Carolyn Watts

Health Care Transitions Among Youth With Disabilities or Special Health Care Needs: An Ecological Approach

This literature review of 46 articles uses the ecological model as a framework for organizing concepts and themes related to health care transition among youth with disabilities or special health care needs (SHCN). Transition involves interactions in immediate and distal environmental systems. Important interactions in immediate environments include those with family members, health care providers, and peers. Activities in distal systems include policies at the governmental and health system levels. The ecological model can help researchers and practitioners to design experimental interventions in multiple settings that ensure smooth transitions and support the well-being of youth with disabilities or SHCN.

Pharmacogenomic testing to prevent aminoglycoside-induced hearing loss in cystic fibrosis patients: potential impact on clinical, patient, and economic outcomes

Background: Aminoglycosides are commonly used in cystic fibrosis patients to treat Pseudomonas aeruginosa respiratory infections. Aminoglycoside-induced hearing loss may occur in 1%–15% of patients with cystic fibrosis, ranging from mild to severe. Recently, a genetic test to identify patients with a mitochondrial mutation (A1555G) that may predispose patients to this adverse event has become available. Although the A1555G variant is very rare, it seems to confer a high risk of severe hearing loss in patients exposed to aminoglycosides.Objective: The objective was to evaluate the potential clinical, patient, and economic outcomes associated with the use of A1555G testing in a cystic fibrosis population, and explore data gaps and uncertainty in its clinical implementation.Methods: We developed a decision-analytic model to evaluate a hypothetical cohort of patients with cystic fibrosis from a societal perspective. Clinical and economic data were derived primarily from a critical literature review. The incidence of aminoglycoside-induced severe hearing loss, quality-adjusted life-years, and total health care costs were evaluated. Sensitivity analyses were conducted to evaluate uncertainty in our results.Results: In the base-case analysis, A1555G testing decreased the risk of severe aminoglycoside-induced hearing loss by 0.12% in the cystic fibrosis population. The discounted incremental cost per quality-adjusted life-years gained was

On the Measurement of Hospital Case Mix

79,300, but varied widely from

A current reappraisal of berry’s hospital typology

33,000 to testing being dominated by the no testing strategy (higher costs and lower quality-adjusted life-years with testing) in sensitivity analyses. If avoidance of aminoglycosides in patients testing positive leads to an absolute increase in the lifetime risk of death from Pseudomonas infection of 0.8% or greater, A1555G testing would lead to a decrease in quality-adjusted life-years.Conclusions: The results of our analysis suggest that there are significant data gaps and uncertainty in the outcomes with A1555G testing, but it is not likely cost-effective, and could lead to worse patient outcomes due to avoidance of first-line therapy in the >95% of patients who are false-positives. Additional research is needed before pharmacogenetic testing for the A1555G mitochondrial mutation can be recommended, even in a population with a high likelihood of exposure to aminoglycosides.

Retention in a Breast Cancer Risk Information Trial: Motivations of a Population-Based Sample of Women

This article discusses a number of issues related to the measurement of hospital diagnostic case mix. We initially examine a number of previous attempts to measure case mix based on surrogate measures (e.g., facilities and services) and information from predetermined discharge-classification systems. Since a number of researchers have attempted to reduce diagnostic classification data into a single-valued (i.e., scalar) case mix index, we then discuss a number of concepts and assumptions implicit in the construction of such indices. Among these assumptions is the property of functional homogeneity; this property and a methodology based on Q-type factor analysis for testing for the presence of this property are defined. In order to illustrate the use of the methodology, it is applied to data from 153 hospitals in downstate New York.

Cost Effectiveness Analysis Some Problems of Implementation

In an earlier article, Berry1 published the results of a study that examined possible relationships among hospital facilities and services. In general, Berry found that hospitals behaved in a reasonably consistent fashion; that is, hospitals added facilities and services in a well-defined order, and these facilities and services were added in distinct groups. Berry defined five such groups and hypothesized that each group represents an increasing level of case-mix complexity. Given the current interest in using Berrys results to measure hospital case mix, this study attempted to replicate Berrys results using recent data from the American Hospital Association. Using a number of statistical methodologies (including cluster analysis and Guttman scale analysis), we found that hospitals continue to add facilities and services in a well-defined order (although this order contains some notable differences from the order found by Berry). However, our results indicate that hospitals no longer add facilities and services in well-defined groups but in a more continuous fashion. Thus, it would appear that hospitals have become more differentiated.

