Cemal Tasdemir

Protective Effect of Infliximab on Ischemia/Reperfusion-Induced Damage in Rat Kidney

Objective: To investigate the protective effect of infliximab on ischemia–reperfusion (I/R) injury of the rat kidney. Methods: Twenty-eight male Wistar albino rats were divided into four groups: sham-operated, I/R, I/R with infliximab administered before ischemia [I/R + infliximab (bi)], and I/R with infliximab administered before reperfusion [I/R + infliximab (br)]. After a right nephrectomy to produce damage, the left renal vessels were occluded for 60 min, followed by 24-h reperfusion in rats. Changes in the rat kidney were observed by measuring the tissue levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), and superoxide dismutase (SOD) and by evaluating hematoxylin–eosin (H&E)-stained and periodic acid–Schiff (PAS) sections. Results: The MDA and MPO levels in the I/R group were significantly higher than in the other groups (p < 0.05), and the SOD and GSH levels in the I/R + infliximab (bi) and I/R + infliximab (br) groups were significantly higher than in the I/R group (p < 0.05). However, histological examination revealed that the I/R + infliximab (bi) group and the I/R + infliximab (br) group had significantly fewer tubular changes and interstitial inflammatory cell infiltration than the I/R group. Conclusion: These results show that infliximab may protect against I/R injury in the rat I/R model.

Intravesical hyaluronic acid and chondroitin sulfate alone and in combination for urinary tract infection: Assessment of protective effects in a rat model

Objective:  To determine the protective effects of hyaluronic acid and chondroitin sulfate in treating urinary tract infections in a rat model.

Erectile dysfunction in testicular cancer patients treated with chemotherapy

Information on male potency in testicular cancer (TC) patients treated with chemotherapy is insufficient. We aimed to assess the levels of depression and anxiety symptoms, sexual function and gonodotrophins. Participants (n = 27) were identified and recruited from the genitourinary services of two medical centres, one in Inonu University and the other in the Firat University. All patients are TC patients treated with chemotherapy after unilateral orchiectomy. Participants completed follow‐up assessments after the completion of the chemotherapy regimen. Serum luteinising hormone, follicle‐stimulating hormone and testosterone levels were determined after blood samples had been taken in the morning after an overnight fast. International Index of Erectile Function (IIEF‐15) was also used to evaluate erectile dysfunction (ED) score. Beck Depression and Beck Anxiety Scale were used to assess psychological symptoms. The findings indicated that men treated with chemotherapy had significantly different IIEF‐15 and Beck Anxiety scores compared with men who did not receive chemotherapy. But no statistically significant difference was determined in the serum gonodotrophin levels and depression score between the two groups. It is concluded that patients with TC undergoing chemotherapy have greater risk than normal men for ED, independently of the gonodotrophins level.

Are neutrophil-lymphocyte and platelet-lymphocyte ratios valuable in predicting prostate cancer? -

Introduction and Hypothesis: We retrospectively evaluated the prognostic impact of neutrophil-lymphocyte ratio (NLR) as a marker for inflammatory and immune state in men with prostate cancer. Materials and Methods: This retrospective study was conducted in a single urology clinic to review the medical data of 558 patients who underwent transrectal prostate needle biopsies between 2007 and 2014. Prior to transrectal prostate needle biopsies, patient histories, physical examinations, and routine laboratory tests including blood biochemistry, urinaly- sis and urine cultures, free PSA and total PSA, rectal examination, transrectal ultrasound findings, and pathology results were evaluated. Results: Benign biopsy results were found in 287 patients (Group 1) using neutrophil / lymphocyte (NLR) and platelet / lymphocyte ratio (PLR). When calculating malignancy in 271 patients (Group 2), there was no significantly difference in NLR and PLR values between benign and malign prostate diseases (p=0.14 and p=0.369, respectively). Conclusion: With reference to the survey prior to the biopsy, NLR and PLR ratio values do not appear to be helpful in the differentiation of benign prostatic hyperplasia and prostate cancer.

Percutaneous nephrolithotomy in very elderly patients (Age 75 and Over)

Amac: Perkutan nefrolitotomi (PNL),tum dunyada bobrek tasi cerrahi tedavisinde guvenle kullanilan minimal invaziv bir yontemdir. Ilk PNL ameliyati Mart 1998 tarihinde yapilan klinigimizde yetmis bes yas uzeri ilk PNL ameliyati ise Haziran 2000 tarihinde bilateral olarak yapildi. Calismamizda, 75 yas ve ustu hastalara yapilan PNL operasyonlari incelendi. Yontemler: PNL islemleri genel anestezi altinda yapildi. Hastalara, supin pozisyonda sistoskopi yapildiktan sonra ureter orifisinden ureter kateteri C kollu floroskopi esliginde takilarak uretral foley katetere tespit edildi. Sonrasinda hastalar prone pozisyona alinarak floroskopi esliginde Chiba ignesi ile bobrege girildi. Amplatz renal dilatator setiyle 30F’e kadar dilatasyon saglandi. Islem sonrasi renal kilif icerisinden nefrostomi kateteri yerlestirildi. PNL sonrasi 4 mm’den kucuk taslar, klinik onemsiz tas reziduleri kabul edildi. Bulgular: Mart 1998 – Aralik 2014 tarihleri arasinda, 16 yilda toplam 3003 perkutan nefrolitotomi islemi yapildi. Bu hastalardan 27 tanesi 75 yas ve uzeriydi. Bu hastalara, biri bilateral olmak uzere 28 PNL islemi yapildi. Hastalarin yas ortalamasi 79,37 (75-88) yil olarak hesaplandi. 20 (%74) hastada tam tassizlik saglandi. 2 hastada tubeless PNL yapildi. Viseral organ yaralanmasi, sepsis ya da olum gorulmedi. Sonuc: Minimal invaziv bir yontem olan PNL, yuksek guvenlik, dusuk komplikasyon oranlari, daha kisa hastanede kalis suresi, yuksek hasta memnuniyeti saglamasi, daha yuksek tassizlik oranlari ile acik bobrek tasi cerrahisine gore avantajli bir hale gelmistir. Uriner sistem tas hastaliginin cerrahi tedavisinde PNL guvenli ve etkili bir yontemdir