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Dive into the research topics where Carolina Barbosa Brito da Matta is active.

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Featured researches published by Carolina Barbosa Brito da Matta.


Marine Drugs | 2012

Antinociceptive and Anti-Inflammatory Activities of Crude Methanolic Extract of Red Alga Bryothamnion triquetrum

Luiz Henrique Agra Cavalcante-Silva; Carolina Barbosa Brito da Matta; Morgana Vital de Araújo; José Maria Barbosa-Filho; Daysianne Pereira de Lira; Bárbara Viviana de Oliveira Santos; George Emmanuel C. de Miranda; Magna Suzana Alexandre-Moreira

The marine environment is an extraordinary reservoir of bioactive natural products, many of which exhibit chemical and structural features not found in terrestrial natural products. In this regard, the aim of this study was to investigate the possible antinociceptive and anti-inflammatory activities of a crude methanolic extract of the red alga Bryothamnion triquetrum (BT-MeOH) in murine models. Groups of Swiss mice of both sexes (25–30 g) were used throughout the experiments. The potential antinociceptive of BT-MeOH was evaluated by means of the following tests: acetic acid-induced writhing, hot-plate test and glutamate- and formalin-induced nociception. The anti-inflammatory activity of BT-MeOH was investigated using the zymosan A-induced peritonitis test. The tests were conducted using 100 mg/kg (p.o.) BT-MeOH, 33.3 mg/kg (p.o.) dipyrone, 35.7 mg/kg (p.o.) indomethacin and 5.7 mg/kg (s.c.) morphine. The extract and all standard drugs were administered 40 min before the nociceptive/inflammatory stimulus. In the acetic acid-induced writhing test, BT-MeOH and dipyrone inhibited the nociceptive response by 55.9% (22.2 ± 2.0 writhings; p < 0.01) and 80.9% (9.6 ± 2.1 writhings; p < 0.01). In the hot-plate test, BT-MeOH did not increase the latency time of the animals in the time evaluated. In addition, BT-MeOH inhibited glutamate-induced nociception by 50.1%. While BT-MeOH did not inhibit the neurogenic phase in formalin-induced nociception, the inflammatory phase was inhibited by 53.1% (66.8 ± 14.2 s; p < 0.01). Indomethacin inhibited the inflammatory phase by 60.2% (56.8 ± 8.7 s; p < 0.01). In the zymosan-induced peritonitis test, BT-MeOH inhibited 55.6% (6.6 ± 0.2 × 106 leukocytes/mL; p < 0.01) of leukocyte migration, while indomethacin inhibited 78.1% (3.2 ± 0.1 × 106 leukocytes/mL; p < 0.01). Based on the results obtained in this study, we conclude that BT-MeOH has peripheral antinociceptive and anti-inflammatory activities. However, more studies need to be conducted to confirm these properties.


The Scientific World Journal | 2013

The Antinociceptive and Anti-Inflammatory Activities of Aspidosperma tomentosum (Apocynaceae)

Anansa Bezerra de Aquino; Luiz Henrique Agra Cavalcante-Silva; Carolina Barbosa Brito da Matta; Willians Antônio do Nascimento Epifânio; Pedro Gregório Vieira Aquino; Antônio Euzébio Goulart Sant'Ana; Magna Suzana Alexandre-Moreira; João Xavier de Araújo-Júnior

We investigated the antinociceptive and anti-inflammatory activities of the crude ethanolic extract (CEE), its fractions, and the flavonoid isorhamnetin from Aspidosperma tomentosum using models of nociception and inflammation in mice. In the writhing test, the CEE and its fractions (except for soluble phase, CHCl3 100% and EtAcO 100%) at 100 mg/kg p.o. induced antinociceptive activity. Isorhamnetin (100 μmol/kg, p.o.) was also active. In the hot plate test, only the treatment with the fractions Hex : CHCl3 50%, CHCl3 100%, and CHCl3 : MeOH 5% (100 mg/kg, p.o.) increased the latency time, reversed by the opioid antagonist naloxone. Fractions that were active in the hot plate test did not show catalepsy condition. It was observed that CEE, all fractions, and isorhamnetin reduced the formalin effects in the neurogenic phase. In the inflammatory phase, only CEE, isorhamnetin, and CHCl3 100% and CHCl3 : MeOH 5% fractions were active. CEE and all fractions, except for CHCl3 : MeOH 10% fraction, isorhamnetin, and soluble fraction were able to produce an antioedematogenic activity in the ear capsaicin-induced edema test. In the thioglycolate-induced peritonitis, only EtAcO 100% fraction was not active. The results demonstrate that A. tomentosum has antinociceptive and anti-inflammatory activities in animal models.


