Carmen Villaverde

Alkaloids of Sarcocapnos crassifolia subsp. speciosa

Abstract Thirty-four benzylisoquinoline alkaloids were isolated from the aerial parts of Sarcocapnos crassifolia subsp. speciosa . Twenty-seven of them were identified as the following known alkaloids. Benzophenanthridines: 8-hydroxymethyl dihydrosanguinarine, (+)-chelidonine and oxysanguinarine. Ribasines: (+)-ribasine. Aporphinoids: (+)-glaucine, (+)- N -methyl laurotetanine, (+)-isoboldine, O -methyl atheroline and corunnine. Morphinandienones: (−)-pallidine and (+)-salutaridine. 1-Benzylisoquinolines: (+)-crassifoline. Protopines: protopine. Protoberberines: (−)-scoulerine. Cularines and related compounds: (+)-cularine, (+)-cularidine, (+)-celtisine, (+)-breoganine, (+)-sarcocapnidine, (+)-claviculine, oxocularine, oxocompostelline, oxosarcocapnidine, oxosarcophylline, secocularine and secocularidine. Dibenzopyranazepines: (−) clavizepine. The remainder were seven new cularine-type alkaloids which we named (+)-enneaphylline, (+)-sarcophylline, (+)-norsarcocapnidine, oxocularidine, secosarcocapnidine, norsecocularidine and norsecosarcocapnidine. Their structures have been elucidated by spectroscopic and chemical methods.

N-Methylsecoglaucine, a New Phenanthrene Alkaloid from Fumariaceae

The isolation and its total synthesis of the new phenanthrene alkaloid N-methylsecoglaucine from Platycapnos spicata are reported