Carl Nath

Can sulfasalazine prevent infection-mediated pre-term birth in a murine model?

Citation Nath CA, Ananth CV, Smulian JC, Peltier MR. Can sulfasalazine prevent infection‐mediated pre‐term birth in a murine model? Am J Reprod Immunol 2010; 63: 144–149

ORIGINAL ARTICLE: Can Sulfasalazine Prevent Infection-Mediated Pre-Term Birth in a Murine Model?

Citation Nath CA, Ananth CV, Smulian JC, Peltier MR. Can sulfasalazine prevent infection‐mediated pre‐term birth in a murine model? Am J Reprod Immunol 2010; 63: 144–149

The Normal anticoagulant system and risk of placental abruption: protein C, protein S and resistance to activated protein C

Objective. To examine the association between maternal thrombophilia associated with anticoagulation (proteins C and S and activated protein C resistance ratio, APCR) and risk of placental abruption. Methods. Data were derived from a case–control study – The New Jersey-Placental Abruption Study (2002–2007). Maternal blood was collected from abruption cases and controls and was assayed for the thrombophilias. Decreased protein C, S and APCR was defined as values <5% and <10% among controls. Results. Of a total of 132 cases and 127 controls, 3 were heterozygous for the factor V Leiden mutation (1 case and 2 controls). Mean (± standard deviation) protein C (114.2 ± 25.6 vs. 121.4 ± 27.6; P = 0.009), protein S (39.9 ± 18.4 vs. 35.7 ± 15.2; P = 0.043) and APCR (2.86 ± 0.29 vs. 2.88 ± 0.27; P = 0.039) were different between cases and controls. Abruption cases were associated with an odds ratio of 3.2 (95% CI 1.2, 9.9) in relation to decreased protein C (<Fifth centile). Decreases in both protein S and APCR ratio were not associated with abruption. Conclusions. A decrease in protein C was associated with an increased risk for abruption, suggesting an important role for the physiologic anticoagulant system in the etiology of placental abruption.

Successful conservative management of hereditary hemorrhagic telangiectasia in pregnancy. A case report.

Background: Hereditary hemorrhagic telangiectasia (HHT) is a condition characterized by multiple telangiectases and arteriovenous malformations. Women with HHT may develop life-threatening complications in pregnancy. In particular, death from pulmonary hemorrhage has been reported. Consequently, these women are often advised not to conceive or to terminate their pregnancies. Case: We report a case of conservative management of HHT in pregnancy with a good outcome. Conclusion: This case demonstrates that in carefully selected cases, women with HHT who are managed conservatively may have good pregnancy outcomes. A diagnosis of HHT alone is not reason to advise women against pregnancy, nor should these women routinely be advised to undergo pregnancy termination.

ORIGINAL ARTICLE: Can Sulfasalazine Prevent Infection-Mediated Pre-Term Birth in a Murine Model?: SULFASALAZINE AND PRE-TERM BIRTH

Citation Nath CA, Ananth CV, Smulian JC, Peltier MR. Can sulfasalazine prevent infection‐mediated pre‐term birth in a murine model? Am J Reprod Immunol 2010; 63: 144–149