Cathy Holding

SAGE is better than dbEST

SummaryThe more data compiled from serial analysis of gene expression experiments, the more novel genes are likely to be found, in contrast to the situation with expressed sequence tags.

Differentiation is death

SummaryThe apoptosis signaling molecule caspase 3 is also required for differentiation in myoblasts

Autosome inactivation by ectopic XIST in differentiated cells

SummaryHuman XIST, when integrated into autosomes in a fully differentiated adult human tumor cell line, caused localized chromosome inactivation, counter to all previous concepts of a specific narrow window of opportunity for X-inactivation

Xist comparative genomics

The primary sequence of Xist seems not to be important for Xist to function in X-chromosome inactivation.

SRY is a target of WT1

The SRY gene has been shown to be a direct transcriptional target of the WT1 transcription factor.

A new histone variant: macroH2A2

MacroH2A1 and macroH2A2 are two different histone loci with probable common genetic ancestry.

Knowing your head from your tail

Information for establishing the anterior-posterior axis of a mammalian embryo is contained in the fertilized egg.

BRCA1 linked with Fanconi anemia

Fanconi anemia and breast cancer have been shown to share a common DNA repair pathway.

Human TSIX- an evolutionary relic?

Analysis of the human TSIX transcript shows it to be a truncated and probably non-functional evolutionary relic