Carlos Fava
Fundación Favaloro
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Featured researches published by Carlos Fava.
Journal of Neurosurgery | 2012
Oscar Mendiz; Luciano A. Sposato; Nicolás Fabbro; Gustavo Lev; Analia Calle; León Valdivieso; Carlos Fava; Francisco Klein; Teresa Torralva; Ezequiel Gleichgerrcht; Facundo Manes
OBJECT Executive functions are crucial for organizing and integrating cognitive processes. While some studies have assessed the effect of carotid artery stenting (CAS) on cognitive functioning, results have been conflicting. The object of this study was to assess the effect of CAS on cognitive status, with special interest on executive functions, among patients with severe asymptomatic internal carotid artery (ICA) stenosis. METHODS The authors prospectively assessed the neuropsychological status of 20 patients with unilateral asymptomatic extracranial ICA stenosis of 60% or more by using a comprehensive assessment battery focused on executive functions before and after CAS. Individual raw scores on neuropsychological tests were converted into z scores by normalizing for age, sex, and years of education. The authors compared baseline and 3-month postoperative neuropsychological scores by using Wilcoxon signed-rank tests. RESULTS The mean preoperative cognitive performance was within normal ranges on all variables. All patients underwent a successful CAS procedure. Executive function scores improved after CAS, relative to baseline performance as follows: set shifting (Trail-Making Test Part B: -0.75 ± 1.43 vs -1.2 ± 1.48, p = 0.003) and processing speed (digit symbol coding: -0.66 ± 0.85 vs -0.97 ± 0.82, p = 0.035; and symbol search: -0.24 ± 1.32 vs -0.56 ± 0.77, p = 0.049). The benefit of CAS for working memory was marginally significant (digit span backward: -0.41 ± 0.61 vs -0.58 ± 0.76, p = 0.052). Both verbal (immediate Rey Auditory Verbal Learning Test: 0.35 ± 1.04 vs -0.22 ± 0.82, p = 0.011) and visual (delayed Rey-Osterrieth Complex Figure: 0.27 ± 1.26 vs -0.22 ± 1.01, p = 0.024) memory improved after CAS. CONCLUSIONS The authors found a beneficial effect on executive function and memory 3 months after CAS among their prospective cohort of consecutive patients with unilateral and asymptomatic ICA stenosis of 60% or more.
Vascular and Endovascular Surgery | 2011
Oscar Mendiz; Alberto H. Sampaolesi; Hugo Londero; Carlos Fava; Gustavo Lev; León Valdivieso
We report our experience using transradial access (TRA) for carotid artery stenting (CAS). Eighty-eight patients underwent CAS using a nonfemoral approach, 79 of them by TRA. Carotid artery stenting was performed using standard techniques with a long hydrophilic sheath. Mean age was 69.5 years. A total of 46 patients were symptomatic and 34 were asymptomatic. Transradial access and procedural success were achieved in 98.8% and 96.6% of the cases, respectively. There were no deaths, myocardial infarction, or radial access site complications. In all, 2 patients sustained a stroke, 1 hemorrhage, and 1 ischemia. Carotid artery stenting using TRA was safe and technically feasible.
Angiology | 2011
Oscar Mendiz; Carlos Fava; León Valdivieso; Gustavo Lev; Lorena Villagra
Objective: To report our experience in patients with critical limb ischemia (CLI) due to isolated below-the-knee (BTK) arterial lesions. Methods: Between 1992 and 2009, we performed 2747 peripheral angioplasties, while 2.8% (78 of 2747) were only BTK and were included in the present study. Results: Mean age was 70.2 ± 11 years, 58.4% had diabetic, 85.7% were smokers, and 20.8% had chronic renal failure. Baseline Rutherford class: 50 patients with class IV and 27 with class V to VI. Angiographic and clinical success were 97.4% and 90.91%, respectively. At 30 days, there were no deaths, 2 patients had acute vessel closure and 2 major amputation. At long-term follow-up (22.4 ± 9.6 months), there were 7 unrelated deaths (10%), 5 amputations (7.1%), 3 reinterventions (4.2%), while 16 patients remained symptomatic. Overall amputation and amputation plus claudication-free survival were 90% and 70%, respectively. Conclusion: Endovascular treatment of BTK lesions represents a safe and effective treatment option to patients with CLI.
