Carmel J. Hillyard

Plasma-immunoreactive-calcitonin in patients with non-thyroid tumours.

Abstract Increased concentrations of immunoreactive calcitonin were found in plasma samples from twenty-one of forty-six patients with non-thyroid tumours. Further increases in plasma-immunoreactive-calcitonin were observed during calcium infusion in the four patients in whom this test was performed. Increased concentrations of plasma-calcitonin are not diagnostic of medullary carcinoma of the thyroid.

Rifampicin and vitamin D metabolism

A 2‐wk course of rifampicin orally (600 mg/day) in 8 male subjects resulted in a consistent fall in plasma 25‐hydroxycholecalciferol (25‐OHD) levels of around 70%, accompanied by increased oxidation of antipyrine and 6β‐hydroxycortisol (indicative of hepatic enzyme induction). Plasma levels of 1,25‐dihydroxycholecalciferol, parathyroid hormone, and calcitonin were not altered. The fall in 25‐OHD may represent the earliest lesion of drug‐induced osteomalacia.

NORMAL PLASMA CALCITONIN: CIRCADIAN VARIATION AND RESPONSE TO STIMULI

A simple, reproducible extraction method has been developed, which is capable of measuring calcitonin in normal individuals. Normal calcitonin levels show a circadian variation, with a peak around midday and respond to known stimuli for calcitonin release.

Regulation of calcium‐regulating hormones by exogenous sex steroids in early postmenopause

Abstract. A major function of calcitonin in humans appears to be maintenance of the skeleton. There is a marked sex difference in circulating calcitonin levels: women have much lower levels. This has led to speculation that calcitonin lack may be one factor involved in the pathogenesis of postmenopausal bone loss.

CALCITONIN IN BREAST AND LUNG CANCER

Immunoreactive calcitonin was found in extracts of seven out of eight consecutive breast carcinomas and four selected lung carcinomas, but not in extracts of benign breast lesions or normal tissues.

The calcitonin gene-related peptide-containing fiber projection from the hypothalamus to the lateral septal area including its fine structures

The afferent source of calcitonin gene-related peptide-like immunoreactive (CGRPI) fibers in the lateral septal area of the rat was sought by using indirect immunofluorescence technique. These fibers decreased markedly on the operated side after the destruction of the area between the anterior hypothalamic nucleus and the lateral hypothalamus where there were a number of CGRPI cells. We also examined the fine structure of CGRPI fibers in the lateral septal area. Many CGRPI fibers forming axosomatic synapses were identified. These facts strongly suggest that CGRPI cells in the area between the anterior hypothalamic nucleus and the lateral hypothalamus project ipsilaterally to the lateral septal area and directly influence the soma there.

Knochenumbau und Calciumphosphat-Stoffwechsel

Knochen besteht aus Mineral-, Matrix-, Wasser-und Fettanteilen. Den geringsten Fettgehalt finden wir im kompakten Knochen, den grosten Fettgehalt im spongiosareichen Epiphysenknochen (Tabelle 1).