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Dive into the research topics where Célia R. A. Maltha is active.

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Featured researches published by Célia R. A. Maltha.


Molecules | 2008

Evaluation of the chemical composition of Brazilian commercial Cymbopogon citratus (D.C.) stapf samples.

Luiz C. A. Barbosa; Ulisses A. Pereira; Ana Paula Martinazzo; Célia R. A. Maltha; Róbson Ricardo Teixeira; Evandro de Castro Melo

The concentration and the chemical composition of the essential oils obtained from different samples of Cymbopogon citratus were evaluated. Among the 12 samples investigated (11 dried leaf samples and fresh plant leaves), seven presented essential oil concentrations within the threshold established by the Brazilian legislation. The moisture content was also determined and the majority of the samples presented humidity contents near 12%. The GC and GC/MS analyses of the essential oils led to identification of 22 compounds, with neral and geranial as the two major components. The total percentage of these two compounds varied within the investigated sample oils from 40.7% to 75.4%. In addition, a considerable variation in the chemical composition of the analyzed samples was observed. The process of grinding the leaves significantly decreased (by up to 68%) the essential oil content, as well as the percentage of myrcene in the oils.


Molecules | 2011

Seasonal Variation in the Chemical Composition and Antimicrobial Activity of Volatile Oils of Three Species of Leptospermum (Myrtaceae) Grown in Brazil

Antonio J. Demuner; Luiz C. A. Barbosa; Cassia Gonçalves Magalhaes; Cleber J. Silva; Célia R. A. Maltha; Antônio L. Pinheiro

This study investigates the seasonal variation of three species of Leptospermum (Myrtaceae) grown in Brazil. The chemical composition of the volatile oils of L. flavescens and L. petersonii did not show any significant seasonal variation in the major components, while for Leptospermum madidum subsp. sativum the levels of major constituents of the volatile oils varied with the harvest season. Major fluctuations in the composition of L. madidum subsp. sativum oil included α-pinene (0–15.2%), β-pinene (0.3–18.5%), α-humulene (0.8–30%), 1,8-cineole (0.4–7.1%) and E-caryophyllene (0.4–11.9%). Levels of β-pinene (0.3–5.6%), terpinen-4-ol (4.7–7.2%) and nerolidol (55.1–67.6%) fluctuated seasonally in the L. flavescens oil. In L. petersonii, changes were noted for geranial (29.8–32.8%), citronellal (26.5–33.9%) and neral (22.7–23.5%). The activity of the volatile oils against the tested bacteria differed, depending on season the oils were obtained. In general, the volatile oils were more active against Gram-positive bacteria.


Bioorganic & Medicinal Chemistry Letters | 2014

γ-Alkylidene-γ-lactones and isobutylpyrrol-2(5H)-ones analogues to rubrolides as inhibitors of biofilm formation by gram-positive and gram-negative bacteria.

Ulisses A. Pereira; Luiz C. A. Barbosa; Célia R. A. Maltha; Antonio J. Demuner; Mohammed A. Masood; Andréa L. Pimenta

Several molecules have been discovered that interfere with formation of bacterial biofilms, opening a new strategy for the development of more efficient treatments in case of antibiotic resistant bacteria. Amongst the most active compounds are some natural brominated furanones from marine algae Delisea pulchra that have proven to be able to control pathogenic biofilms. We have recently reported that some rubrolide analogues are able to inhibit biofilm formation of Enterococcus faecalis. In the present Letter we describe results of the biological evaluation of a small library of 28 compounds including brominated furanones and the corresponding lactams against biofilm formation of Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis and Streptococcus mutans. Our results showed that in general these compounds were more active against biofilms of S. epidermidis and P. aeruginosa, with little or no inhibition of planktonic bacterial growth. In some cases they were able to prevent biofilm formation of P. aeruginosa at concentrations as low as 0.6 μg/mL (1.3 μM, compound 3d) and 0.7 μg/mL (1.3 μM, 3f). Results also indicate that, in general, lactams are more active against biofilms than their precursors, thus designating this class of molecules as good candidates for the development of a new generation of antimicrobial drugs targeted to biofilm inhibition.


European Journal of Medicinal Chemistry | 2014

Inhibition of Enterococcus faecalis biofilm formation by highly active lactones and lactams analogues of rubrolides

Ulisses A. Pereira; Luiz C. A. Barbosa; Célia R. A. Maltha; Antonio J. Demuner; Mohammed A. Masood; Andréa L. Pimenta

Seven β-aryl substituted γ-alkylidene-γ-lactones analogues of rubrolides were synthesized from mucobromic acid and converted through a lactamization with isobutylamine into their corresponding γ-hydroxy-γ-lactams (76-85%). These lactams were converted into (Z)- and (E)-γ-alkylidene-γ-lactams (23-45%). All compounds were fully characterized by IR, NMR ((1)H and (13)C), COSY and HETCOR bidimensional experiments, and NOE difference spectroscopy experiments when necessary. Evaluation of these three different classes of compounds against Enterococcus faecalis biofilm formation showed that all classes are active and the highest biofilm inhibition activity was caused by lactam 13f (IC50 = 0.76 μg/mL). Moreover, in almost all cases at least one of the lactams is more active than its correspondent γ-alkylidene-γ-lactone. The use of rubrolides as a lead structure has proven successful for the identification of new compounds displaying novel antibacterial activities, namely biofilm inhibition, which have the potential for the development of antimicrobial drugs targeted to inhibition of the initial stages of bacterial infections, rather than bacterial viability. Such drugs are less prompt to induce bacterial resistance, being therefore a more cost-effective investment for pharmaceutical research.