Coronary Artery Disease | 2005
Jorge A. Belardi; Fernando Cura; Mariano Albertal; Lucio Padilla; German Solioz; Pablo Pérez Baliño; Julio A. Pascua; Carlos Fava; Daniel Berrocal; Oscar Mendiz; Liliana Grinfeld
BackgroundAlthough target lesion revascularization (TLR) has been dramatically decreased by using drug-eluting stents (DESs) in de-novo lesions, their efficacy for in-stent restenosis (ISR) has not yet been well established. MethodsWe retrospectively analysed patients treated for ISR with DESs from three referral hospitals. ResultsEighty-seven consecutive patients, from June 2002 to April 2004, were included, with a mean age of 64±11 years; 83% were men, 32% had diabetes, 47% had had a previous myocardial infarction and 16% had low left ventricular ejection fraction. Angiographic characteristics were as follows: mean vessel diameter, 3.05±0.4 mm; lesion length, 17.8±7.7 mm; diameter stenosis, 84.0±10.7%; and complex lesion, 81%. The restenosis was focal in 45%, diffuse/proliferative in 51.3% and total occlusion in 3.7% of the cases. Sirolimus- and paclitaxel-eluting stents were used in 42 and 58% of the patients, respectively. Stent diameter was 3.1±0.3 mm and the length was 26.1±5.8 mm. Angiographic success was achieved in all patients, with one patient experiencing a post-procedural non-Q-wave myocardial infarction. At 6-month clinical follow-up, two patients had died from non-cardiac deaths, five had experienced a new TLR (5.7%, four percutaneous and one coronary artery bypass graft) and eight (9.2%) had had major adverse cardiac events. A stress test was performed in 60% of the population; target vessel ischemia was observed in one patient (3.3%). ConclusionIn this non-select cohort of patients, the use of DESs is a safe and effective strategy for ISR lesions.
Angiology | 2012
Oscar Mendiz; Waqar H. Ahmed; Carlos Fava; Jürgen vom Dahl; León Valdivieso; Gustavo Lev; Martyn Thomas
We evaluated the incidence of clinical events after implantation of the TAXUS Liberté paclitaxel-eluting stent in saphenous vein graft (SVG) lesions in an unselected patient population. The OLYMPIA (TAXUS Liberté Post-Approval Global Registry) program gathered data on 21 954 patients receiving at least 1 TAXUS Liberté stent, including 345 patients with SVG lesions. All cardiac events were monitored with independent adjudication of end points. Patients enrolled at procedure started with no mandated inclusion/exclusion criteria. In SVG-OLYMPIA (n = 345), baseline comorbidities/complex disease were more frequent than the rest of the OLYMPIA (n = 21 560). SVG-OLYMPIA had similar cardiac death, target vessel revascularization, and definitive stent thrombosis rates than the rest of OLYMPIA. Despite higher baseline risk, the SVG-OLYMPIA had similar 12-month clinical outcome than the rest of the OLYMPIA registry, confirming the safety and efficacy of the TAXUS Liberté stent in this high-risk group.
Cardiovascular Revascularization Medicine | 2017
Oscar Mendiz; Carlos Fava; Miguel Cerdá; Gustavo Lev; Gaspar Caponi; León Valdivieso
Transcatheter aortic valve replacement (TAVR) represents a viable therapeutic option in patients with severe symptomatic aortic valve stenosis. The development of a left ventricular pseudoaneurysm (LVP) represents an infrequent but potentially catastrophic complication after transapical TAVR. In this case report, we present a patient undergoing TAVR through subclavian access which had an LVP and underwent successful percutaneous closure.
Annals of Vascular Surgery | 2016
Oscar Mendiz; Hugo Fraguas; Carlos Fava
The treatment of an aortic arch aneurysm in high-risk individuals poses a significant challenge. We present a surgical patient with a patent left internal mammary artery (LIMA) graft and a large aortic arch aneurysm who underwent aortic stent-graft implantation and complete endovascular branching to preserve the LIMA inflow, with successful exclusion of the aneurysm. A moderate flow, proximal type I endoleak was observed after deployment that disappeared at 2-year follow-up.
