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Featured researches published by Carla B. Frye.


Journal of the American College of Cardiology | 2008

Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis.

Carla B. Frye; Qing Harshaw; Fred H. Edwards; Steven R. Steinhubl; Richard C. Becker

OBJECTIVES The purpose of our multicenter study was to examine the impact of pre-operative administration of clopidogrel on reoperation rates, incidence of life-threatening bleeding, inpatient length of stay, and other bleeding-related outcomes in acute coronary syndrome (ACS) patients requiring cardiopulmonary bypass (coronary artery bypass graft surgery [CABG]) in a broad cross section of U.S. hospitals. BACKGROUND There is relative uncertainty about the relationship between clopidogrel and CABG-associated outcomes in the setting of ACS. METHODS A retrospective cohort analysis was performed of randomly selected ACS patients requiring CABG in 14 hospitals across the U.S. Patients exposed to clopidogrel were compared with those not exposed to clopidogrel within 5 days prior to surgery. RESULTS Of the 596 patients enrolled in the study, 298 had been exposed to clopidogrel within 5 days (Group A). Patients in Group A were more than 3-fold more likely to require reoperation for assessment of bleeding than patients not exposed to clopidogrel (6.4% vs. 1.7% Group B, p = 0.004). Major bleeding occurred in 35% of Group A patients versus 26% of Group B patients (p = 0.049). Length of stay was greater in Group A compared with Group B (9.7 +/- 6.0 days vs. 8.6 +/- 4.7 days, unadjusted p = 0.016). After logistic regression analysis, clopidogrel exposure within 5 days of CABG was the strongest predictor of reoperation (odds ratio [OR]: 4.60, 95% confidence interval [CI]: 1.45 to 14.55) and major bleeding (OR: 1.824, 95% CI: 1.106 to 3.008). CONCLUSIONS After ACS, patients who undergo CABG within 5 days of receiving clopidogrel are at increased risk for reoperation, major bleeding, and increased length of stay. These risks must be balanced by the clinical benefits of clopidogrel use demonstrated in randomized clinical trials.


Pharmacotherapy | 2008

Clopidogrel-associated bleeding and related complications in patients undergoing coronary artery bypass grafting.

A. Simon Pickard; Richard C. Becker; Glen T. Schumock; Carla B. Frye

Objective. To determine if clopidogrel use before coronary artery bypass grafting (CABG) is associated with an increase in major bleeding, hemorrhage‐related complications, or transfusion requirements.


Pain | 2015

National Breakthrough Pain Study: prevalence, characteristics, and associations with health outcomes.

Arvind Narayana; Nathaniel P. Katz; Alicia C. Shillington; Judith J. Stephenson; Qing Harshaw; Carla B. Frye; Russell K. Portenoy

Abstract The National Breakthrough Pain Study is a large observational study that assessed breakthrough pain (BTP) in a population of commercially insured community-dwelling patients with opioid-treated chronic pain. Eligible patients were identified from an administrative claims database, and consenting patients were asked to complete a structured telephone interview and several validated questionnaires. Questionnaires assessed pain interference with function (Brief Pain Inventory-Short Form), health status (Short Form 12 [SF-12] Health Survey), disability (Sheehan Disability Scale), work performance (World Health Organization Health and Work Performance Questionnaire), and mood (Generalized Anxiety Disorder-7 Screener [GAD-7] and Patient Health Questionnaire-2 [PHQ-2]). Of 2198 patients interviewed, 1278 patients had persistent pain controlled with opioid therapy; 1023 (80%) of these patients reported BTP. Patients had a median of 2.0 episodes of BTP per day (range, 1-50) and a median duration of BTP of 45 minutes (range, 1-720). Compared with patients without BTP, patients with BTP had more pain-related interference in function (Brief Pain Inventory, mean ± SD: 34.2 ± 15.6 vs 25.0 ± 15.7 [P < 0.001]), worse physical health (SF-12 physical component score: 29.9 ± 9.6 vs 35.1 ± 10.4 [P < 0.001]) and mental health (SF-12 mental component score: 47.4 ± 11.3 vs 49.3 ± 10.4 [P < 0.001]), more disability (Sheehan Disability Scale global impairment score: 15.1 ± 9.1 vs 10.6 ± 8.5; World Health Organization Health and Work Performance Questionnaire absolute absenteeism: 12.4 ± 59.9 vs 7.7 ± 44.9 hours [both P < 0.001]), and worse mood (GAD-7 score: 7.4 ± 5.9 vs 5.9 ± 5.4; PHQ-2 anhedonia score: 1.2 ± 1.1 vs 0.9 ± 1.0 [both P < 0.001]). In this population of community-dwelling patients with opioid-treated chronic pain, BTP was highly prevalent and associated with negative outcomes. This burden of illness suggests the need for specific treatment plans.


