Carrie L. Ernst

Antidepressant properties of anticonvulsant drugs for bipolar disorder.

A growing number of anticonvulsant drugs are receiving attention as possible mood stabilizers. This attention is based mainly on the assumption that the antimanic efficacy of anticonvulsants makes them suitable as mood stabilizers. However, their antidepressant properties have received less scrutiny. In this review, current evidence concerning the acute and prophylactic efficacy of divalproex, carbamazepine, gabapentin, lamotrigine, and topiramate in bipolar depression is evaluated. Clinical outcome data are considered, together with limitations of existing studies and the concept of unmet clinical needs. Findings in placebo-controlled trials suggest an acute and prophylactic antidepressant effect with lamotrigine monotherapy and more modest antidepressant benefits with other agents administered as monotherapies. Results of published studies are considered with respect to the conceptualization of mood stabilization as arising from antimanic and antidepressant efficacy in bipolar disorder.

Clinical correlates of childhood and adolescent adjustment in adult patients with bipolar disorder.

Impaired psychosocial functioning has been well documented in bipolar disorder, although there is little information linking premorbid adjustment with adult functional outcome. Childhood and adolescent functioning in school, peer relations, and personal interests was evaluated by standardized interviews with 56 adult-onset DSM-IV bipolar I (N = 46), II (N = 7), or not otherwise specified (N = 3) patients, with collaboration by collateral historians, and assessed relative to current work functioning and overall illness features. Poor childhood or adolescent adjustment was associated with subsequent alcohol or drug abuse or dependence (p < .05), insidious onset of bipolar disorder (p < .02), and increased suicide attempts (p <.02). Poor adjustment in childhood was related to the lifetime development of rapid cycling. Poor premorbid adjustment may be linked with the potential to develop substance abuse comorbidity and an increased risk for suicide attempts and rapid cycling in bipolar patients. The prognostic significance of maladaptive childhood or adolescent behaviors may bear directly on clinical components of outcome in bipolar disorder.

Recommendations for Training Psychiatry Residents in Psychosomatic Medicine

BACKGROUND The Accreditation Council of Graduate Medical Education (ACGME) mandates that residents in psychiatry training programs learn to provide psychiatric consultation to other medical and surgical services. The ACGME, however, offers little information to instruct academic faculty and institutions to what constitutes a quality educational experience in psychosomatic medicine/consultation-liaison psychiatry for the resident trainee. METHODS These recommendations were developed through a collaborative process between educators in C-L psychiatry and members of the Academy of Psychosomatic Medicines Residency Education Subcommittee. RESULTS This manuscript provides a broad framework for what constitutes a well-rounded clinical and academic resident rotation on psychiatric consultation-liaison services. A rotation that is viewed positively by residents is important as it likely provides a foundation for a growing interest in Psychosomatic Medicine and the development of future fellows and subspecialty trained physicians.

Core Concepts Involving Adverse Psychotropic Drug Effects: Assessment, Implications, and Management.

Adverse effects from psychiatric drugs can profoundly influence treatment adherence and outcomes. Good care involves addressing adverse effects no differently than any other component of treatment. Knowledge about adverse effect assessment and management fosters a proper context that helps clinicians not sacrifice a drugs potential therapeutic benefits because of greater concerns about its tolerability. This article provides an overview of basic concepts related to the assessment and management of suspected adverse effects from psychotropic drugs. Key points are discussed regarding clinical, pharmacogenetic, pharmacokinetic, and pharmacodynamic risk factors for treatment-emergent adverse effects, alongside recommendations for their systematic assessment.