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Dive into the research topics where Caroline Piau is active.

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Featured researches published by Caroline Piau.


Journal of Leukocyte Biology | 2017

Frontline Science: HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock

Murielle Grégoire; Jean-Marc Tadié; Fabrice Uhel; Arnaud Gacouin; Caroline Piau; Nathaniel B. Bone; Yves Le Tulzo; Edward Abraham; Karin Tarte; Jaroslaw W. Zmijewski

Sepsis is accompanied by the initial activation of proinflammatory pathways and long‐lasting immunosuppression that appears to contribute to late‐occurring mortality. Although high‐mobility group box 1 (HMGB1) is involved in many aspects of inflammation, its role in sepsis‐induced immune suppression remains unclear. In this study, we examined HMGB1s contribution to neutrophil NADPH oxidase activity dysfunction and associated neutrophil‐dependent bacterial clearance in mice subjected to sepsis and in patients who survive septic shock. Using a murine model of polymicrobial septic peritonitis, we demonstrated that treatment with anti‐HMGB1 Ab significantly diminished sepsis‐induced dysfunction of neutrophil NADPH oxidase activity. In a subsequent set of experiments, we found that blocking HMGB1 preserved the ability of neutrophils from patients recovering from septic shock to activate NADPH oxidase. Taken together, our data suggest that HMGB1 accumulation in the late phase of sepsis plays a specific role in the development of postsepsis immunosuppression and specifically affects neutrophil‐dependent antibacterial defense mechanisms. Thus, blocking HMGB1 may be a promising therapeutic intervention to diminish the adverse effects of sepsis‐induced immunosuppression.


International Journal of Antimicrobial Agents | 2013

Capnocytophaga spp. involvement in bone infections: a review

Caroline Piau; C. Arvieux; Martine Bonnaure-Mallet; Anne Jolivet-Gougeon

Capnocytophaga are commensal gliding bacteria that are isolated from human and animal oral flora and are responsible for infections both in immunocompromised and immunocompetent hosts. Accumulation of microbial plaque, loss of collagen attachment, and alveolar bone resorption around the tooth can lead to local Capnocytophaga spp. bone infections. These capnophilic bacteria, from oral sources or following domestic animal bites, are also causative agents of bacteraemia and systemic infections as well as osteomyelitis, septic arthritis, and infections on implants and devices. The present literature review describes the main aetiologies of bone infections due to Capnocytophaga spp., the cellular mechanisms involved, methods used for diagnosis, antimicrobial susceptibility, and effective treatments.


Clinical Microbiology and Infection | 2015

Heart transplantation as salvage treatment of intractable infective endocarditis.

Marie Aymami; Matthieu Revest; Caroline Piau; Céline Chabanne; François Le Gall; Bernard Lelong; Jean-Philippe Verhoye; C. Michelet; Pierre Tattevin; Erwan Flecher

This study reports six consecutive patients who underwent heart transplantation as salvage treatment for endocarditis (Duke criteria) with extensive perivalvular lesions and end-stage heart failure. The median age was 45 years (range, 24 to 64), and the aortic valve was affected in all patients. Pathogens were Staphylococcus aureus (n = 2), Streptococcus pneumoniae (n = 2), Streptococcus agalactiae (n = 1), or not documented (n = 1). All patients survived, with no relapse, after a median follow-up of 24.5 months. The 10 patients with heart transplantation for endocarditis previously reported also survived (median follow-up, 27.5 months). Heart transplantation may be considered as salvage treatment in selected patients with intractable infective endocarditis.


Journal of Travel Medicine | 2015

Massive Intra-Alveolar Hemorrhage Caused by Leptospira Serovar Djasiman in a Traveler Returning From Laos

Guillaume Héry; Julien Letheulle; Erwan Flecher; Charlotte Quentin; Caroline Piau; Yves Le Tulzo; Pierre Tattevin

Leptospirosis is one of the most common pathogens responsible for life-threatening tropical disease in travelers. We report a case of massive intra-alveolar hemorrhage caused by Leptospira serovar Djasiman in a 38-year-old man returning from Laos, who was cured with antibiotics and salvage treatment with extra-corporeal membrane oxygenation.


