Catherine L. McCarthy
Nuffield Orthopaedic Centre
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Publication
Featured researches published by Catherine L. McCarthy.
Skeletal Radiology | 2004
Catherine L. McCarthy; Eugene G. McNally
This review presents a comprehensive illustrated overview of the wide variety of cystic lesions around the knee. The aetiology, clinical presentation, MRI appearances and differential diagnosis are discussed. Bursae include those related to the patella as well as pes anserine, tibial collateral ligament, semimembranosus–tibial collateral ligament, iliotibial and fibular collateral ligament–biceps femoris. The anatomical extension, imaging features and clinical significance of meniscal cysts are illustrated. Review of ganglia includes intra-articular, extra-articular, intraosseous and periosteal ganglia, highlighting imaging findings and differential diagnoses. The relationship between proximal tibiofibular joint cysts and intraneural peroneal nerve ganglia is discussed. Intraosseous cystic lesions, including insertional and degenerative cysts, as well as lesions mimicking cysts of the knee are described and illustrated. Knowledge of the location, characteristic appearance and distinguishing features of cystic masses around the knee as well as potential imaging pitfalls such as normal anatomical recesses and atypical cyst contents on MR imaging aids in allowing a specific diagnosis to be made. This will prevent unnecessary additional investigations and determine whether intra-articular surgery or conservative management is appropriate.
Skeletal Radiology | 2004
Christopher. S. J. Fang; Catherine L. McCarthy; Eugene G. McNally
Baker’s cysts are fluid distensions of the gastrocnemius-semimembranosus bursa and are the most common cystic lesion around the knee. Typically cysts enlarge along intermuscular planes around the knee. We report three cases in which the expanding cyst did not respect these planes and dissected along an intramuscular route as confirmed by MR imaging. Such behaviour by Baker’s cysts is hitherto unreported in the literature. Possible mechanisms to account for this phenomenon are discussed.
Skeletal Radiology | 2006
Abigail Smithard; Michael J. Lamyman; Catherine L. McCarthy; C. L. M. H. Gibbons; Paul Cooke; N A Athanasou
We report on a case of a 36-year-old lady who presented with large, painful soft-tissue swellings of both Achilles tendons. MRI demonstrated fusiform enlargement involving the Achilles tendons bilaterally. The tendons returned heterogeneous signal intensity characterised by a diffuse reticulated appearance. The right tendon mass was treated with a wide marginal excision and Achilles tendon reconstruction. The histology confirmed Achilles tendon xanthoma. Further metabolic investigation revealed the patient to have a rare autosomal recessive condition called cerebrotendinous xanthomatosis (CTX). Her brother was also affected. CTX is easily treatable if diagnosed early, and should be suspected in patients presenting with bilateral Achilles tendon xanthomas and normal plasma lipid levels.
Skeletal Radiology | 2017
Catherine L. McCarthy; Yoshinobu Uchihara; Marianna Vlychou; George Grammatopoulos; Nicholas A. Athanasou
A number of previous studies have reported a potential risk of malignancy, particularly hematological malignancy, developing in patients receiving a metal-on-metal (MoM) hip replacement. We report a case of malignant lymphoma that arose in a patient who had an MoM hip arthroplasty complicated by development of a pseudotumour. The tumour was a B cell follicular lymphoma that involved lymph nodes and bone. Metal ions are known to have a genotoxic effect on lymphoid cells. Although epidemiological studies have not established that there is an increased risk of lymphoma associated with MoM implants, only a relatively short time period has elapsed since re-introduction of this type of implant and long-term follow-up of patients with MoM implants is indicated.
Skeletal Radiology | 2017
Richard Craig; Marianna Vlychou; Catherine L. McCarthy; C. L. M. H. Gibbons; Nicholas A. Athanasou
Pseudotumours are well recognised as a complication of metal-on-metal hip arthroplasties and are thought to develop on the basis of an innate and adaptive immune response to cobalt-chrome (Co-Cr) wear particles. We report a case of a large pseudotumour that developed following a knee endoprosthetic replacement (EPR) undertaken for Ewing sarcoma. The lesion contained necrotic and degenerate connective tissue in which there were numerous scattered metal wear-containing macrophages, eosinophil polymorphs, lymphocytes, plasma cells and aseptic lymphocyte-dominated vascular-associated lesion-like lymphoid aggregates. Metal ion levels were elevated. No evidence of infection or tumour was noted and it was concluded that the lesion was most likely an inflammatory pseudotumour developing on the basis of an innate and adaptive immune response to components of Co-Cr metal wear derived from the knee EPR.
Skeletal Radiology | 2008
Catherine L. McCarthy; D. J. Wilson; T. P. Coltman
Skeletal Radiology | 2016
Catherine L. McCarthy; W. J. Anderson; Marianna Vlychou; Y. Inagaki; Duncan Whitwell; C. L. M. H. Gibbons; N. A. Athanasou
Clinical sarcoma research | 2016
Catherine L. McCarthy; Monika Hofer; Marianna Vlychou; Robar Khundkar; Paul Critchley; Simon Cudlip; Olaf Ansorge; N.A. Athanasou
Clinical sarcoma research | 2018
G L Tiemeier; J M Brown; S E Pratap; Catherine L. McCarthy; A Kastrenopoulou; Kevin M. Bradley; S Wilson; Z Orosz; Gibbons Clmh.; U. Oppermann; Nicholas A. Athanasou
British Journal of Hospital Medicine | 2018
George Grammatopoulos; Catherine L. McCarthy; Alberto Carli; Wade Gofton