Health insurance regain after a spell of uninsurance: a longitudinal comparison of youth with and without disabilities transitioning into adulthood.

A better understanding of factors influencing retention in breast cancer risk education and prevention programs can improve the design and effectiveness of such programs. Such information may also be useful to researchers seeking to maximize full retention in research trials involving low risk and low perceived benefit by the participants. These data are from a population-based study of 481 women from the Seattle, Washington, area, with diverse levels of breast cancer risk. This study sought to describe motivations for retention, to relate motivation variables to demographic characteristics, and to evaluate predictors of retention. Increasing age predicted study assessment completion, and both cancer worry and White ethnicity predicted intervention retention.

Opportunities for Public Health Genetics Trainees: Results of an Employer/Workplace Survey

Cost benefit analyses in the health sector frequently deal with situations in which the money value of the benefits is either difficult or impossible to measure. This paper asserts that the use of cost effectiveness analysis as a means of escaping the need to place a dollar value on benefits does not escape the need for appropriately discounting these benefits when they accrue in different periods over time. The choice of an appropriate discount rate is discussed, and the benefits of elective hysterectomy are used to demonstrate that a serious bias can result from ignoring the need for discounting.

Utilization trends of genetic clinics excluding prenatal services in Washington State, 1995–2004

PURPOSE To examine insurance regain among youth with no, nonsevere, and severe disabilities. METHODS The data source for this study was the Survey of Income and Program Participation 2001. We examined insurance regain among youth with no, nonsevere, and severe disabilities between the ages of 15 and 25 using a longitudinal design. Kaplan-Meier survival functions provided estimates of uninsurance spell durations measured in waves, or 4-month intervals. We conducted a discrete time survival analysis adjusting for personal characteristics. RESULTS This study includes 1,310 youth who entered the SIPP with insurance and became uninsured. 985 youth (75%) regained insurance. Based on SIPP waves, median duration of uninsurance was two waves (between 5 and 8 months) for youth with severe disabilities and three waves (between 9 and 12 months) for youth with nonsevere disability. Youth with nonsevere disabilities had decreased odds of regaining health insurance compared to youth without disabilities (odds ratio .73; 95% confidence interval: .57, .92; p=.01). CONCLUSIONS Youth with severe disabilities and youth without disabilities had similar odds of and durations to insurance regain. In contrast, youth with nonsevere disabilities had lower odds of regaining insurance and experienced longer durations of uninsurance compared to peers without disabilities. We recommend additional research into the implications of Medicaid eligibility pathways and employment barriers for youth with nonsevere disabilities.

The flight of physicians from West Africa: Views of African physicians and implications for policy

Objective: To conduct the first employer/workplace survey identifying employment opportunities for graduates of programs with training in public health genetics in the USA, and to determine whether employment opportunities will increase in coming years. Methods: Six public health genetics training competencies were developed. A survey about workplace and employment opportunities was then conducted with mailings to (1) departments in schools of public health and departments of preventive medicine, (2) local and regional public health officials, (3) insurance companies and health management organizations (HMOs), and (4) biotechnology and pharmaceutical companies. Results: A total of 196 surveys were returned among 1,464 that were mailed. Response rates varied from 5.8 to 46.5% among the target groups. The percent of responding organizations currently employing individuals with skills in genetics ranged from 20 to 62%. The percent currently employing individuals with skills in public health ranged from 39 to 96%. Training opportunities such as internships or practicum experiences are reported for one-third of respondents. For all of the competencies, approximately half of survey respondents who rated the competency important or very important already employ individuals with public health genetics skills. Similarly, at least a quarter of survey respondents who rated the competency important or very important plan to hire individuals with that skill in the next 5 years. Overall, approximately 40% of those surveyed are planning to hire individuals with competencies in public health genetics in the next 5 years. Conclusion: Employment opportunities already exist and new positions are becoming available in schools of public health and departments of preventive medicine, departments of public health, insurance companies and HMOs for professionals with public health genetics training. Based on our survey findings, skills and training in public health genetics are important in the workplace.