Cassius Mcallister Tucker
Pfizer
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Featured researches published by Cassius Mcallister Tucker.
Javma-journal of The American Veterinary Medical Association | 2009
John A. Ellis; Sheryl P. Gow; Noriko Goji; Clinton Jones; Aspen Workman; Gail Henderson; Carrie Rhodes; Glenn Alaniz; Todd R. Meinert; Cassius Mcallister Tucker
OBJECTIVE To determine whether a combination viral vaccine containing a modified-live bovine herpesvirus-1 (BHV-1) would protect calves from infection with virulent field strains of BHV-1 for weeks or months after vaccination. DESIGN Randomized controlled trial, performed in 2 replicates. ANIMALS 63 weaned 4- to 6-month-old crossbred beef calves seronegative for antibody against BHV-1. PROCEDURES Calves were randomly allocated to 1 of 2 treatment groups. Control calves (n = 10/replicate) received a combination modified-live mixed viral vaccine without BHV-1, and treatment calves (20 and 23/replicate) received a combination modified-live mixed viral vaccine containing BHV-1. Each group was challenged via aerosol with 1 of 2 field strains of BHV-1, 30 days after vaccination in replicate 1 and 97 days after vaccination in replicate 2. After challenge, calves were commingled in 1 drylot pen. Clinical signs, immune responses, and nasal shedding of virus were monitored for 10 days after challenge, after which the calves were euthanatized and tracheal lesions were assessed. RESULTS Vaccination stimulated production of BHV-1-specific IgG antibody that cross-neutralized several field and laboratory strains of BHV-1. Challenge with both field strains of BHV-1 resulted in moderate to severe respiratory tract disease in control calves. Treatment calves had significantly fewer signs of clinical disease, shed less BHV-1, had less or no weight loss after challenge, and had fewer tracheal lesions than control calves for at least 97 days after vaccination. CONCLUSIONS AND CLINICAL RELEVANCE Administration of the combination modified-live BHV-1 vaccine yielded significant disease-sparing effects in calves experimentally infected with virulent field strains of BHV-1.
Javma-journal of The American Veterinary Medical Association | 2006
Martin D. Ficken; Michael A. Ellsworth; Cassius Mcallister Tucker; Victor S. Cortese
Archive | 2003
Michael A. Ellsworth; Martin D. Ficken; Brian James Fergen; Cassius Mcallister Tucker
Archive | 2005
Joseph Claude Frantz; Thomas Jack Newby; Cassius Mcallister Tucker
Archive | 2006
David E. Lowery; Sing Rong; Paul Mark Guimond; Paula Munns Clare; Cassius Mcallister Tucker; Thomas Jack Newby
Archive | 2004
Michael A. Ellsworth; Martin D. Ficken; Brian James Fergen; Cassius Mcallister Tucker
Archive | 2013
David E. Lowery; アール ロウェリ デイヴィッド; Sing Rong; ロング シング; Paul Mark Guimond; マーク グイモンド ポール; Paula Munns Clare; ムンス クレア ポーラ; Cassius Mcallister Tucker; マックアリスター タッカー カシウス; Thomas Jack Newby; ジャック ニュービー トーマス
Archive | 2006
David E. Lowery; Sing Rong; Paul Mark Guimond; Paula Munns Clare; Cassius Mcallister Tucker; Thomas Jack Newbuy
Archive | 2006
Paula Munns Clare; Paul Mark Guimond; David E. Lowery; Thomas Jack Newby; Sing Rong; Cassius Mcallister Tucker
Archive | 2006
Paula Munns Clare; Paul Mark Guimond; David E. Lowery; Thomas Jack Newby; Sing Rong; Cassius Mcallister Tucker