Molecules | 2014

Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones

Morgana Vital de Araújo; Patricia S. O. de Souza; Aline Cavalcanti de Queiroz; Carolina Barbosa Brito da Matta; Anderson Brandão Leite; Amanda Evelyn da Silva; José Adonias A. de França; Tania Maria Sarmento Silva; Celso A. Camara; Magna Suzana Alexandre-Moreira

A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with various aromatic and aliphatic aldehydes under mild acidic conditions. The title compounds were evaluated for antileishmanial activity in vitro against Leishmania amazonensis and Leishmania braziliensis promastigotes; six compounds showed good activity without significant toxic effects. The compound with the highest activity was used for an in vivo assay with Leishmania amazonensis.


Evidence-based Complementary and Alternative Medicine | 2013

Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit

Rosangela Alves Falcão; Patrícia L. A. Nascimento; Silvana Alves de Souza; Telma Maria Guedes da Silva; Aline Cavalcanti de Queiroz; Carolina Barbosa Brito da Matta; Magna Suzana Alexandre Moreira; Celso A. Camara; Tania Maria Sarmento Silva

Hyptis pectinata, popularly known in Brazil as “sambacaitá” or “canudinho,” is an aromatic shrub largely grown in the northeast of Brazil. The leaves and bark are used in an infusion for the treatment of throat and skin inflammations, bacterial infections, pain, and cancer. Analogues of rosmarinic acid and flavonoids were obtained from the leaves of Hyptis pectinata and consisted of two new compounds, sambacaitaric acid (1) and 3-O-methyl-sambacaitaric acid (2), and nine known compounds, rosmarinic acid (3), 3-O-methyl-rosmarinic acid (4), ethyl caffeate (5), nepetoidin A (6), nepetoidin B (7), cirsiliol (8), circimaritin (9), 7-O-methylluteolin (10), and genkwanin (11). The structures of these compounds were determined by spectroscopic methods. Compounds 1–5, and 7 were evaluated in vitro against the promastigote form of L. braziliensis, and the ethanol extract. The hexane, ethyl acetate, and methanol-water fractions were also evaluated. The EtOH extract, the hexane extract, EtOAc, MeOH:H2O fractions; and compounds 1, 2 and 4 exhibited antileishmanial activity, and compound 1 was as potent as pentamidine. In contrast, compounds 3, 5, and 7 did not present activity against the promastigote form of L. braziliensis below 100 µM. To our knowledge, compounds 1 and 2 are being described for the first time.


Evidence-based Complementary and Alternative Medicine | 2014

Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil

Aline Cavalcanti de Queiroz; Thays de Lima Matos Freire Dias; Carolina Barbosa Brito da Matta; Luiz Henrique Agra Cavalcante Silva; João Xavier de Araújo-Júnior; Givanildo Bernardino de Araújo; Flávia de Barros Prado Moura; Magna Suzana Alexandre-Moreira

This study investigates the leishmanicidal activity of five species of plants used in folk medicine in endemic areas of the state of Alagoas, Brazil. Data were collected in the cities of Colonia Leopoldina, Novo Lino, and União dos Palmares, Alagoas state, from patients with cutaneous leishmaniasis (Leishmania amazonensis) who use medicinal plants to treat this disease. Plants extracts were tested at a concentration of 1–100 μg/mL in all experiments, except in an assay to evaluate activity against amastigotes, when 10 μg/mL was used. All plants extracts did not show deleterious activity to the host cell evidenced by LDH assay at 100, 10, and 1 μg/mL after 48 h of incubation. The plants extracts Hyptis pectinata (L.) Poit, Aloe vera L., Ruta graveolens L., Pfaffia glomerata (Spreng.) Pedersen, and Chenopodium ambrosioides L. exhibited direct activity against extracellular forms at 100 μg/mL; these extracts inhibited growth by 81.9%, 82.9%, 74.4%, 88.7%, and 87.4%, respectively, when compared with promastigotes. The plants extracts H. pectinata, A. vera, and R. graveolens also significantly diminished the number of amastigotes at 10 μg/mL, inhibiting growth by 85.0%, 40.4%, 94.2%, and 97.4%, respectively, when compared with control. Based on these data, we conclude that the five plants exhibited considerable leishmanicidal activity.


