Carl R. Schmidt
Vanderbilt University Medical Center
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Carl R. Schmidt.
Gastroenterology | 2010
J. Joshua Smith; Natasha G. Deane; Fei Wu; Nipun B. Merchant; Bing Zhang; Aixiang Jiang; Pengcheng Lu; J. Chad Johnson; Carl R. Schmidt; Christina E. Bailey; Steven Eschrich; Christian Kis; Shawn Levy; M. Kay Washington; Martin J. Heslin; Robert J. Coffey; Timothy J. Yeatman; Yu Shyr; R. Daniel Beauchamp
BACKGROUND & AIMS Staging inadequately predicts metastatic risk in patients with colon cancer. We used a gene expression profile derived from invasive, murine colon cancer cells that were highly metastatic in an immunocompetent mouse model to identify patients with colon cancer at risk of recurrence. METHODS This phase 1, exploratory biomarker study used 55 patients with colorectal cancer from Vanderbilt Medical Center (VMC) as the training dataset and 177 patients from the Moffitt Cancer Center as the independent dataset. The metastasis-associated gene expression profile developed from the mouse model was refined with comparative functional genomics in the VMC gene expression profiles to identify a 34-gene classifier associated with high risk of metastasis and death from colon cancer. A metastasis score derived from the biologically based classifier was tested in the Moffitt dataset. RESULTS A high score was significantly associated with increased risk of metastasis and death from colon cancer across all pathologic stages and specifically in stage II and stage III patients. The metastasis score was shown to independently predict risk of cancer recurrence and death in univariate and multivariate models. For example, among stage III patients, a high score translated to increased relative risk of cancer recurrence (hazard ratio, 4.7; 95% confidence interval, 1.566-14.05). Furthermore, the metastasis score identified patients with stage III disease whose 5-year recurrence-free survival was >88% and for whom adjuvant chemotherapy did not increase survival time. CONCLUSION A gene expression profile identified from an experimental model of colon cancer metastasis predicted cancer recurrence and death, independently of conventional measures, in patients with colon cancer.
PLOS ONE | 2013
Nicole T. Al-Greene; Anna L. Means; Pengcheng Lu; Aixiang Jiang; Carl R. Schmidt; A. Bapsi Chakravarthy; Nipun B. Merchant; M. Kay Washington; Bing Zhang; Yu Shyr; Natasha G. Deane; R. Daniel Beauchamp
Angiogenesis, the recruitment and re-configuration of pre-existing vasculature, is essential for tumor growth and metastasis. Increased tumor vascularization often correlates with poor patient outcomes in a broad spectrum of carcinomas. We identified four jointed box 1 (FJX1) as a candidate regulator of tumor angiogenesis in colorectal cancer. FJX1 mRNA and protein are upregulated in human colorectal tumor epithelium as compared with normal epithelium and colorectal adenomas, and high expression of FJX1 is associated with poor patient prognosis. FJX1 mRNA expression in colorectal cancer tissues is significantly correlated with changes in known angiogenesis genes. Augmented expression of FJX1 in colon cancer cells promotes growth of xenografts in athymic mice and is associated with increased tumor cell proliferation and vascularization. Furthermore, FJX1 null mice develop significantly fewer colonic polyps than wild-type littermates after combined dextran sodium sulfate (DSS) and azoxymethane (AOM) treatment. In vitro, conditioned media from FJX1 expressing cells promoted endothelial cell capillary tube formation in a HIF1-α dependent manner. Taken together our results support the conclusion that FJX1 is a novel regulator of tumor progression, due in part, to its effect on tumor vascularization.
Clinical Gastroenterology and Hepatology | 2006
J. Chad Johnson; Carl R. Schmidt; Martha J. Shrubsole; Dean Billheimer; Prashant R. Joshi; Jason D. Morrow; Martin J. Heslin; M. Kay Washington; Reid M. Ness; Wei Zheng; David A. Schwartz; Robert J. Coffey; R. Daniel Beauchamp; Nipun B. Merchant
Surgery | 2005
Carl R. Schmidt; Y.J. Gi; Trusharth A. Patel; Robert J. Coffey; R. Daniel Beauchamp; A. Scott Pearson
Journal of Surgical Research | 2005
Benjamin K. Poulose; Stefan Scholz; Derek E. Moore; Carl R. Schmidt; Eric L. Grogan; Oliver B. Lao; Lillian B. Nanney; Jeff Davidson; Michael D. Holzman
American Journal of Surgery | 2003
Carl R. Schmidt; M. Kay Washington; Y.J. Gi; Robert J. Coffey; R. Daniel Beauchamp; A. Scott Pearson
Surgery | 2004
Carl R. Schmidt; Y.J. Gi; Robert J. Coffey; R. Daniel Beauchamp; A. Scott Pearson
Archive | 2009
J. Joshua Smith; Natasha G. Deane; Fei Wu; Nipun B. Merchant; Bing Zhang; Aixiang Jiang; Pengcheng Lu; J. Chad Johnson; Carl R. Schmidt; Christina E. Bailey; Steven Eschrich; Christian Kis; Shawn Levy; M. Kay Washington; Martin J. Heslin; Robert J. Coffey; Timothy J. Yeatman; Yu Shyr; R. Daniel Beauchamp; H.Y. Lee
Cancer Research | 2006
Allison R. Hatmaker; Young Jin Gi; Carl R. Schmidt; R. Daniel Beauchamp; Robert J. Coffey; A. Scott Pearson
Current Surgery | 2004
Carl R. Schmidt