Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Carl R. Schmidt is active.

Publication


Featured researches published by Carl R. Schmidt.


Gastroenterology | 2010

Experimentally Derived Metastasis Gene Expression Profile Predicts Recurrence and Death in Patients With Colon Cancer

J. Joshua Smith; Natasha G. Deane; Fei Wu; Nipun B. Merchant; Bing Zhang; Aixiang Jiang; Pengcheng Lu; J. Chad Johnson; Carl R. Schmidt; Christina E. Bailey; Steven Eschrich; Christian Kis; Shawn Levy; M. Kay Washington; Martin J. Heslin; Robert J. Coffey; Timothy J. Yeatman; Yu Shyr; R. Daniel Beauchamp

BACKGROUND & AIMS Staging inadequately predicts metastatic risk in patients with colon cancer. We used a gene expression profile derived from invasive, murine colon cancer cells that were highly metastatic in an immunocompetent mouse model to identify patients with colon cancer at risk of recurrence. METHODS This phase 1, exploratory biomarker study used 55 patients with colorectal cancer from Vanderbilt Medical Center (VMC) as the training dataset and 177 patients from the Moffitt Cancer Center as the independent dataset. The metastasis-associated gene expression profile developed from the mouse model was refined with comparative functional genomics in the VMC gene expression profiles to identify a 34-gene classifier associated with high risk of metastasis and death from colon cancer. A metastasis score derived from the biologically based classifier was tested in the Moffitt dataset. RESULTS A high score was significantly associated with increased risk of metastasis and death from colon cancer across all pathologic stages and specifically in stage II and stage III patients. The metastasis score was shown to independently predict risk of cancer recurrence and death in univariate and multivariate models. For example, among stage III patients, a high score translated to increased relative risk of cancer recurrence (hazard ratio, 4.7; 95% confidence interval, 1.566-14.05). Furthermore, the metastasis score identified patients with stage III disease whose 5-year recurrence-free survival was >88% and for whom adjuvant chemotherapy did not increase survival time. CONCLUSION A gene expression profile identified from an experimental model of colon cancer metastasis predicted cancer recurrence and death, independently of conventional measures, in patients with colon cancer.


PLOS ONE | 2013

Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma.

Nicole T. Al-Greene; Anna L. Means; Pengcheng Lu; Aixiang Jiang; Carl R. Schmidt; A. Bapsi Chakravarthy; Nipun B. Merchant; M. Kay Washington; Bing Zhang; Yu Shyr; Natasha G. Deane; R. Daniel Beauchamp

Angiogenesis, the recruitment and re-configuration of pre-existing vasculature, is essential for tumor growth and metastasis. Increased tumor vascularization often correlates with poor patient outcomes in a broad spectrum of carcinomas. We identified four jointed box 1 (FJX1) as a candidate regulator of tumor angiogenesis in colorectal cancer. FJX1 mRNA and protein are upregulated in human colorectal tumor epithelium as compared with normal epithelium and colorectal adenomas, and high expression of FJX1 is associated with poor patient prognosis. FJX1 mRNA expression in colorectal cancer tissues is significantly correlated with changes in known angiogenesis genes. Augmented expression of FJX1 in colon cancer cells promotes growth of xenografts in athymic mice and is associated with increased tumor cell proliferation and vascularization. Furthermore, FJX1 null mice develop significantly fewer colonic polyps than wild-type littermates after combined dextran sodium sulfate (DSS) and azoxymethane (AOM) treatment. In vitro, conditioned media from FJX1 expressing cells promoted endothelial cell capillary tube formation in a HIF1-α dependent manner. Taken together our results support the conclusion that FJX1 is a novel regulator of tumor progression, due in part, to its effect on tumor vascularization.


Clinical Gastroenterology and Hepatology | 2006

Urine PGE-M: A Metabolite of Prostaglandin E2 as a Potential Biomarker of Advanced Colorectal Neoplasia

J. Chad Johnson; Carl R. Schmidt; Martha J. Shrubsole; Dean Billheimer; Prashant R. Joshi; Jason D. Morrow; Martin J. Heslin; M. Kay Washington; Reid M. Ness; Wei Zheng; David A. Schwartz; Robert J. Coffey; R. Daniel Beauchamp; Nipun B. Merchant


Surgery | 2005

E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells

Carl R. Schmidt; Y.J. Gi; Trusharth A. Patel; Robert J. Coffey; R. Daniel Beauchamp; A. Scott Pearson


Journal of Surgical Research | 2005

Physiologic properties of small intestine submucosa1

Benjamin K. Poulose; Stefan Scholz; Derek E. Moore; Carl R. Schmidt; Eric L. Grogan; Oliver B. Lao; Lillian B. Nanney; Jeff Davidson; Michael D. Holzman


American Journal of Surgery | 2003

Dysregulation of E-cadherin by oncogenic ras in intestinal epithelial cells is blocked by inhibiting MAP kinase

Carl R. Schmidt; M. Kay Washington; Y.J. Gi; Robert J. Coffey; R. Daniel Beauchamp; A. Scott Pearson


Surgery | 2004

Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells

Carl R. Schmidt; Y.J. Gi; Robert J. Coffey; R. Daniel Beauchamp; A. Scott Pearson


Archive | 2009

BASIC—ALIMENTARY TRACT Experimentally Derived Metastasis Gene Expression Profile Predicts Recurrence and Death in Patients With Colon Cancer

J. Joshua Smith; Natasha G. Deane; Fei Wu; Nipun B. Merchant; Bing Zhang; Aixiang Jiang; Pengcheng Lu; J. Chad Johnson; Carl R. Schmidt; Christina E. Bailey; Steven Eschrich; Christian Kis; Shawn Levy; M. Kay Washington; Martin J. Heslin; Robert J. Coffey; Timothy J. Yeatman; Yu Shyr; R. Daniel Beauchamp; H.Y. Lee


Cancer Research | 2006

Targeted loss of E-cadherin is sufficient to induce dedifferentiation, loss of intercellular junctions, and increased invasive potential of colorectal cancer cells

Allison R. Hatmaker; Young Jin Gi; Carl R. Schmidt; R. Daniel Beauchamp; Robert J. Coffey; A. Scott Pearson


Current Surgery | 2004

Learning the spirituality of life and medicine from others

Carl R. Schmidt

Collaboration


Dive into the Carl R. Schmidt's collaboration.

Top Co-Authors

Avatar

R. Daniel Beauchamp

Vanderbilt University Medical Center

View shared research outputs
Top Co-Authors

Avatar

Robert J. Coffey

Vanderbilt University Medical Center

View shared research outputs
Top Co-Authors

Avatar

M. Kay Washington

Vanderbilt University Medical Center

View shared research outputs
Top Co-Authors

Avatar

A. Scott Pearson

Vanderbilt University Medical Center

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Y.J. Gi

Vanderbilt University Medical Center

View shared research outputs
Top Co-Authors

Avatar

Aixiang Jiang

Vanderbilt University Medical Center

View shared research outputs
Top Co-Authors

Avatar

Bing Zhang

Baylor College of Medicine

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge