Caroline A.M. Doorenbosch

A clinically applicable EMG-force model to quantify active stabilization of the knee after a lesion of the anterior cruciate ligament

OBJECTIVES To investigate whether a simple electromyography-force (EMG-force) model can be used to measure different levels of co-contraction about the knee for healthy subjects and patients with an anterior cruciate ligament deficiency. DESIGN To evaluate an EMG-to-force processing model, two groups of subjects, with and without deficiency of the anterior cruciate ligament, participated in experiments in which surface EMG, kinematics and kinetics about the knee were recorded during isokinetic and functional movements. BACKGROUND Clinical and biomechanical evidence supports the hypothesis that higher level of co-contraction of quadriceps and hamstrings provide an active stabilization of the knee to compensate for the lost anterior cruciate ligament. To quantify the level of co-contraction, the contribution of both agonist and antagonist muscles to the net joint moment must be known. METHODS Surface EMG levels were calibrated to moment by means of a limited number of isokinetic contractions about the knee. With these calibration values, an estimate of the muscle moments during a vertical jump were obtained and compared with the net joint moment, calculated with inverse dynamics. Also co-contraction indices were determined. RESULTS The EMG-force model provided a fair estimate of the net joint moment. The co-contraction index in anterior cruciate ligament deficient subjects was significantly higher (mean 0.54 (SD, 0.04)) compared to healthy subjects (mean 0.25 (SD, 0.07)). CONCLUSIONS Although the EMG-to-force processing model is not perfectly accurate, it is appropriate within a clinical context. RELEVANCE Previous research supports the hypothesis that subjects with an anterior cruciate ligament deficiency compensate the loss of passive stability by developing higher co-activation levels of the knee muscles, i.e. active stabilization. Quantifying co-contraction may serve as a valuable parameter to evaluate clinical interventions and rehabilitation processes. The EMG-force model presented in this study appears to be a useful instrument for this purpose.

EFFECT OF CARBON-COMPOSITE KNEE-ANKLE-FOOT ORTHOSES ON WALKING EFFICIENCY AND GAIT IN FORMER POLIO PATIENTS

OBJECTIVE To investigate the effects of total-contact fitted carbon-composite knee-ankle-foot orthoses (KAFOs) on energy cost of walking in patients with former polio who normally wear a conventional leather/metal KAFO or plastic/metal KAFO. DESIGN A prospective uncontrolled study with a multiple baseline and follow-up design. Follow-up measurements continued until 26 weeks after intervention. PARTICIPANTS Twenty adults with polio residuals (mean age 55 years). INTERVENTION Each participant received a new carbon-composite KAFO, fitted according to a total-contact principle, which resulted in a rigid, lightweight and well-fitting KAFO. OUTCOME MEASURES Energy cost of walking, walking speed, biomechanics of gait, physical functioning and patient satisfaction. RESULTS The energy cost decreased significantly, by 8%, compared with the original KAFO. Furthermore, the incremention energy cost during walking with the carbon-composite KAFO was reduced by 18% towards normative values. An improvement in knee flexion, forward excursion of the centre of pressure, peak ankle moment, and timing of peak ankle power were significantly associated with the decrease in energy cost. Walking speed and physical functioning remained unchanged. CONCLUSION In patients with former polio, carbon-composite KAFOs are superior to conventional leather/metal and plastic/metal KAFOs with respect to improving walking efficiency and gait, and are therefore important in reducing overuse and maintaining functional abilities in polio survivors.

Reproducibility and validity of video screen measurements of gait in children with spastic cerebral palsy

PURPOSE To determine the reproducibility and validity of video screen measurement (VSM) of sagittal plane joint angles during gait. METHODS 17 children with spastic cerebral palsy walked on a 10m walkway. Videos were recorded and 3d-instrumented gait analysis was performed. Two investigators measured six sagittal joint/segment angles (shank, ankle, knee, hip, pelvis, and trunk) using a custom-made software package. The intra- and interrater reproducibility were expressed by the intraclass correlation coefficient (ICC), standard error of measurements (SEM) and smallest detectable difference (SDD). The agreement between VSM and 3d joint angles was illustrated by Bland-Altman plots and limits of agreement (LoA). RESULTS Regarding the intrarater reproducibility of VSM, the ICC ranged from 0.99 (shank) to 0.58 (trunk), the SEM from 0.81 degrees (shank) to 5.97 degrees (trunk) and the SDD from 1.80 degrees (shank) to 16.55 degrees (trunk). Regarding the interrater reproducibility, the ICC ranged from 0.99 (shank) to 0.48 (trunk), the SEM from 0.70 degrees (shank) to 6.78 degrees (trunk) and the SDD from 1.95 degrees (shank) to 18.8 degrees (trunk). The LoA between VSM and 3d data ranged from 0.4+/-13.4 degrees (knee extension stance) to 12.0+/-14.6 degrees (ankle dorsiflexion swing). CONCLUSION When performed by the same observer, VSM mostly allows the detection of relevant changes after an intervention. However, VSM angles differ from 3d-IGA and do not reflect the real sagittal joint position, probably due to the additional movements in the other planes.

