Carla Heise
Chiron Corporation
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Publication
Featured researches published by Carla Heise.
Nature Medicine | 2000
Carla Heise; Terry Hermiston; Leisa Johnson; Gabriel Brooks; Adam Sampson-Johannes; Angelica Williams; Lyndah Hawkins; David Kirn
Replication-selective oncolytic viruses constitute a rapidly evolving and new treatment platform for cancer. Gene-deleted viruses have been engineered for tumor selectivity, but these gene deletions also reduce the anti-cancer potency of the viruses. We have identified an E1A mutant adenovirus, dl922-947, that replicates in and lyses a broad range of cancer cells with abnormalities in cell-cycle checkpoints. This mutant demonstrated reduced S-phase induction and replication in non-proliferating normal cells, and superior in vivo potency relative to other gene-deleted adenoviruses. In some cancers, its potency was superior to even wild-type adenovirus. Intravenous administration reduced the incidence of metastases in a breast tumor xenograft model. dl922-947 holds promise as a potent, replication-selective virus for the local and systemic treatment of cancer.
Blood | 2005
Suzanne Trudel; Zhi Hua Li; Ellen Wei; Marion Wiesmann; Hong Chang; Christine Chen; Donna Reece; Carla Heise; A. Keith Stewart
Archive | 2003
Paul A. Barsanti; Dirksen E. Bussiere; Stephen D. Harrison; Carla Heise; Johanna M. Jansen; Elisa Jazan; Timothy D. Machajewski; Christopher Mcbride; William R. Mccrea; Simon Ng; Zhi-Jie Ni; Sabina Pecchi; Keith B. Pfister; Savithri Ramurthy; Paul A. Renhowe; Cynthia Shafer; Joel B. Silver; Allan S. Wagman; Marion Wiesmann; Kelly Wayman
Bioorganic & Medicinal Chemistry Letters | 2006
Christopher Mcbride; Paul A. Renhowe; Carla Heise; Johanna M. Jansen; Gena Lapointe; Sylvia Ma; Ramon Piñeda; Jayesh Vora; Marion Wiesmann; Cynthia Shafer
Archive | 2005
Carla Heise; Sang H. Lee
Cancer Research | 2006
Eleni Venetsanakos; Darrin D. Stuart; Nguyen Tan; Helen Ye; Fernando Salangsang; Kimberley Aardalen; Michel Faure; Carla Heise; Dirk Mendel; Bahija Jallal
Archive | 2006
Daniel Menezes; Carla Heise; Xiaohua Xin
Archive | 2005
Kimberly Denis-Mize; Carla Heise; Daniel Menezes; Susan E. Wilson
Archive | 2006
Kimberly Denis-Mize; Carla Heise; Daniel Menezes; Susan E. Wilson
Archive | 2005
Kimberly Denis-Mize; Carla Heise; Daniel Menezes; Susan E. Wilson