Carine Baraguey

Curcacycline B, a cyclic nonapeptide from Jatropha curcas enhancing rotamase activity of cyclophilin

The structure of curcacycline B (1), a cyclic nonapeptide isolated from Jatropha curcas latex was elucidated by combination of chemical degradation, LSIMS data and 2D NMR experiments. Curcacycline B was shown to enhance the rotamase activity of human cyclophilin B.

Pohlianins A, B and C, cyclic peptides from the laxes of Jatropha pohliana ssp. molissima

Abstract From the EtOAc extract of the latex of Jatropha pohliana (Euphorbiaceae), two cyclic heptapeptides, pohlianins A (1) and B (2) and one cyclic octapeptide, pohlianin C (3) were isolated by a multi-step chromatography procedure, including HPLC. Their structure were elucidated by chemical degradation, mass spectrometry, homonuclear and heteronuclear NMR experiments. Conformational analysis of these peptides was made by using NMR experiments and distance geometry calculations. Their antimalarial activities were examined.

Mahafacyclin A, a cyclic heptapeptide from Jatropha mahafalensis exhibiting β-bulge conformation

Abstract The structure of mahafacyclin A ( 1 ), a cyclic heptapeptide isolated from Jatropha mahafalensis latex was elucidated by a combination of chemical degradation, LSIMS data and 2D NMR experiments. Mahafacyclin A solution conformation was shown to have β-bulge characteristics.

Isolation, structure and synthesis of mahafacyclin B, a cyclic heptapeptide from the latex of Jatropha mahafalensis

Mahafacyclin B is a cyclic heptapeptide with antimalarial activity isolated from the latex of Jatropha mahafalensis. The structure is elucidated by chemical degradation, tandem mass spectrometry, homo- and heteronuclear NMR experiments, and confirmed by synthesis.

Borononucleotides: synthesis, and formation of a new reversible boronate internucleosidic linkage

The synthesis of a borononucleotide analogue of thymidine and its association towards the formation of new borono-linked dimers is described.

Isolation, structure and synthesis of chevalierins A, B and C, cyclic peptides from the latex of Jatropha chevalieri

From the EtOAc extract of the latex of Jatropha chevalieri (Euphorbiaceae), two cyclooctapeptides, chevalierins A (1) and B (2), and a cyclononapeptide, chevalierin C (3), were isolated by a multi-step chromatography procedure, including HPLC. Their structures were elucidated by chemical degradation, mass spectrometry, homonuclear and heteronuclear NMR experiments and confirmed from their synthesis. Their antimalarial activities were examined.

Synthesis of a new internucleosidic linkage: the Borononucleotides

The synthesis of a borononucleotide analogue of thymidine and its association with various nucleosides, nucleotides and saccharides is described.