Carolina Palacios-López

Neonatal vesiculopustular eruption associated with transient myeloproliferative disorder: report of four cases

Background  Transient myeloproliferative disorder (TMD) affects up to 10% of patients with Down syndrome (DS). A small proportion of newborns are asymptomatic and only manifest circulating blast cells, with or without leukocytosis, while others present with hepatomegaly, splenomegaly, serous effusions, and liver fibrosis. Few cases in the literature also have skin manifestations, described as crusted, erythematous, vesiculopustular eruptions occurring mainly on the face, with spreading to the trunk and extremities.

Cutaneous melanoma in private vs. public practices of Mexican dermatologists

6 Terron-Kwiatkowski A, Terrinoni A, Didona B, et al. Atypical epidermolytic palmoplantar keratoderma presentation associated with a mutation in the keratin 1 gene. Br J Dermatol 2004; 150: 1096–1103. 7 Hatsell SJ, Eady RA, Wennerstrand L, et al. Novel splice site mutation in keratin 1 underlies mild epidermolytic palmoplantar keratoderma in three kindreds. J Invest Dermatol 2001; 116: 606–609. 8 Terron-Kwiatkowski A, van Steensel MA, van Geel M, et al. Mutation S233L in the 1B domain of keratin 1 causes epidermolytic palmoplantar keratoderma with “tonotubular” keratin. J Invest Dermatol 2006; 126: 607– 613. 9 Terrinoni A, Puddu P, Didona B, et al. A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus. J Invest Dermatol 2000; 114: 1136–1140. 10 Shimazu K, Tsunemi Y, Hattori N, et al. A novel keratin 9 gene mutation (Met156Arg) in a Japanese patient with epidermolytic palmoplantar keratoderma. Int J Dermatol 2006; 45: 1128–1130.

Imatinib mesylate‐induced neutrophilic folliculitis in a teenager

teenager Imatinib mesylate forms part of the mainstay therapy for chronic lymphocytic leukemia (CML). Cutaneous reactions to the drug are common and occur in 9.5–69% of patients, and a large clinical variety, from self-limiting skin rashes to erythroderma requiring drug withdrawal, has been described. We report the first case of neutrophilic folliculitis associated with the use of imatinib. A 16-year-old girl was diagnosed with CML, chronic phase (Philadelphia chromosome-positive). Treatment was started with imatinib mesylate 400 mg per day with good response. Twenty months later, the dose was raised to 600 mg per day and, three weeks after this, the girl presented with disseminated multiple millimetric erythematous perifollicular papules (Fig. 1), in some areas the papules conformed psoriasiform plaques. The skin biopsy was diagnosed as neutrophilic folliculitis (Fig. 2). Gram and PAS stains were negative for microorganisms. The skin alterations were attributed to the treatment with imatinib, and only regular skin care and emollients were prescribed. The dose of imatinib was not changed but, due to gastrointestinal intolerance, the patient did not take it regularly. Thus, it was involuntarily decreased, and the lesions disappeared in the next month. Imatinib mesylate (Gleevec) is a molecular antagonist of tyrosine kinase. It is an oral agent used as first-line treatment of Philadelphia chromosome-positive CML and gastrointestinal stromal tumors because of its specific inhibition of BCR-ABL. It also inhibits KIT, a product of c-kit and platelet-derived growth factor receptor,

In memoriam: Dr. Ramón Ruiz Maldonado (November 7, 1937-April 5, 2017)

Ram on Ruiz Maldonado was born on November 7, 1937, in the city of Puebla, Mexico, where he received his early education. Since childhood, he was inclined toward medicine, probably influenced by his godfather, Dr. Francisco Casas, a general doctor who Ram on and his parents loved and admired. In 1957 he entered the Faculty of Medicine of the Universidad Nacional Autonoma de Mexico. At the end of his studies he was selected for an internship at the Foch Hospital in Paris, where he worked in the Association of Medical Students and learned French. On his return to Mexico he specialized in dermatology with Professor Fernando Latap ı at the General Hospital of Mexico and at the Dr. Ladislao de la Pascua Dermatological Center. Later, he traveled to Europe and the United States for postgraduate studies in dermatology, mycology, and dermatopathology. He received awards from several governments, and well-recognized professors mentored him, including Robert Degos and Jean Civatte at the St. Louis Hospital in Paris; Franc ois Mariat, Gabriel Segretain, and Edouard Drouhet at the Pasteur Institute in Paris; Albert Wiedmann at the Vienna General Hospital; Jiri Trapl at Charles University in Prague; and Hermann Pinkus at Wayne State University in Detroit, Michigan. During his “academic exile,” his training was not only dermatologic. He learned French, English, German, and Italian. He wrote poetry and even a short novel entitled Saturday Afternoon, published in 1967, which was awarded in the X Literary Contest of “La Hora XXV.” Copies are still available! Upon returning from Europe, Ramon worked in the Pathology Department of the Pascua Dermatologic Center. A year later he was invited to the Children’s Hospital of Mexico as a dermatologist. In 1970, when the National Institute of Pediatrics was inaugurated, Dr. Lazaro Benavides invited Ram on to be head of the Department of Pediatric Dermatology, where he worked for 46 years. From the beginning, he and his colleague and closest collaborator, Dr. Lourdes Tamayo, worked together in a professional and friendly relationship. Three years later they created the specialty in pediatric dermatology at the Universidad Nacional Autonoma de Mexico. Dr. Maldonado and Dr. Tamayo were pioneers in pediatric dermatology in Mexico and in many countries of Latin America. From 1972 to 1995 the only formal course of specialization in pediatric dermatology in the world was that of their department. More than 120 general dermatologists and pediatricians were trained in pediatric dermatology, many of whom serve as heads of various Latin American pediatric dermatology departments. There was a consistency in his professional life of a love of teaching, helping students, and performing research. He was always a committed teacher, sharing his knowledge with anyone who asked. In 1992 the National Institutes of Health in Mexico recognized him as a senior researcher, and he was promoted to the rank of emeritus researcher in 2007. In 1983 Dr. Maldonado joined the National Academy of Medicine of Mexico and in 1989 the National System of Researchers, where he achieved the highest level. In 1989 Dr. Maldonado implemented the recognition of pediatric dermatology as an important branch of general dermatology at the Universidad Nacional Autonoma de Mexico. In 1996 the Mexican Board of Dermatology appointed him president of the Mexican Board of Pediatric Dermatology. He was a professor of dermatology and pediatric dermatology and an academic advisor for the masters and doctoral programs in medical, dental, and health sciences. He mentored 77 students in finishing their theses and in obtaining degrees in pediatrics and pediatric dermatology and masters degrees in medical sciences. From a personal point of view, to work with him and learn from him was a privilege and a pleasure. His contributions in class, from simple aspects such as the proper pronunciation of an author’s name DOI: 10.1111/pde.13319

Dr. Ramón Ruiz Maldonado (1937-2017)

El cruzar en nuestra existencia con un ser humano como el Dr. Ramon Ruiz Maldonado, hombre culto, sensato, ingenioso y maestro en toda la extension de la palabra, ilumina y deja huella. Cuando llega el momento de su partida, por una enfermedad prolongada que mino su cuerpo y termino por encarcelar su mente, la sensacion de vacio y nostalgia es inevitable; solo puede verse hasta cierto punto aliviada por un profundo agradecimiento, ya que aun sin estar presente, su esencia vive en nuestro corazon.