Carlo E. Grossi

Factors affecting the formation and dissolution of experimental thrombi

Abstract The use of the serum-induced clot as a standard experimental model has been found to be highly satisfactory. In twenty-two dogs the effectiveness of fibrinolytic therapy of fresh clots was studied. Systemic fibrinolysin therapy was found to be effective in dissolving such clots, although local administration of fibrinolysin to the clot was found to result in even more rapid lysis. No difference was found in the susceptibility of fresh arterial and venous clots to treatment. In twenty-one dogs the effect of the age of the clot in relation to treatment with fibrinolysin was studied. Clots treated within four days of formation were susceptible to partial or total dissolution. The effect of hyperfibrinogenemia on clot dissolution was studied in ten dogs. Clots formed in the hyperfibrinogenemic state were significantly more resistant to fibrinolytic therapy.