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Acta Astronautica | 1979

A study of metabolic balance in crewmembers of Skylab IV

P.C. Rambaut; Carolyn S. Leach; G.D. Whedon

A metabolic balance study was conducted on the three crewmembers of the 84-day Skylab IV earth orbital mission. Dietary intake was controlled, monitored, and kept very nearly constant for a period commencing 21 days prior to flight, throughout flight, and for a period of 18 days postflight. Within the first 30 days of flight urine calcium rose to a level approx. 100% above preflight levels and remained elevated for the remainder of the flight. Fecal calcium excretion increased more slowly but continued to accelerate throughout the flight and did not return to baseline levels during the postflight period. Urinary nitrogen increased to 25-30% above preflight levels within one month following launch and thereafter gradually subsided toward control values. The overall losses of calcium averaged approx. 200 mg per day throughout the mission while nitrogen losses averaged 590 mg. Various other indices of musculoskeletal deterioration are discussed and correlated. The parallelism between the effects of weightlessness and bed rest is reviewed. It is noted, that no evidence is yet available as to the identity of the initial biological response to the absence of gravity.


Advances in Space Biology and Medicine | 1997

Regulation of body fluid volume and electrolyte concentrations in spaceflight

Scott M. Smith; Jane M. Krauhs; Carolyn S. Leach

Despite a number of difficulties in performing experiments during weightlessness, a great deal of information has been obtained concerning the effects of spaceflight on the regulation of body fluid and electrolytes. Many paradoxes and questions remain, however. Although body mass, extracellular fluid volume, and plasma volume are reduced during spaceflight and remain so at landing, the changes in total body water are comparatively small. Serum or plasma sodium and osmolality have generally been unchanged or reduced during the spaceflight, and fluid intake is substantially reduced, especially during the first of flight. The diuresis that was predicted to be caused by weightlessness, has only rarely been observed as an increased urine volume. What has been well established by now, is the occurrence of a relative diuresis, where fluid intake decreases more than urine volume does. Urinary excretion of electrolytes has been variable during spaceflight, but retention of fluid and electrolytes at landing has been consistently observed. The glomerular filtration rate was significantly elevated during the SLS missions, and water and electrolyte loading tests have indicated that renal function is altered during readaptation to Earths gravity. Endocrine control of fluid volumes and electrolyte concentrations may be altered during weightlessness, but levels of hormones in body fluids do not conform to predictions based on early hypotheses. Antidiuretic hormone is not suppressed, though its level is highly variable and its secretion may be affected by space motion sickness and environmental factors. Plasma renin activity and aldosterone are generally elevated at landing, consistent with sodium retention, but inflight levels have been variable. Salt intake may be an important factor influencing the levels of these hormones. The circadian rhythm of cortisol has undoubtedly contributed to its variability, and little is known yet about the influence of spaceflight on circadian rhythms. Atrial natriuretic peptide does not seem to play an important role in the control of natriuresis during spaceflight. Inflight activity of the sympathetic nervous system, assessed by measuring catecholamines and their metabolites and precursors in body fluids, generally seems to be no greater than on Earth, but this system is usually activated at landing. Collaborative experiments on the Mir and the International Space Station should provide more of the data needed from long-term flights, and perhaps help to resolve some of the discrepancies between U.S. and Russian data. The use of alternative methods that are easier to execute during spaceflight, such as collection of saliva instead of blood and urine, should permit more thorough study of circadian rhythms and rapid hormone changes in weightlessness. More investigations of dietary intake of fluid and electrolytes must be performed to understand regulatory processes. Additional hormones that may participate in these processes, such as other natriuretic hormones, should be determined during and after spaceflight. Alterations in body fluid volume and blood electrolyte concentrations during spaceflight have important consequences for readaptation to the 1-G environment. The current assessment of fluid and electrolyte status during weightlessness and at landing and our still incomplete understanding of the processes of adaptation to weightlessness and readaptation to Earths gravity have resulted in the development of countermeasures that are only partly successful in reducing the postflight orthostatic intolerance experienced by astronauts and cosmonauts. More complete knowledge of these processes can be expected to produce countermeasures that are even more successful, as well as expand our comprehension of the range of adaptability of human physiologic processes.


