Catherine Foulon
Lille University of Science and Technology
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Publication
Featured researches published by Catherine Foulon.
Journal of Chromatography A | 2001
Emmanuelle Belloli; Catherine Foulon; Said Yous; Marie-Pierre Vaccher; Jean-Paul Bonte; Claude Vaccher
Analytical HPLC methods using derivatized cellulose chiral stationary phases were developed for the direct separation of the stereoisomers of disubstituted tetralin derivatives with two chiral centers, new agonist and antagonist ligands for melatonin receptors. The separations were made using normal-phase methodology with a mobile phase consisting of n-hexane-alcohol (methanol, ethanol, 1-propanol or 2-propanol) in various proportions, and a silica-based cellulose tris-3,5-dimethylphenylcarbamate (Chiralcel OD-H), or tris-methylbenzoate (Chiralcel OJ). The effects of concentration of various aliphatic alcohols in the mobile phase were studied. A better separation was achieved on cellulose carbamate phase compared with the cellulose ester phase. The effects of structural features of the solutes on the discrimination between the stereoisomers were examined. Baseline separation (Rs>1.5) was easily obtained in many cases.
Journal of Chromatography B | 2008
Jean-François Goossens; S. Roux; David Egron; Christian Périgaud; Jean-Paul Bonte; Claude Vaccher; Catherine Foulon
Separations of five diastereoisomers of nucleoside phosphoramidate derivatives (pronucleotides) were performed by both HPLC method using derivatized cellulose and amylose chiral stationary phases and CE method using anionic cyclodextrins added in the background electrolyte (BGE). An optimal baseline separation (Rs > 1.5) was readily obtained with all silica-based celluloses and amyloses using in a normal-phase methodology. Capillary electrophoresis was used as an alternative technique to HPLC for the separation of pronucleotides. The diastereoisomers were fully resolved with sulfated cyclodextrins at both BGE pH (2.5 and 6.2). Limits of detection and limits of quantification, calculated for both methods, are up to 200 times higher in CE separations than in HPLC separations. The analytical HPLC method was then applied in a preliminary study for the pronucleotide 1 quantification in cellular extract.
Chromatographia | 2000
Emmanuelle Belloli; Catherine Foulon; Said Yous; Jean-Paul Bonte; Claude Vaccher
SummaryFive methoxytetrahydronaphthalene derivatives, new agonist and antagonist ligands for melatonin receptors, were resolved into their diastereomers by analytical HPLC methods using derivatized amylose, chiral stationary phases. Separation was by using normal phase methodology with a mobile phase ofn-hexane-alcohol (ethanol or 2-propanol) and a silica-based amylose tris-(S)-1-phenylethylcarbamate (Chiralpak AS), or tris-3,5-dimethylphenylcarbamate (Chiralpak AD). The effects of structural variation in the solutes were noted. Baseline separation was easily obtained in many cases.
Electrophoresis | 2004
Catherine Foulon; Cécile Danel; Marie-Pierre Vaccher; Jean-Paul Bonte; Claude Vaccher; Jean-François Goossens
European Journal of Pharmaceutical Sciences | 2007
Catherine Foulon; N. Duhal; B. Lacroix-Callens; Claude Vaccher; Jean-Paul Bonte; Jean-François Goossens
Journal of Chromatography A | 2004
Catherine Foulon; Cécile Danel; Claude Vaccher; Said Yous; Jean-Paul Bonte; Jean-François Goossens
Electrophoresis | 2005
Cécile Danel; Emmanuelle Lipka; Jean-Paul Bonte; Jean-François Goossens; Claude Vaccher; Catherine Foulon
Electrophoresis | 2005
Marie-Pierre Vaccher; Emmanuelle Lipka; Jean-Paul Bonte; Catherine Foulon; Jean-François Goossens; Claude Vaccher
Tetrahedron-asymmetry | 2006
Cécile Danel; Nathalie Azaroual; Catherine Foulon; Jean-François Goossens; Gaston Vermeersch; Jean-Paul Bonte; Claude Vaccher
Chromatographia | 2004
Jean-François Goossens; Catherine Foulon; C. Bailly; D.C.H. Bigg; Jean-Paul Bonte; Claude Vaccher