Walking speed modifies spasticity effects in gastrocnemius and soleus in cerebral palsy gait

BACKGROUND The calf muscles of children with cerebral palsy are often spastic, which can lead to an equinus gait pattern. Although spasticity is defined as a velocity-dependent increase in muscle tone, very little is known about the effect of walking speed on muscle-tendon behavior of spastic muscles during gait. The aim of this study was to investigate gastrocnemius and soleus length and lengthening velocity during gait in spastic muscles with and without static contractures compared to non-spastic muscles, as well as the effect of walking speed, and the interacting effect of walking speed and spasticity on muscle-tendon length and lengthening velocity. METHODS Seventeen ambulatory children with spastic cerebral palsy and 11 typically developing children, aged 6-12, walked at comfortable, slow, and fast walking speeds. 3D kinematic data were collected and muscle-tendon lengths and velocities were calculated using musculoskeletal modeling. Spasticity and contractures of calf muscles were measured during standardized physical examination. FINDINGS Spastic calf muscles showed a deviating muscle-tendon length pattern with two peaks in stance, which was found to be irrespective of muscle contracture. This deviating pattern became more pronounced as walking speed increased. In swing, spastic calf muscles were stretched approximately one third slower than normal, while in stance, spastic calf muscles were stretched twice as fast as normal, with peak velocity occurring earlier in the gait cycle. INTERPRETATION The increasingly deviating muscle-tendon length pattern at faster walking speed indicates a velocity-dependent spasticity effect. This impairs walking especially at faster speeds, and may therefore limit comfortable walking speed.

Dynamic spasticity of plantar flexor muscles in cerebral palsy gait

OBJECTIVE To quantify dynamic spasticity, i.e. the coupling between muscle-tendon stretch velocity and muscle activity during gait, of the gastrocnemius and soleus muscles in children with spastic cerebral palsy. DESIGN Prospective, cross-sectional study. SUBJECTS Seventeen ambulatory children with cerebral palsy with spastic calf muscles, and 11 matched typically developing children. METHODS The children walked at 3 different speeds. Three-dimensional kinematic and electromyographic data were collected. Muscle-tendon velocities of the gastrocnemius medialis and soleus were calculated using musculoskeletal modelling. RESULTS In typically developing children, muscles were stretched fast in swing without subsequent muscle activity, while spastic muscles were stretched more slowly for the same walking speed, followed by an increase in muscle activity. The mean ratio between peak activity and peak stretch velocity in swing was approximately 4 times higher in spastic muscles, and increased with walking speed. In stance, the stretch of muscles in typically developing children was followed by an increase in muscle activity. Spastic muscles were stretched fast in loading response, but since muscle activity was already built up in swing, no clear dynamic spasticity effect was present. CONCLUSION Spastic calf muscles showed increased coupling between muscle-tendon stretch velocity and muscle activity, especially during the swing phase of gait.

How Crouch Gait Can Dynamically Induce Stiff-Knee Gait

Children with cerebral palsy frequently experience foot dragging and tripping during walking due to a lack of adequate knee flexion in swing (stiff-knee gait). Stiff-knee gait is often accompanied by an overly flexed knee during stance (crouch gait). Studies on stiff-knee gait have mostly focused on excessive knee muscle activity during (pre)swing, but the passive dynamics of the limbs may also have an important effect. To examine the effects of a crouched posture on swing knee flexion, we developed a forward-dynamic model of human walking with a passive swing knee, capable of stable cyclic walking for a range of stance knee crouch angles. As crouch angle during stance was increased, the knee naturally flexed much less during swing, resulting in a ‘stiff-knee’ gait pattern and reduced foot clearance. Reduced swing knee flexion was primarily due to altered gravitational moments around the joints during initial swing. We also considered the effects of increased push-off strength and swing hip flexion torque, which both increased swing knee flexion, but the effect of crouch angle was dominant. These findings demonstrate that decreased knee flexion during swing can occur purely as the dynamical result of crouch, rather than from altered muscle function or pathoneurological control alone.