Acta Astronautica | 1988

The endocrine system in space flight

Carolyn S. Leach; Philip C. Johnson; Nitza M. Cintron

Hormones are important effectors of the bodys response to microgravity in the areas of fluid and electrolyte metabolism, erythropoiesis, and calcium metabolism. For many years antidiuretic hormone, cortisol and aldosterone have been considered the hormones most important for regulation of body fluid volume and blood levels of electrolytes, but they cannot account totally for losses of fluid and electrolytes during space flight. We have now measured atrial natriuretic factor (ANF), a hormone recently shown to regulate sodium and water excretion, in blood specimens obtained during flight. After 30 or 42 h of weightlessness, mean ANF was elevated. After 175 or 180 h, ANF had decreased by 59%, and it changed little between that time and soon after landing. There is probably an increase in ANF early inflight associated with the fluid shift, followed by a compensatory decrease in blood volume. Increased renal blood flow may cause the later ANF decrease. Erythropoietin (Ep), a hormone involved in the control of red blood cell production, was measured in blood samples taken during the first Spacelab mission and was significantly decreased on the second day of flight, suggesting also an increase in renal blood flow. Spacelab-2 investigators report that the active vitamin D metabolite 1 alpha, 25-dihydroxyvitamin D3 increased early in the flight, indicating that a stimulus for increased bone resorption occurs by 30 h after launch.


The Journal of Clinical Pharmacology | 1991

Metabolic changes observed in astronauts

Carolyn S. Leach; Nitza M. Cintron; Jane M. Krauhs

Study of metabolic alterations that occur during space flight can provide insight into mechanisms of physiologic regulation. Results of medical experiments with astronauts reveal rapid loss of volume (2 L) from the legs and a transient early increase in left ventricular volume index. These findings indicate that, during space flight, fluid is redistributed from the legs toward the head. In about 2 days, total body water decreases 2 to 3%. Increased levels of plasma renin activity and antidiuretic hormone while blood sodium and plasma volume are reduced suggest that space flight‐associated factors are influencing the regulatory systems. In addition to fluid and electrolyte loss, Skylab astronauts lost an estimated 0.3 kg of protein. Endocrine factors, including increased cortisol and thyroxine and decreased insulin, are favorable for protein catabolism. The body appears to adapt to weightlessness at some physiologic cost. Readaptation to Earths gravity at landing becomes another physiologic challenge.


The Journal of Clinical Pharmacology | 1991

Changes in Total Body Water During Spaceflight

Carolyn S. Leach; L. D. Inners; John B. Charles

This experiment represents the first time that it has been possible to measure a body fluid compartment by direct means during spaceflight. Based on the results observed in the five crewmen in this study, it is concluded that TBW decreases by 3.4% after 1 to 3 days of exposure to microgravity in the Space Shuttle. Some individuals appear to undergo this decrease within 24 hours. This effect may be enhanced by decreased water intake due to nausea associated with SMS.


The Journal of Clinical Pharmacology | 1994

Short‐Term Space Flight on Nitrogenous Compounds, Lipoproteins, and Serum Proteins

Carolyn S. Leach; Helen W. Lane; Jane M. Krauhs

Biochemical variables in blood were measured in venous blood samples from 38 to 72 Space Shuttle astronauts before and immediately after flights of 2 to 11 days. Mean pre‐ and postflight values were compared using the paired t‐test or the Wilcoxon signed‐rank test. The largest change in serum enzymes was a 21% increase (P = .0014) in γ‐glutamyltranspeptidase, which may have been related to stress. The median value of apolipoprotein (apo) A‐I decreased from 152 to 127 mg/dL (P > .0001), but the change in apo B (77 to 73 mg/dL) was not statistically significant, and the mean apo A‐I/apo B ratio remained well above 1.5. A decrease in dietary fat and cholesterol intake during shuttle missions may have been a cause of the change in apo A‐I. Twelve of the 16 nonenzyme serum proteins measured were significantly elevated (P > .05), possibly because of hemoconcentration and increased protein catabolism. The 56% increase in haptoglobin may be related to release of suppressed erythropoiesis at landing.


Journal of Applied Physiology | 1996

Regulation of body fluid compartments during short-term spaceflight

Carolyn S. Leach; C. P. Alfrey; W. N. Suki; J. I. Leonard; P. C. Rambaut; L. D. Inners; S. M. Smith; H. W. Lane; Jane M. Krauhs


The Journal of Clinical Endocrinology and Metabolism | 1998

Collagen Cross-Link Excretion during Space Flight and Bed Rest

Scott M. Smith; Jeannie L. Nillen; Adrian LeBlanc; Allan Lipton; Laurence M. Demers; Helen W. Lane; Carolyn S. Leach


Archive | 1977

Biochemical responses of the Skylab crewmen: An overview

Carolyn S. Leach; P. C. Rambaut


Aviation, Space, and Environmental Medicine | 1976

Mineral and nitrogen balance study observations - The second manned Skylab mission

G. D. Whedon; J. Reid; L. Lutwak; P. C. Rambaut; M. W. Whittle; M. C. Smith; Carolyn S. Leach; C. R. Stadler; D. D. Sanford

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Philip C. Johnson

Baylor College of Medicine

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Scott M. Smith

United States Department of Agriculture

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Adrian LeBlanc

Universities Space Research Association

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Allan Lipton

Penn State Milton S. Hershey Medical Center

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G.D. Whedon

University of California

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Laurence M. Demers

Pennsylvania State University

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P.C. Rambaut

University of California

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