Carlo Iavarone

Structure of eucommiol, a new cyclopentenoid-tetrol from Eucommia Ulmoides

Abstract Isolation of Eucommiol a new cylopentenoid-tetrol from Eucommia Ulmoides (Eucommiaceae) is described. Its structure and absolute stereochemistry have been demonstrated.

1-O-β-d-glucopyranosyleucommiol, an iridoid glucoside from Aucuba japonica

Abstract Eucommiol and a new eucommiol glucoside (eucommioside II) were isolated from Aucuba japonica , besides known aucubin. The structure of eucommioside

Contact dermatitis to Alstroemeria

A study was carried out on 50 workers in a floriculture centre to evaluate the incidence of contact dermatitis to Alstroemeria. 3 subjects gave positive reactions to aqueous and ethanolic extracts of cut flowers, stems and leaves. By column chromatography, the allergen was isolated and its chemical structure identified as 6‐tuliposide A by proton magnetic resonance and carbon‐13 magnetic resonance. Only 6‐tuliposide A was isolated from cut flowers, and this gave positive reactions when patch tested at 0.01%; α‐methylene‐γ‐butyrolactone at 10−5 (v/v) wits positive in the same 3 subjects. Other lactones (γ‐methylene‐γ‐butyrolactone, alantolactone, isoalantolactone) were negative at all concentrations used.

Mollugoside, an iridoid glucoside from Galium mollugo

Abstract Mollugoside, a new iridoid glucoside isolated from Galium mollugo , has been characterized as the 8α-hydroxyapodanthoside by simple chemical transformations and comparison of 13 C NMR spectra of mollugoside and monotropein with those of corresponding carboxilate anions.

Structure elucidation of eucommioside (2″-O-β-d-glucopyranosyl eucommiol) from Eucommia ulmoides

Abstract The isolation of eucommioside from Eucommia ulmoides is described. Chemical modifications and spectral evidence identify eucommioside as the 2″- O -β- d -glucopyranosyl derivative of eucommiol, a known cyclopentenoidtetrol previously isolated from the same plant.

6-O-β-d-Xylopyranosylaucubin from Verbascum sinuatum

Abstract Verbascum sinuatum contains, in addition to aucubin and harpagide, four new highly polar iridoid glycosides one of which has been identified as 6- O -β- d -xylopyranosylaucubin on the basis of spectral data and chemical modifications.

5,7-Bisdeoxycynanchoside, an iridoid glucoside from Macfadyena cynanchoides

Abstract A new iridoid glucoside from Macfadyena cynanchoides leaves has been identified by spectral ( 1 H and 13 C NMR) and chemical procedures as 5,7

Partial synthesis of isoeucommiol, a new cyclop entenoid-tetrol

Abstract Isoeucommiol 3, a cyclopentenoid-tetrol isomer of eucommiol 1, has been prepared by NaBH4 reduction of the hemiacetal moiety of aucubigenin 4a. The mechanism of this reduction has been investigated by using NaBD4.

Cynanchoside, a highly oxygenated iridoid glucoside from Macfadyena cynanchoides

Abstract The elucidation of the structure and stereochemistry of cynanchoside, a new highly oxygenated iridoid glucoside isolated from Macfadyena cynanchoides (Bignoniaceae), has been accomplished using mainly 1 H and 13 C NMR spectral data and further confirmed by simple chemical transformations.

Iridoid aglycones from Deutzia scabra

Abstract Scabrogenin and deutziogenin, the stable aglycones of known iridoid glucosides scabroside and deutzioside, have been isolated from Deutzia scabra . Their structures and mutarotational equilibria were investigated by detailed analysis of 1 H NMR and 13 C NMR data.