The effect of walking speed on hamstrings length and lengthening velocity in children with spastic cerebral palsy

Children with cerebral palsy often walk with reduced knee extension in terminal swing, which can be associated with short length or slow lengthening velocity of hamstrings muscles during gait. This study investigated the role of two factors that may contribute to such short and slow hamstrings: walking speed and spasticity. 17 children with spastic cerebral palsy and 11 matched typically developing children walked at comfortable, slow, and fast walking speed. Semitendinosus muscle-tendon length and velocity during gait were calculated using musculoskeletal modeling. Spasticity of the hamstrings was tested in physical examination. Peak hamstrings length increased only slightly with walking speed, while peak hamstrings lengthening velocity increased strongly. After controlling for these effects of walking speed, spastic hamstrings acted at considerably shorter length and slower velocity during gait than normal, while non-spastic hamstrings did not (all P<0.001). These data are important as a reference for valid interpretation of hamstrings length and velocity data in gait analyses at different walking speeds. The results indicate that the presence of spasticity is associated with reduced hamstrings length and lengthening velocity during gait, even at constant walking speed.

Validation of hamstrings musculoskeletal modeling by calculating peak hamstrings length at different hip angles

Accurate estimates of hamstrings lengths are useful, for example, to facilitate planning for surgical lengthening of the hamstrings in patients with cerebral palsy. In this study, three models used to estimate hamstrings length (M1: Delp, M2: Klein Horsman, M3: Hawkins and Hull) were evaluated. This was done by determining whether the estimated peak semitendinosus, semimembranosus and biceps femoris long head lengths, as measured in eight healthy subjects, were constant over a range of hip and knee angles. The estimated peak hamstrings length depended on the model that was used, even with length normalized to length in anatomical position. M3 estimated shorter peak lengths than M1 and M2, showing that more advanced models (M1 and M2) are more similar. Peak hamstrings length showed a systematic dependence on hip angle for biceps femoris in M2 and for semitendinosus in M3, indicating that either the length was not correctly estimated, or that the specific muscle did not limit the movement. Considerable differences were found between subjects. Large inter-individual differences indicate that modeling results for individual subjects should be interpreted with caution. Testing the accuracy of modeling techniques using in vivo data, as performed in this study, can provide important insights into the value and limitations of musculoskeletal models.

Assessment of muscle endurance of the knee extensor muscles in adolescents with spastic cerebral palsy using a submaximal repetitions-to-fatigue protocol.

OBJECTIVE To compare muscle endurance in adolescents with spastic cerebral palsy (CP) with typically developing (TD) peers using a submaximal repetitions-to-fatigue (RTF) protocol. DESIGN Cross sectional. SETTING Human motion laboratory. PARTICIPANTS Adolescents with spastic CP (n=16; Gross Motor Function Classification System levels I or II) and TD adolescents (n=18) within the age range of 12 to 19 years old. INTERVENTIONS Not applicable. MAIN OUTCOME MEASURES Each participant performed 3 RTF tests at different submaximal loads, ranging from 50% to 90% of their maximal voluntary knee extension torque. The relation between the number of repetitions (repetition maximum [RM]) and imposed submaximal relative (percent of maximal voluntary torque [%MVT]) and absolute (Nm/kg) torque was quantified. To compare adolescents with CP with TD adolescents, a mixed linear model was used to construct load endurance curves. Surface electromyography of quadriceps muscles was measured to assess changes in normalized amplitude and median frequency (MF) as physiological indicators of muscle fatigue. RESULTS Adolescents with CP showed a larger decrease in %MVT per RM than TD adolescents (P<.05). TD adolescents showed substantial higher absolute (Nm/kg) load endurance curves than adolescents with CP (P<.001), but they did not show a difference in slope. Electromyographic normalized amplitude increased significantly (P<.05) in the quadriceps muscles in all tests for both groups. Electromyographic MF decreased significantly (P<.05) in tests with the low and medium loads. Electromyographic responses did not differ between groups, indicating that similar levels of muscle fatigue were reached. CONCLUSIONS Adolescents with CP show slightly lower muscle endurance compared with TD adolescents on a submaximal RTF protocol, which is in contrast with earlier findings in a maximal voluntary fatigue protocol. Accordingly, adolescents with CP have a reduced capacity to endure activities at similar relative loads compared with TD adolescents.

Relations between muscle endurance and subjectively reported fatigue, walking capacity, and participation in mildly affected adolescents with cerebral palsy.

To investigate the relation between muscle endurance and subjectively reported fatigue, walking capacity, and participation in mildly affected adolescents with cerebral palsy (CP) and peers with typical development.