Journal of Clinical Microbiology | 2013

Rombencephalitis Caused by Francisella tularensis

M. Barbaz; Caroline Piau; Jean-Marc Tadié; I. Pelloux; S. Kayal; Pierre Tattevin; Y. Le Tulzo; Matthieu Revest

ABSTRACT Common presentations of tularemia include pneumonia and ulceroglandular, oropharyngeal, or typhoidal disease. Neuromeningeal involvement is extremely rare. We report a case of a severe rhombencephalitis due to Francisella tularensis. Diagnosis was possible thanks to a very precise interview, and the patient dramatically improved after specific antibiotherapy.


Genome Announcements | 2014

Complete Genome Sequence of Streptococcus pyogenes M/emm44 Strain STAB901, Isolated in a Clonal Outbreak in French Brittany

Nicolas Soriano; Pascal Vincent; Caroline Piau; Séverine Moullec; Philippe Gautier; Vincent Lagente; Ahmad Faili; Samer Kayal

ABSTRACT We report the complete genome sequence of an invasive isolate of Streptococcus pyogenes M/emm44, belonging to a clonal outbreak that occurred in French Brittany. The genome is composed of 1,795,608 bp, with a GC content of 38.5%, has 1,358 identified coding sequences (CDSs), and harbors a novel Tn916-like transposon (Tn6253).


Revue Des Maladies Respiratoires | 2017

Nocardiose pulmonaire avec abcès cérébraux mimant un cancer bronchique métastatique : trois cas et revue de la littérature

A. Fourrier; M. Kerjouan; Caroline Piau; P.A. Lentz; C. Ricordel; H. Lena; R. Corre; B. Desrues; Stéphane Jouneau

Nocardiosis is an infectious disease with wide range of clinical features, which can eventually lead to death. The agent responsible belongs to the genus Nocardia that includes about fifty different species. Nocardiosis occurs mainly in immunocompromised hosts. We report here three cases of disseminated nocardiosis misdiagnosed initially as cerebral metastatic lung cancer. These patients, including two immunocompetent hosts, presented with both pulmonary and cerebral lesions. In all three patients, the diagnosis was based on magnetic resonance imaging with diffusion sequence, apparent diffusion coefficient reconstruction and neurosurgical cerebral biopsies. Treatment with an appropriate antibiotic regimen was prolonged for several months. Progress was favorable with full resolution of the neurological symptoms and the radiological abnormalities. These three cases emphasize the diagnostic challenge of nocardiosis, especially in disseminated disease.


Emerging Infectious Diseases | 2015

Opportunistic Pulmonary Bordetella hinzii Infection after Avian Exposure.

Aude Fabre; Clarisse Dupin; François Bénézit; Julien Goret; Caroline Piau; Stéphane Jouneau; Sophie Guillot; Francis Mégraud; Samer Kayal; B. Desrues; Alain Le Coustumier; Nicole Guiso

Diagnosing infections involving this species by routine methods is difficult.


Pediatric Infectious Disease Journal | 2009

Multiple brain abscesses caused by Pseudomonas luteola.

Anne Gaschet; Caroline Piau; Jérémie Violette; Pierre-Yves Donnio; Anne Jolivet-Gougeon; Charlotte Engrand; Pierre Betremieux; Patrick Pladys; Pierre Tattevin


European Journal of Clinical Microbiology & Infectious Diseases | 2012

Distinctive features between community-acquired pneumonia (CAP) due to Chlamydophila psittaci and CAP due to Legionella pneumophila admitted to the intensive care unit (ICU)

A. Gacouin; Matthieu Revest; Julien Letheulle; Pierre Fillatre; S. Jouneau; Caroline Piau; F. Uhel; P. Tattevin; Y. Le Tulzo

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F. Uhel

University of Rennes

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