Canute Vaz

Quantifying short-lived events in multistate ionic current measurements.

We developed a generalized technique to characterize polymer–nanopore interactions via single channel ionic current measurements. Physical interactions between analytes, such as DNA, proteins, or synthetic polymers, and a nanopore cause multiple discrete states in the current. We modeled the transitions of the current to individual states with an equivalent electrical circuit, which allowed us to describe the system response. This enabled the estimation of short-lived states that are presently not characterized by existing analysis techniques. Our approach considerably improves the range and resolution of single-molecule characterization with nanopores. For example, we characterized the residence times of synthetic polymers that are three times shorter than those estimated with existing algorithms. Because the molecule’s residence time follows an exponential distribution, we recover nearly 20-fold more events per unit time that can be used for analysis. Furthermore, the measurement range was extended from 11 monomers to as few as 8. Finally, we applied this technique to recover a known sequence of single-stranded DNA from previously published ion channel recordings, identifying discrete current states with subpicoampere resolution.

0.5 V Supply Voltage Operation of In 0.65 Ga 0.35 As/GaAs 0.4 Sb 0.6 Tunnel FET

In this letter, we demonstrate using fast current-voltage measurements, low switching slope of 64 mV/decade over a drain current range between

Electron spin resonance scanning probe spectroscopy for ultrasensitive biochemical studies.

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PBTI-Induced Random Timing Jitter in Circuit-Speed Random Logic

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Accurate RRAM transient currents during forming

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Device-level PBTI-induced timing jitter increase in circuit-speed random logic operation

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Correction to Quantifying Short-Lived Events in Multistate Ionic Channel Measurements.

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Observation of strong reflection of electron waves exiting a ballistic channel at low energy

m in staggered-gap In0.65Ga0.35As/GaAs0.4Sb0.6 tunneling field-effect transistors (TFETs) at

Impact of BTI on random logic circuit critical timing

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MOSAIC: A Modular Single-Molecule Analysis Interface for Decoding Multistate Nanopore Data

V. This is achieved through a combination of low damage mesa sidewall etch and improvement in electrical quality of the high-