Journal of Agricultural and Food Chemistry | 2012

Synthesis of rubrolide analogues as new inhibitors of the photosynthetic electron transport chain.

L. C. Barbosa; Célia R. A. Maltha; Mateus R. Lage; Rosimeire C. Barcelos; Alice Donà; José Walkimar de M. Carneiro; Giuseppe Forlani

Many natural products have been used as a model for the development of new drugs and agrochemicals. Following this strategy 11 rubrolide analogues, bearing electron-withdrawing and -donating groups at both benzene rings, were prepared starting from commercially available mucobromic acid. The ability of all compounds to inhibit the photosynthetic electron transport chain in the chloroplast was investigated. The rubrolide analogues were effective in interfering with the light-driven ferricyanide reduction by isolated chloroplasts. The IC(50) values of the most active derivatives are in fact only 1 order of magnitude higher than those of commercial herbicides sharing the same mode of action, such as Diuron (0.27 μM). QSAR studies indicate that the most efficient compounds are those having higher ability to accept electrons, either by a reduction process or by an electrophilic reaction mechanism. The results obtained suggest that the rubrolide analogues represent promising candidates for the development of new active principles targeting photosynthesis to be used as herbicides.


Molecules | 2010

Synthesis and Biological Evaluation of 2,5-Bis(alkylamino)-1,4- benzoquinones

Luiz C. A. Barbosa; Ulisses A. Pereira; Célia R. A. Maltha; Róbson Ricardo Teixeira; Vânia Maria Moreira Valente; José R.O. Ferreira; Letícia V. Costa-Lotufo; Manoel Odorico de Moraes; Cláudia Pessoa

A series of twelve 2,5-bis(alkylamino)-1,4-benzoquinones were prepared in yields ranging from 9–58% via the reaction between p-benzoquinone and various amines. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR and MS analyses. The phytotoxicity of the 2,5-bis(alkylamino)-1,4-benzoquinones was evaluated against two crop species, Cucumis sativus and Sorgum bicolor, at 1.0 × 10-3 mol/L. In general, the quinones displayed inhibitory effects on the dicotyledonous species C. sativus (7–74%). On the other hand stimulatory effects were observed on S. bicolor (monocotyledonous). Similar results were observed in the biological assays carried out with the weed species Ipomoea grandifolia (dicotyledonous) and Brachiaria decumbens (monocotyledonous). In addition, the cytotoxicity of the 2,5-bis(alkylamino)-1,4-benzoquinones was assayed against HL-60 (leukemia), MDA-MB-435 (melanoma), SF-295 (brain) and HCT-8 (colon) human cancer cell lines and human peripheral blood mononuclear cells (PBMC), as representatives of healthy cells, using a MTT and an Alamar Blue assay. Compound 12 was the most active, displaying cytotoxicity against all cancer cell lines tested.


European Journal of Medicinal Chemistry | 2010

Synthesis of novel α-santonin derivatives as potential cytotoxic agents.

Francisco F. P. Arantes; Luiz C. A. Barbosa; Célia R. A. Maltha; Antonio J. Demuner; Patrícia Marçal da Costa; José R.O. Ferreira; Letícia V. Costa-Lotufo; Manoel Odorico de Moraes; Cláudia Pessoa

Ten novel α-santonin derivatives have been synthesized as cytotoxic agents. The in vitro antitumor activity of these compounds has been evaluated against cancer cells lines. Structure-activity relationships indicate that α-methylene-γ-lactone and endoperoxide functionalities play important roles in conferring cytotoxicity. The compounds 2-4, possessing the α-methylene-γ-lactone group showed IC50 values between 5.70 and 16.40 μM. Mixture of isomers 5 and 6, with the α-methylene-γ-lactone and endoperoxide functionalities, displayed the greatest activity, with IC50 values between 1.45 and 4.35 μM. The biological assays conducted with normal cells revealed that the compounds 2, 5 and 6 are selective against cancer cells lines tested. Bioactive lactones described herein and in our previous report did not cause disruption of the cell membrane in mouse erythrocytes.


