Cedric A. Quick

Relationship between Condylomata and Laryngeal Papillomata: Clinical and Molecular Virological Evidence

In a survey of 49 papilloma patients accurate maternal condyloma history was obtained in 31 instances and of these, 21 were positive for the presence of condyloma during pregnancy or parturition. Molecular virological studies indicate that positive hybridization could be demonstrated to human papilloma virus 2 in both laryngeal papilloma and condyloma by the Southern blot technique. Immunoperoxidase staining illustrated the presence of virus-related particles only near the surface of the mucous membrane papilloma, which is in contrast to the definite staining of the stratum granulosum and stratum corneum of verrucae. Collectively this provides convincing evidence for an etiological relationship between condyloma acuminata and some laryngeal papillomata. The highly contagious nature of human papilloma virus infection is discussed and the possibility of cesarian section in the presence of active condyloma must be considered.

Permanent Deafness Associated with Furosemide Administration

Six cases of hearing impairment have been presented. Furosemide was administered to all of these patients at the time of the alleged onset of the deafness. None of the known or suspected causes of deafness occurring in transplant patients was evident in these cases. With the experimental evidence that furosemide does induce stria damage and the absence of other recognized causes of deafness in this series of patients, furosemide must be considered the etiologic agent responsible for the permanent sensorineural hearing loss. A characteristic audiometric pattern of hearing impairment emerged and a possible explanation for these features has been given. Certain precautionary steps in the use of ototoxic drugs are suggested.

Labyrinthine pathology of chronic renal failure patients treated with hemodialysis and kidney transplantation

An audiologic study of 290 hemodialysis and renal transplant patients revealed that in 43 of these patients significant hearing loss developed which could be directly attributed to the therapy of the kidney problem.

The etiology of laryngeal papillomatosis.

Sophisticated virological techniques are described for isolating whole virus, free viral DNA, or integrated viral DNA. Based upon preliminary results, it is suggested that the virus responsible for laryngeal papillomatosis is not the same as the virus responsible for cutaneous papillomatosis lesions and, for the most part, it exists in the integrated DNA form.

Hearing Loss in Patients with Dialysis and Renal Transplants

Hearing loss in renal dialysis and renal transplant patients occurs quite frequently. An assessment of the likely etiological factors is nearly impossible in a retrospective analysis of any one patient because many factors exist simultaneously. In a prospective study of a large series of patients an identification of factors contributing to the hearing loss was possible in the majority of patients. During the study it became increasingly apparent that what was observed at any one time was the combined effect of many factors. Although one factor seemed to precipitate the hearing loss it was inadvisable to attribute total responsibility to that agent or circumstance. Further, this combined effect was not a simple addition of effects but potentiation. The serious implications of this phenomenon are discussed.

Estimate of vitamin A in the guinea pig cochlea.

— Microfluorometric estimates of the membranous structures of the freeze-dried guinea pig cochlea have demonstrated that vitamin A is present in these tissues at a concentration of 21.2 μg/gm (SD ± 4.77 μg) which is approximately ten times the vitamin A concentration in most other tissues.

Temporal bone histopathology in experimental hypovitaminosis A.

Twenty‐five years ago hearing loss was observed in some subjects during a comprehensive study of the effects of hypovitaminosis A on human volunteers. Experimental studies documenting histopathological changes in the temporal bone due to hypovitaminosis A are conflicting. Even the recent textbooks of otolaryngology and physiology make no mention of a role of vitamin A in the ear. To explore the role of vitamin A in the ear adult and. weanling rats maintained on a diet totally lacking vitamin A were sacrificed at intervals. Their temporal bones were examined with the light microscope.