Natural Product Research | 2013

Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensis

Anne Dayse Soares da Silva; Luiz Henrique Agra Cavalcante-Silva; Carolina Barbosa Brito da Matta; Diego de Farias Silva; Morgana Vital de Araújo; Josean Fechine Tavares; Marcelo Sobral da Silva; Magna Suzana Alexandre-Moreira

In this study, we investigated the antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID50 = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase. In addition, in glutamate-induced nociception, 7MF inhibited 26% of the nociceptive answer. On the other hand, 7MF did not increase the latency time of the animals in the hotplate test. These results suggest that 7MF has peripheral antinociceptive activity.


Revista Virtual de Química | 2015

Antinociceptive and Anti-inflammatory Effects of Caulerpa kempfii (Caulerpaceae)

Carolina Barbosa Brito da Matta; Luiz Henrique Agra Cavalcante-Silva; João Xavier de Araújo Júnior; George Emmanuel C. de Miranda; Katherine X. Bastos; Jéssica Celestino Ferreira Sousa; Bárbara Viviana de Oliveira Santos; José Maria Barbosa-Filho; Magna Suzana Alexandre Moreira

Marine organisms are a rich source of new prototype drugs, and among them, the seaweeds are a very diverse group with different morphological, structural and metabolic features. The present work was designed to evaluate the antiinflammatory and antinociceptive properties of the hexane (HE), ethyl acetate (EA) and hydroalcoholic (HA) fractions of Caulerpa kempfii in mice. The acetic acid-induced writhing, hot plate and formalin-induced nociception tests were carried out to evaluate the antinociceptive potential of these fractions, while the carrageenan-induced peritonitis test was used to investigate the anti-inflammatory activity of C. kempfii. In the acetic acid-induced writhing test, HE, EA, HA and dipyrone reduced the number of writhings by 76.7, 83.9, 90.8 and 89.3%, respectively. In the hot plate test, C. kempfii fractions did not increase the latency time of the animals in the time evaluated. In the neurogenic phase of the formalin test, the fractions significantly inhibited the pain response by 28.0% (HE), 37.4% (EA), and 35.9% (HA). While in the inflammatory phase, the inhibition was 55.1% (HE), 44.5% (EA) and 54.9% (HA), and indomethacin caused a 62.6% decrease in response. Moreover, in the carrageenan-induced peritonitis test, a reduction in cell migration was seen with all fractions evaluated. The results of this study suggest that HE, EA and HA fractions of C. kempfii have anti-inflammatory and antinociceptive properties. Further studies should be conducted to ensure the safety of C. kempfii as a natural medicine.


Journal of Ethnopharmacology | 2010

The antinociceptive and anti-inflammatory activities of Piptadenia stipulacea Benth. (Fabaceae).

Aline Cavalcanti de Queiroz; Daysianne Pereira de Lira; Thays de Lima Matos Freire Dias; Éverton Tenório de Souza; Carolina Barbosa Brito da Matta; Anansa Bezerra de Aquino; Luiz Henrique Agra Cavalcante Silva; Diogo José Costa da Silva; Eliane Aparecida Campessato Mella; Maria de Fátima Agra; José Maria Barbosa Filho; João Xavier de Araújo-Júnior; Bárbara Viviana de Oliveira Santos; Magna Suzana Alexandre-Moreira


Phytomedicine | 2014

Leishmanicidal activity of the crude extract, fractions and major piperidine alkaloids from the flowers of Senna spectabilis.

Gabriela Muniz de Albuquerque Melo; Marcela Campelo Rodrigues Silva; Thaís Pereira Guimarães; Kátia Mantovani Pinheiro; Carolina Barbosa Brito da Matta; Aline Cavalcanti de Queiroz; Marcos Pivatto; Vanderlan da Silva Bolzani; Magna Suzana Alexandre-Moreira; Claudio Viegas


Applied Clay Science | 2014

Layered double hydroxides (LDHs) as carrier of antimony aimed for improving leishmaniasis chemotherapy

Janaína Menezes; Tamires Gomes da Silva; Jailma Barros dos Santos; Edgar Catari; Mario R. Meneghetti; Carolina Barbosa Brito da Matta; Magna Suzana Alexandre-Moreira; Nereide S. Santos-Magalhães; Luciano Aparecido Meireles Grillo; Camila Braga Dornelas

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Celso A. Camara

Universidade Federal Rural de Pernambuco

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