Indian heart journal | 2017
Oscar Mendiz; Carlos Fava; Fernando Cura; Carla Agatiello; Matías Sztejfman; Aníbal Damonte; Hugo Londero; Alfonsina Candiello; Daniel Berrocal
Background Nonagenarians are mostly denied from different therapeutic strategies due to high preoperative risk. We present the results of nonagenarians with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). Methods Our retrospective analysis include baseline and procedural data along with clinical outcome. Clinical follow-up was performed in all patients after TAVR. Results Out of 689 patients, 33 nonagenarians with a mean age of 90.9 ± 1.4 years suffering from severe AS and elevated comorbidity index (logistic EuroSCORE of 16.3 ± 9.6%, STS score 11.1 ± 9.9%) underwent TAVR between September 2009 and July 2016 using self-expanding prosthesis. Baseline transthoracic echocardiography reported a mean aortic valve area (AVA) of 0.64 ± 0.12 cm2 with a mean pressure gradient of 56.1 ± 16.1 mmHg. Five (16.2%) patients had postprocedural moderate/severe aortic regurgitation. One patient died intraoperally due to ventricular perforation during predilatation, while two patients died within the first 30 days, one due to cardiogenic shock and the other due to pneumonia. No patient experienced a myocardial infarction or a stroke, while ten (30.3%) required permanent pacemaker placement. At follow-up (mean 20.3 months, range 1–78 months), all cause and cardiovascular mortality was 24.2% and 15.1%, respectively. Two patients presented heart failure and 12 (40%) had exertional dyspnea. By echo, mean valve area was 1.72 ± 0.12 cm2 and mean gradient 11.2 ± 1.4 mmHg. Two patients (16.7%) presented moderate aortic regurgitation. Conclusion Our case series demonstrate that even with elevated comorbidity index, clinical endpoints and valve-associated results are relatively favorable in nonagenarians treated with TAVR.
Revista Argentina de Cardioangiología Intervencionista | 2016
Carla Agatiello; Alfonsina Candiello; Matías Sztejfman; Carlos Fava; Diego Grinfeld; Ignacio Seropian; Antonio Scuteri; Aníbal Damonte; Juan Mieres; Hugo Londero; Oscar Mendiz; Fernando Cura; Daniel Berrocal; Miguel Payaslian; Alfredo E. Rodriguez; José Álvarez; Claudio Cigalini; Ernesto Torresani
1 Coordinadora: Dra. Carla Agatiello. Comité de Redacción: Dra. Alfonsina Candiello, Dr. Matías Sztejfman, Dr. Carlos Fava, Dr. Diego Grinfeld, Dr. Ignacio Seropian, Dr. Antonio Scuteri, Dr. Aníbal Damonte, Dr. Juan Mieres. Comité de Revisión: Dr. Hugo Londero, Dr. Oscar Mendiz, Dr. Fernando Cura, Dr. Daniel Berrocal, Dr. Miguel Payaslian, Dr. Alfredo Rodríguez, Dr. José Álvarez, Dr. Claudio Cigalini, Dr. Ernesto Torresani, Dr. Arturo Fernández Murga, Dr. José Gómez Moreno, Dr. Marcelo Menéndez, Dr. Alejandro Cherro, Dr. Jorge Baccaro, Dr. Alejandro Álvarez
Revista Brasileira de Cardiologia Invasiva | 2009
Carlos Fava; León Valdivieso; Gustavo Lev; Lorena Villagra; Gaspar Caponi; Antonio Semiglia; Eduardo Torres; Oscar Mendiz
BACKGROUND: Carotid lesions are observed in 8% to 14% of cardiovascular surgery candidates and increase the risk of perioperative stroke. This is particularly important in patients with coronary disease and/or severe valve disease who are not candidate to revascularization procedures at different time points. We assessed the results of a hybrid strategy, where carotid angioplasty and cardiovascular surgery were performed sequentially with an interval of a few hours. METHOD: Carotid lesions > 70% in symptomatic patients and > 80% in asymptomatic patients were treated. Acetylsalicylic acid was administered prior to carotid stenting and heparin was administered at the time of the procedure. Once the percutaneous intervention was over, patients were transferred to the surgery room to carry out the cardiovascular procedure. Clopidogrel was administered 8 hours after the end of the surgery. RESULTS: Forty-three consecutive patients were included and treated with the hybrid strategy. Male patients (81%) were prevalent, with mean age of 70.5 ± 8.5 years, and 25.6% were diabetic. A cerebral protection system was used in 42 patients and stents were implanted in all of them. Coronary artery bypass graft (CABG) was performed in 20 patients, CABG + aortic valve replacement (AVR) in 18, CABG + ascending aorta repair in 1, CABG + mitral valve annuloplasty in 1, CABG + mitral valve replacement (MVR) in 1, AVR in 1 and MVR in 1. Hospital results showed 4 deaths (2 due to multiple organ failure, 1 due to heart failure and 1 to bleeding), 1 case of perioperative acute myocardial infarction and no strokes. Late follow-up was performed in all of the patients at 25 ± 15 months. After hospital discharge, there were two deaths not related to the percutaneous or surgical procedures and no neurological events. CONCLUSION: A hybrid strategy combining carotid stenting and cardiovascular surgery is feasible and safe with an acceptable complication rate. It may be a good option in clinically unstable patients, however, further studies with a large number of patients are required to reproduce our findings.