Carsten Gundlach
Technical University of Denmark
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Carsten Gundlach.
Journal of Controlled Release | 2017
Chiara Mazzoni; Fabio Tentor; Sophie Susanna Strindberg Andersen; Line Hagner Nielsen; Stephan Sylvest Keller; Tommy Sonne Alstrøm; Carsten Gundlach; Anette Müllertz; Paolo Marizza; Anja Boisen
&NA; This work explores the potential of polymeric micrometer sized devices (microcontainers) as oral drug delivery systems (DDS). Arrays of detachable microcontainers (D‐MCs) were fabricated on a sacrificial layer to improve the handling and facilitate the collection of individual D‐MCs. A model drug, ketoprofen, was loaded into the microcontainers using supercritical CO2 impregnation, followed by deposition of an enteric coating to protect the drug from the harsh gastric environment and to provide a fast release in the intestine. In vitro, in vivo and ex vivo studies were performed to assess the viability of the D‐MCs as oral DDS. D‐MCs improved the relative oral bioavailability by 180% within 4 h, and increased the absorption rate by 2.4 times compared to the control. This work represents a significant step forward in the translation of these devices from laboratory to clinic. Graphical abstract Figure. No caption available.
Journal of Materials Science | 2018
Lucie Chapelle; Allan Lyckegaard; Yukihiro Kusano; Carsten Gundlach; Mathilde Rosendahl Foldschack; Dorthe Lybye
A method to determine the orientation and diameter distributions of mineral wool fibre networks using X-ray tomography and image analysis is presented. The method is applied to two different types of mineral wool: glass wool and stone wool. The orientation information is obtained from the computation of the structure tensor, and the diameter is estimated by applying a greyscale granulometry. The results of the image analysis indicate the two types of fibres are distributed in a 2D planar arrangement with the glass wool fibres showing a higher degree of planarity than the stone wool fibres. The orientation information is included in an analytical model based on a Euler–Bernoulli beam approximation. The model enables prediction of the transverse stiffness. It is indicated that the glass wool transverse stiffness is lower than the stone wool transverse stiffness. Comparison with experimental results confirms the assumption that the underlying deformation mechanism of mineral wool is the bending of fibre segments between bonds.
Materials Science Forum | 2004
A.W. Larsen; Carsten Gundlach; Henning Friis Poulsen; L. Margulies; Q. Xing; Dorte Juul Jensen
A new method for in-situ studies of nucleation in bulk metals based on high energy synchrotron radiation is presented. Copper samples cold rolled 20% are investigated. The crystallographic orientations near triple junctions are characterized using non-destructive 3DXRD microscopy before, during, and after annealing for 1 hour at 290°C. This method allows in-situ identification of new nuclei and the deformed material, which spawns the nuclei. Also, since data is acquired during annealing nucleation kinetics can be studied.
Journal of Imaging | 2018
Anna Fedrigo; Kasper Marstal; Christian Koch; Vedrana Andersen Dahl; Anders Bjorholm Dahl; Mark Lyksborg; Carsten Gundlach; F. Ott; Markus Strobl
X-ray and neutron tomography are applied as a bi-modal approach for the 3D characterisation of a Monturaqui impactite formed by shock metamorphism during the impact of an iron meteorite with the target rocks in the Monturaqui crater (Chile). The particular impactite exhibits structural heterogeneities on many length scales: its composition is dominated by silicate-based glassy and crystalline materials with voids and Fe/Ni-metal and oxihydroxides particles generally smaller than 1 mm in diameter. The non-destructive investigation allowed us to apply a novel bi-modal imaging approach that provides a more detailed and quantitative understanding of the structural and chemical composition compared to standard single mode imaging methods, as X-ray and neutron interaction with matter results in different attenuation coefficients with a non-linear relation. The X-ray and neutron data sets have been registered, and used for material segmentation, porosity and metallic content characterization. The bimodal data enabled the segmentation of a large number of different materials, their morphology as well as distribution in the specimen including the quantification of volume fractions. The 3D data revealed an evaporite type of material in the impactite not noticed in previous studies. The present study is exemplary in demonstrating the potential for non-destructive characterisation of key features of complex multi-phase objects such as impactites.
Applied Optics | 2017
Jonathan Dyssel Stets; Alessandro Dal Corso; Jannik Boll Nielsen; Rasmus Ahrenkiel Lyngby; Sebastian Hoppe Nesgaard Jensen; Jakob Wilm; Mads Emil Brix Doest; Carsten Gundlach; Eythor Runar Eiriksson; Knut Conradsen; Anders Bjorholm Dahl; Jakob Andreas Bærentzen; Jeppe Revall Frisvad; Henrik Aanæs
Transparent objects require acquisition modalities that are very different from the ones used for objects with more diffuse reflectance properties. Digitizing a scene where objects must be acquired with different modalities requires scene reassembly after reconstruction of the object surfaces. This reassembly of a scene that was picked apart for scanning seems unexplored. We contribute with a multimodal digitization pipeline for scenes that require this step of reassembly. Our pipeline includes measurement of bidirectional reflectance distribution functions and high dynamic range imaging of the lighting environment. This enables pixelwise comparison of photographs of the real scene with renderings of the digital version of the scene. Such quantitative evaluation is useful for verifying acquired material appearance and reconstructed surface geometry, which is an important aspect of digital content creation. It is also useful for identifying and improving issues in the different steps of the pipeline. In this work, we use it to improve reconstruction, apply analysis by synthesis to estimate optical properties, and to develop our method for scene reassembly.
Materials Science Forum | 2004
Carsten Gundlach; Wolfgang Pantleon; E.M. Lauridsen; L. Margulies; R.D. Doherty; Henning Friis Poulsen
A method for in-situ studies of the dynamics of individual embedded subgrains during recovery is introduced. The method is an extension of 3DXRD principles for studies of grain dynamics in connection with recrystallisation. It is limited to studies of foils with a sample thickness of 10-100 subgrains due to diffraction spot overlap. The volume evolution during recovery (annealing at 300°C for 181 minutes) of nine individual subgrains in a deformed sample (38% cold rolled Aluminium) is presented.
ASME 2004 International Mechanical Engineering Congress and Exposition | 2004
S.F. Nielsen; Carsten Gundlach; E.M. Lauridsen; R. V. Martins; Henning Friis Poulsen; S. Schmidt; D. Juul Jensen
By Three Dimensional X-ray Diffraction (3DXRD) microscopy it is possible to characterize microstructures non-destructively in 3 dimensions. The measurements are furthermore typically so fast that dynamics may be monitored in-situ, giving also the 4th dimension, namely the time. The 3DXRD technique is based on diffraction of high energy x-rays from third generation synchrotron sources. In the present paper the 3DXRD technique is described and it’s potentials are illustrated by examples relating to elastic and plastic strains, recovery, recrystallization and grain growth.Copyright
Science | 2004
S. Schmidt; S.F. Nielsen; Carsten Gundlach; L. Margulies; X. Huang; D. Juul Jensen
Science | 2006
Bo Jakobsen; Henning Friis Poulsen; Ulrich Lienert; Jonathan Almer; S. D. Shastri; Henning Osholm Sørensen; Carsten Gundlach; Wolfgang Pantleon
Scripta Materialia | 2004
Carsten Gundlach; Wolfgang Pantleon; E.M. Lauridsen; L. Margulies; Roger D. Doherty; Henning Friis Poulsen