobanian; Jinlong Jiang; Reynalda K. de Jesus; Shaw Walsh; Shuzhi Dong; Timothy A. Blizzard
Archive | 2015
Richard A. Berger; Timothy A. Blizzard; Brian Campbell; Helen Chen; John S. Debenham; Sunita V. Dewnani; Byron DuBois; Candido Gude; Zack Zhiqiang Guo; Bart Harper; Zhiyong Hu; Songnian Lin; Ping Liu; Ming Wang; Feroze Ujjainwalla; Jiayi Xu; Libo Xu; Rui Zhang
Archive | 2015
William K. Hagmann; Bing Li; Jason W. Szewczyk; Bowei Wang; Dann L. Parker; Timothy A. Blizzard; Hubert Josien; Purakkattle Biju; Harry R. Chobanian; Candido Gude; Ravi P. Nargund; Barbara Pio; Qun Dang; Linus S. Lin; Bin Hu; Mingxiang Cui; Zhengxia Chen; Meibi Dai; Zaihong Zhang; Ying Lv; Lili Tian