Molecules | 2007

Synthesis and Cytotoxic Activity of Some 3-Benzyl-5-Arylidenefuran-2(5H)-ones

Róbson Ricardo Teixeira; Luiz C. A. Barbosa; Célia R. A. Maltha; Marcelo Rocha; Daniel P. Bezerra; Letícia Costa-Lotuf; Cláudia Pessoa; Manoel Odorico de Moraes

3-Benzyl-furan-2(5H)-one (2a) and 3-(4-bromobenzyl)-furan-2(5H)-one (2b) were treated with TBDMSOTf and converted into the corresponding tert-butyldimethyl-silylfuran ethers. These furans were further condensed with several aromatic aldehydes affording compounds 5-14 with general 3-benzyl-5-arylidene-furan-2(5H)-one structures in 31% to 98% yields. Such compounds are analogues of the naturally occurring nostoclide lactones, reported to present moderate cytotoxic activity. Compounds 5-14 were submitted to an in vitro bioassay against the HL-60, HCT-8, SF295 and MDA-MB-435 cancer cell lines using the MTT cytotoxicity assay.


Journal of Chemometrics | 2011

A quantum chemical and chemometric study of sesquiterpene lactones with cytotoxicity against tumor cells

Francisco F. P. Arantes; L. C. Barbosa; Célia R. A. Maltha; Antonio J. Demuner; Paulo H. Fidêncio; José Walkimar de M. Carneiro

The semi‐empirical molecular orbital method PM6 was employed to calculate a set of molecular descriptors of 20 sesquiterpene lactones (SQLs) with cytotoxicity against HL‐60 (leukemia) tumor cells. The principal component analysis (PCA) and hierarchical cluster analysis (HCA) methods were used to obtain possible relationships between the calculated descriptors and the biological activity of the lactones. Four descriptors were identified as responsible for the separation between the active and inactive compounds: EHOMO (highest occupied molecular orbital energy); Q11 (net atomic charge on C11); Q12 (net atomic charge on C12) and Q13 (net atomic charge on C13). These results indicated that the presence of the α‐methylene‐γ‐lactone group has a significant role in the mechanism by which SQLs exert their biological activities.In order to deepen our knowledge about the structure–activity relationship of sesquiterpene lactones (SQLs), a quantum chemical and chemometric study of sesquiterpene lactones with cytotoxicity was performed against HL‐60 (leukemia) tumor cells. The analysis of the molecular descriptors identified as responsible for the separation between the active and inactive compounds indicated that the presence of the α‐methylene‐γ‐lactone functionality has a significant role in the mechanism by which SQLs exert their biological activities. Copyright


Química Nova | 2003

Síntese e avaliação da atividade fitotóxica de novos análogos oxigenados do ácido helmintospórico

Luiz C. A. Barbosa; Antonio J. Demuner; Célia R. A. Maltha; Patricia Silva; Antonio Alberto da Silva

Several compounds related to helminthosporic acid (3) were synthesized via the [3+4] cycloaddition. The reaction of 3-hydroxymethyl-2-methylfuran (12) with 1,1,3,3-tetrabromo-4-methylpentan-2-one (13) resulted in 7-hydroxymethyl-4a-isopropyl-1a-methyl-8-oxabicyclo[3.2.1]oct-6-en-3-one (8) (37%) and 7-hydroxymethyl-2a-isopropyl-1a-methyl-8-oxabicyclo[3.2.1]oct-6-en-3-one (14) (12%), which were converted into 7-formyl-4a-isopropyl-1a-methyl-8-oxabicyclo[3.2.1]oct-6-en-3-one (16) (32% from 8) and 7-formyl-2a-isopropyl-1a-methyl-8-oxabicyclo[3.2.1]oct-6-en-3-one (18) (40% from 14), respectively. Reduction of (8) resulted in 7-hydroxymethyl-4a-isopropyl-1a-methyl-8-oxabicyclo[3.2.1]oct-6 -en-3a-ol (11) (63% from 8) and 7-hydroxymethyl-4a-isopropyl-1a-methyl-8-oxabicyclo[3.2.1]oct-6-en-3 b-ol (15) (30% from 8). The 4a-isopropyl-1a-methyl-3-oxo-8-oxabicyclo[3.2.1]oct-6-en-7-oic acid (19) was obtained by oxidation of (16) (78%). The results of biological tests are described in details. The best result was observed for compound (15) that caused 76% inhibition on the root growth of D. tortuosum.

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Luiz C. A. Barbosa

Universidade Federal de Minas Gerais

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Antonio J. Demuner

Universidade Federal de Viçosa

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L. C. Barbosa

State University of Campinas

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Róbson Ricardo Teixeira

Universidade Federal de Viçosa

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Dorila Piló-Veloso

Universidade Federal de Minas Gerais

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Ulisses A. Pereira

Universidade Federal de Minas Gerais

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Antonio Alberto da Silva

Universidade Federal de Viçosa

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Mariluze P. Cruz

Universidade Federal de Viçosa

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Sergio Antonio Fernandes

Universidade Federal de Viçosa

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