Carina Chi Wai Chan

A prospective randomised comparison of sublingual and vaginal misoprostol in second trimester termination of pregnancy.

Objective  To compare the efficacy, side effects and acceptability of sublingual and vaginal misoprostol for second trimester medical abortion.

Ovarian stromal vascularity is not predictive of ovarian response and pregnancy

The role of ovarian stromal vascularity in the prediction of the ovarian response and pregnancy in infertile women was evaluated by comparing age of women, body mass index (BMI), basal FSH concentration, antral follicle count (AFC) and ovarian stromal vascularity indices measured by three-dimensional power Doppler ultrasound. A total of 111 women in their first IVF cycle were analysed. They were aged <40 years with basal FSH concentration <10 IU/l on recruitment for IVF treatment. AFC, mean ovarian volume and mean ovarian 3D power Doppler flow indices were determined on day 2 of the treatment cycle prior to a standard regimen of ovarian stimulation. Ovarian response was represented by the number of oocytes, serum oestradiol, the duration and dosage of gonadotrophins. AFC achieved the best predictive value in relation to the number of oocytes obtained, followed by age of women and BMI. Basal FSH concentration was the only predictive factor for the duration and dosage of gonadotrophin used. Mean ovarian 3D power Doppler flow indices were not predictive of pregnancy in a multiple logistic regression analysis. Ovarian 3D power Doppler flow indices measured after pituitary down-regulation were not predictive of the ovarian response and pregnancy in the IVF treatment.

Changes in endometrial and subendometrial blood flow in IVF

A good blood supply to the endometrium is usually considered as an essential requirement for implantation. Endometrial and subendometrial blood flow was evaluated on the days of human chorionic gonadotrophin (HCG) administration and embryo transfer and the percentage change in endometrial and subendometrial blood flow between these 2 days was assessed as a predictor of pregnancy during IVF treatment. A three-dimensional (3D) ultrasound examination with power Doppler was performed in 293 patients undergoing the first IVF cycle to determine endometrial thickness, endometrial volume, vascularization index, flow index and vascularization flow index of endometrial and subendometrial regions on the days of HCG and embryo transfer. Patients in non-pregnant and pregnant groups had comparable endometrial thickness, endometrial volume and 3D power Doppler flow indices of endometrial and subendometrial regions measured on either day. Percentage changes in endometrial and subendometrial 3D power Doppler flow indices were also similar. In conclusion, endometrial and subendometrial blood flow on the days of HCG and embryo transfer and the percentage change in endometrial and subendometrial blood flows between these 2 days were not predictive of pregnancy in IVF treatment.

Sequential use of letrozole and gonadotrophin in women with poor ovarian reserve: a randomized controlled trial

Sequential use of letrozole and human menopausal gonadotrophin (HMG) was compared with HMG only in poor ovarian responders undergoing IVF. Patients (n=53) with less than four oocytes retrieved in previous IVF cycles or less than five antral follicles were randomized to either letrozole for 5days followed by HMG or HMG alone. The letrozole group had lower dosage of HMG (P<0.001), shorter duration of HMG (P<0.001) and fewer oocytes (P=0.001) when compared with controls. Live-birth rate was comparable with a lower miscarriage rate in the letrozole group (P=0.038). Serum FSH concentrations were comparable in both groups except on day 8, while oestradiol concentrations were all lower in the letrozole group from day 4 (all P<0.001). Follicular fluid concentrations of testosterone, androstenedione, FSH and anti-Müllerian hormone were higher in the letrozole group (P=0.009, P=0.001, P=0.046 and P=0.034, respectively). Compared with HMG alone, sequential use of letrozole and HMG in poor responders resulted in significantly lower total dosage and shorter duration of HMG, a comparable live-birth rate, a significantly lower miscarriage rate and a more favourable hormonal environment of follicular fluid. The management of poor ovarian responders or women with poor ovarian reserve in IVF is controversial. The use of letrozole has been studied; however, results are inconsistent. This randomized trial studied the sequential use of letrozole and gonadotrophin compared with gonadotrophin alone in poor responders undergoing IVF. The sequential use of letrozole and gonadotrophin led to a significantly lower dosage and shorter duration of gonadotrophin use, significantly fewer oocytes, comparable live-birth rate, a significantly lower miscarriage rate and a more favourable hormonal environment at a lower cost.

Comparison of 2-dimensional, 3-dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles

We compared the ultrasonographic parameters for endometrial receptivity between 2 consecutive in vitro fertilization (IVF) cycles in the same patients.

The impact of stakeholders and mobile phone use on educational achievement in Ghana: A humanitarian work psychology study

Entrenched in human resources, leadership development and Fortune 500 selection systems, industrial and organizational (I-O) psychology is the study of human psychology in the workplace. I-O psychologists employ an empirical approach to selection, training and performance management in order to improve the profitability and overall success of organizations. I-O psychology has not classically been known for a focus on the humanitarian pursuits and organizations of the world. However, recent years have seen the growth of humanitarian work psychology (HWP) as a subfield of I-O, focused on translating research and application of traditional I-O principles to improving human welfare. With this increased interest in the ability and responsibility of I-O psychologists to contribute to the “greater good” has come a strong call for more information and research on effective methods of transferring I-O across humanitarian contexts. This book is among a growing number of publications taking steps to address the poverty of concrete scholarly literature addressing HWP concerns, but is unique in its approach to and organization of the subject matter. The book is broadly targeted to researchers and practitioners who work within the social sciences (e.g., psychology, BOOK REVIEW

Ovarian stromal blood flow following clomiphene citrate challenge test in infertile women.

To compare ovarian stromal blood flow indices in the follicular phase and after clomiphene citrate (CC) in infertile women.