Postgraduate Medicine | 2016

Knowledge of binge eating disorder: a cross-sectional survey of physicians in the United States

Dylan Supina; Barry K. Herman; Carla B. Frye; Alicia C. Shillington

ABSTRACT Objectives: Binge eating disorder (BED)—now a designated disorder in the DSM-5—is the most prevalent eating disorder (ED), affecting 2–3% of the US population. This survey of US physicians assesses how BED is diagnosed, treated and referred. Methods: Internists, family practitioners, obstetrics/gynecologist (OB/GYNs) and psychiatrists were randomly selected from a nationally-representative panel. Participants completed an online survey and reviewed case vignettes consistent with DSM-5-defined BED, then answered questions to elicit whether they would assess for psychiatric conditions including EDs. Those reporting they would screen and who correctly identified BED in vignettes received additional questions about BED diagnosis, treatment, and referral patterns. Results: Of 278 physicians surveyed, 96% were board-certified and 87% had practiced >10 years. 23% were psychiatrists, 27% family practitioners, 31% internists and 19% OB/GYNs. 92% were ‘somewhat likely’ to screen for ED after reviewing DSM-5-consistent vignettes. 206 (74%) correctly identified BED. Of these, 33% and 68% reported they proactively screen eating habits for all patients and obese patients, respectively. 10% reported not screening eating habits even in the presence of ED symptoms. Fewer than half reported using DSM criteria in Diagnosing BED, and 56 (27%) did not recognize BED to be a discreet ED. Conclusion: Although ED awareness is improving, understanding BED as a distinct ED is lacking, which may result in low rates of screening and diagnosis. This study illustrates how taking a complete patient history (including probing BED characteristics) may be an effective first-line strategy for clinicians to facilitate optimal care for these patients.


Pharmacotherapy | 1998

Angioedema and photosensitive rash induced by valsartan

Carla B. Frye; Timothy J. Pettigrew


Journal of Thrombosis and Thrombolysis | 2012

Bleeding-associated outcomes with preoperative clopidogrel use in on- and off-pump coronary artery bypass.

Peter M. Herout; Qing Harshaw; Steven R. Steinhubl; Carla B. Frye; Richard C. Becker


Annals of Pharmacotherapy | 1998

Using Literature in Health Care: Reflections on “The Yellow Wallpaper”

Carla B. Frye


ASCO Meeting Abstracts | 2013

Effect of breakthrough pain on functional status, pain interference, and disability in cancer patients: Findings from the national breakthrough pain survey.

Arvind Narayana; Nathaniel P. Katz; Alicia C. Shillington; Judith J. Stephenson; Carla B. Frye; Russell K. Portenoy


American Journal of Kidney Diseases | 2010

186: Comparative Efectiveness of Paricalcitol Versus Calcitriol Treatment in Chronic Kidney Disease [CKD] Patients With Secondary Hyperparathyroidism [SHPT]

Steven E. Marx; Carla B. Frye; Samina Khan; Qing Harshaw; Paul Audhya; Katie Deering; Raimund Sterz


American Journal of Kidney Diseases | 2010

187: Dialysis Health Outcomes Associated With Pre-Dialysis Use of Paricalcitol Compared With No Vitamin D Receptor (VDR) Activator Treatment

Steven E. Marx; Carla B. Frye; Samina Khan; Qing Harshaw; Paul Audhya; Katie Deering; Raimund Sterz

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Qing Harshaw

University of Minnesota

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Richard C. Becker

University of Cincinnati Academic Health Center

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Russell K. Portenoy

Albert Einstein College of Medicine

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A. Simon Pickard

University of Illinois at Chicago

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